The Correlation Between Hepatitis B Virus Precore/Core Mutations and the Progression of Severe Liver Disease.
PMID: 30406036
2018
Frontiers in cellular and infection microbiology
Introduction: Similarly, the role of the precore mutation G1896A and the basal core promoter double mutation A1762T/G1764A in the progression of HBV-related liver diseases has been intensively studied (Kim et al.,).
[Risk factors analysis and a new risk scoring system predicting hepatocarcinogenesis for chronic genotype C HBV infected patients].
PMID: 30462954
2018
Zhonghua liu xing bing xue za zhi
Abstract: In genotype C HBV infected patients, male gender, aged 40 years and over, and four DNA mutations (T1674CG, A1762T/G1764A, A3120T, and A2962G) can increase the risk of HCC (P<0.05); interferon therapy can reduce the risk of HCC (P<0.05).
The Effect of ICOS Polymorphism Interactions with HBV Mutations on HBV Subtype Infection Outcomes.
1Abstract: Further study indicated that interactions between ICOS rs10932029 genotype ""TC"" and A1762T or A1762T/G1764A mutations significantly decreased the LC risk in the genotype C group."
1Abstract: The interactions between the rs10932029 genotype ""TC"" and A1762T or A1762T/G1764A mutations could decrease the risk of LC."
Abstract: Additionally, the A1762T, G1764A and A1762T/G1764A mutations were associated with an increased risk of LC in the genotype C group.
Applications of next-generation sequencing analysis for the detection of hepatocellular carcinoma-associated hepatitis B virus mutations.
Abstract: All the 12 HCC-associated SNVs proved by meta-analysis were confirmed by NGS analysis, except for C1766T and T1768A which were mainly expressed in genotypes A and D, but including the subgroup analysis of A1762T.
The association between hepatitis B mutants and hepatocellular carcinoma: A meta-analysis.
Abstract: A meta-analysis of pooled results from case-control studies examined the association between mutations G1896A, A1762T, G1764A, and A1762T/G1764A and the risk of HCC.
Abstract: CONCLUSION: In summary, we found that G1896A, A1762T, G1764A, and A1762T/G1764A are associated with an increased risk of HCC.
Abstract: RESULTS: We included 29 articles for analysis and found that G1896A (summary odds ratios [OR] = 2.04, 95% confidence interval [CI] = 1.41-2.95), PMID: 27328656
2017
Journal of medical virology
Abstract: Difference in basal core promoter A1762T/G1764A mutations and precore G1896A mutation incidences was not significant between B/C recombinant and genotypes B or C virus, although the significance was there between genotypes B and C viruses.
Hepatitis B virus infection in children of HBV-related chronic liver disease patients: a study of intra-familial HBV transmission.
Abstract: Recognized mutations associated with HBsAg detection and/or vaccination failure, T140I, T143S/M, G145R, and Y161F, were identified in 20 subjects; while mutations linked to HBeAg-defective variants, PC G1896A and BCP A1762T/G1764A, were found in 7 and 11 subjects, respectively.
Effects of amino acid substitutions in hepatitis B virus surface protein on virion secretion, antigenicity, HBsAg and viral DNA.
Abstract: The precore/core mutations A1762T + G1764A (40.9%) were found mostly in genotypes A and D, and G1896A (29.55%) was more frequent in genotype D than in genotype A.
A novel hepatitis B virus subgenotype D10 circulating in Ethiopia.
HBV mutation literature information.
PMID: 
2018
Frontiers in cellular and infection microbiology
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