literature

HBV mutation literature information.

Effect of functional nuclear factor-kappaB genetic polymorphisms on hepatitis B virus persistence and their interactions with viral mutations on the risk of hepatocellular carcinoma.

PMID: 25223483 2014 Annals of oncology

Abstract: In the genotype C HBV-infected subjects, rs2233406 variant genotypes were significantly associated with an increased risk of HCC [CT versus CC: age-, gender-adjusted odds ratio (AOR), 1.33; 95% confidence interval (CI) 1.01-1.75 in training set and AOR, 1.59; 95% CI 1.01-2.52 in validation set] compared with HCC-free HBV-infected subjects and significantly increased the frequencies of HCC-related HBV mutations (A1762T/G1764A, T1753V, preS1 start codon mutation, and preS deletion); rs28362491 (Del/Del or Ins/Del + Del/Del versus Ins/Ins) signific

Hepatitis B virus depicts a high degree of conservation during the immune-tolerant phase in familiarly transmitted chronic hepatitis B infection: deep-sequencing and phylogenetic analysis.

PMID: 25244642 2014 Journal of viral hepatitis

Abstract: By deep-sequencing, the quantitative analysis of the dynamics of basal core promoter (BCP) (A1762T, G1764A; A1766C; T1773C; 8-bp deletion; and other) and precore (G1896A) variants among HBV isolates from family members exhibited differences during the follow-up.

Significance of mutations in hepatitis B virus X gene for the pathogenesis of HB-associated glomerulonephritis.

PMID: 25283864 2014 Acta virologica

Abstract: In HBV-GN patients, missense nucleotide mutations of C1653T, A1726C, A1727T, C1730G, T1753C, A1762T, and G1764A were detected in 84% of subjects, all located in the trans-acting regulatory region of the X gene.

Prevalence of mutations in basal core promoter and precore region of hepatitis B virus in vaccinated and nonvaccinated individuals of the aboriginal Nicobarese tribe of Car Nicobar Island, India.

PMID: 25323975 2014 Intervirology

Abstract: Among the nonvaccinated subjects, 3 (4.5%) had an A1762T mutation, 8 (12.1%) had a G1764A mutation, 11 (16.7%) had a G1896A mutation and 4 (6.1%) had a G1899A mutation.

Novel point and combo-mutations in the genome of hepatitis B virus-genotype D: characterization and impact on liver disease progression to hepatocellular carcinoma.

PMID: 25333524 2014 PloS one

Abstract: Beyond the classical mutations in basal core promoter (BCP) (A1762T/G1764A) and precore (G1862T), persistence of progressively accumulated mutations in enhancer-I, surface, HBx and core were showed significant association to liver disease progression.

Abstract: Furthermore, the effect of individual mutation was magnified by the combination with A1762T/G1764A in HCC pathogenesis.

Table: A1762T

Hepatitis B virus core promoter mutations in patients with chronic hepatitis B and hepatocellular carcinoma in bucharest, romania.

PMID: 25477976 2014 Hepatitis monthly

Result: BCP A1762T, G1764A and PC G1896A were significantly associated with HCC-tissue HBV sequencing (75.3%).

Result: D genotype was mainly associated with presence of PC G1896A (50.1% from D-patients present PC G1896A or BCP A1762T, G1764A-PC G1896); .

Result: D genotype was mainly associated with presence of PC G1896A (50.1% from D-patients present PC G1896A or BCP A1762T, G1764A-PC G1896).

Genetic characterization and genotyping of hepatitis B virus (HBV) isolates from donors with an occult HBV infection.

PMID: 25040474 2014 Vox sanguinis

Abstract: Mutations in the S region (100%) were found especially in loop 1 of the major hydrophilic loop (MHL) at positions I110L, T114S, T126I and S113T, whereas mutations in the C region (65%) were within the basal core promoter region (position A1762T/G1764A) and precore region (position G1896A).

[Correlation study on Chinese medical syndrome types of chronic hepatitis B patients and HLA-DR13 gene, BCP mutation, and T-lymphocyte subsets].

PMID: 25566621 2014 Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi

Abstract: The mutation of serum A1762T/G1764A was detected using PCR sequencing.

[Relationship between hepatitis B virus polymerase gene mutation patterns of rtM204I/V and pre-core/basal core promoter mutations].

PMID: 25654280 2014 Zhonghua gan zang bing za zhi

Abstract: OBJECTIVE: To investigate the relationship between mutations of rtM204V/I (methionine to valine or isoleucine at position rt204 of reverse transcriptase domain) in the hepatitis B virus (HBV) polymerase gene and the G1896A and G1899A single mutations in the pre-eore (PC) region and the A1762T and G1764A double-mutations in the basal core promoter (BCP) region.

Abstract: Of the 1543 strains (54.2%) with PC-BCP mutations, seven mutation patterns of

S gene mutants occurrence among hepatitis B carriers in malaysia.

PMID: 25737728 2014 Hepatitis monthly

Result: Among the basal core promoter mutations, A1762T-G1764A double mutation was present in 26.9%, C1653T in 8.6%, A1752G in 10.8% and C1766T in 2.2% of the isolates.

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