Conclusion: Also the basal core promoter region of HBV genome was not sequenced in this study, therefore, the prevalence of A1762T and G1764A mutations could not be determined.
Discussion: Most published data state that HBeAg-negative chronic hepatitis B due to preC mutations is common in non-A genotypes only, and that mutations that often lead to reduced production of HBeAg in genotype A are confined to the core promoter region (A1762T and G1764A).
Hepatitis B virus in the State of Alagoas, Brazil: genotypes characterization and mutations of the precore and basal core promoter regions.
PMID: 24021712
2013
The Brazilian journal of infectious diseases
Abstract: The aims of this study were to investigate the genotypes of hepatitis B virus and to identify the precore G1896A and basal core promoter A1762T/G1764A mutations in HBsAg and anti-HBc-positive patients.
High endemicity and low molecular diversity of hepatitis B virus infections in pregnant women in a rural district of North Cameroon.
Abstract: In the BCP region, the double mutation A1762T/G1764A and the G1757A substitution were detected respectively in 26/228 patients (11.4%) and 189/228 patients (82.8%).
Method: In the BCP region, the two-nucleotide substitutions, A-T at nucleotide 1762 and G-A at nucleotide 1764 (A1762T/G1764A), signal the double mutant BCP phenotype.
Table: A1762T
Association of Hepatitis B Virus Mutations of A1846T and C1913A/G With Acute-on-Chronic Liver Failure Development From Different Underlying Chronic Liver Diseases.
Abstract: In addition, there were no significant differences in mutations at
Introduction: In addition, the mutation in the basic core promoter (BCP), such as double mutation A1762T/G1764A, has been found to enhance HBV replication in vitro.
Introduction: In comparison with CHB patients, liver cirrhosis (LC) patients have more frequent mutations in BCP/PC region such as A1762T/G1764A, T1753V, and/or G1896A.
Table: A1762T
Hepatitis B virus subgenotype A1 predominates in liver disease patients from Kerala, India.
PMID: 24409056
2013
World journal of gastroenterology
Abstract: Mutation G1862T was more frequent in subgenotype A1 (P < 0.0001), and in combination with A1762T/G1764A, it was significantly associated with HBV from HCC patients.
Abstract: Mutation A1762T/G1764A was significantly associated with HCC in both genotypes A and D.
HBsAg, HBeAg and HBV DNA level changes and precore/basal core promoter mutations in the natural history of chronic hepatitis B in Indonesian patients.
Abstract: We studied the changes in hepatitis B surface antigen (HBsAg), hepatitis B 'e' antigen (HBeAg) and HBV DNA levels, considering the implications of HBV genotype, basal core promoter (BCP) A1762T/G1764A and precore G1896A mutations in CHB.
Combination of preS deletions and A1762T/G1764A mutations in HBV subgenotype C2 increases the risk of developing HCC.
Abstract: Additionally, the frequency of A1762T/G1764A mutations was higher in the HCC than the non-HCC group [82 (60.7%) versus 30 (22.2%), p < 0.001].
Abstract: CONCLUSIONS: HCC was associated with preS deletions and A1762T/G1764A mutations, and the combination of both mutations had a stronger association with HCC in Korean patients infected with HBV subgenotype C2.
Abstract: For combined mutations, the odds ratio (OR) was highest in patients with both preS deletions and the A1762T/
Precore/core promoter mutations and hepatitis B virus genotype in hepatitis B and C dually infected patients treated with interferon-based therapy.
Abstract: Among dually-infected patients, genotype C was associated with a higher frequency of A1762T/G1764A mutation (P<0.001), but with lower HBV DNA (P<0.001) and a lower frequency of A1752T/G (P=0.008), C1799G (P<0.001) and G1896A mutation (P<0.001) than genotype B.
Mutational complex genotype of the hepatitis B virus X /precore regions as a novel predictive marker for hepatocellular carcinoma.
Abstract: CONCLUSIONS: Levels of G1896A and A1762T/G1764A mutants (of genotypes B and C) in the HBeAg-positive patients may predict the time of HBeAg seroconversion.
Abstract: Follow-up of 18 HBeAg-positive patients revealed that the mutant percentage may stay low and stable for many years, followed by a steady increase in the percentage of G1896A and/or A1762T/G1764A mutants, from <10% to 50-100%, within about 3 years prior to seroconversion.
Abstract: Mutant viruses carrying the precore G1896A and/or the basal core promoter (
HBV mutation literature information.
PMID: 
2013
Journal of medical virology
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