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 HBV mutation literature information.


  Mutations of Basal core promoter and precore regions in hepatitis B virus genotypes B and C.
 PMID: 25741368       2015       Hepatitis monthly
Table: A1762T


  Clinical utility of complex mutations in the core promoter and proximal precore regions of the hepatitis B virus genome.
 PMID: 25625002       2015       World journal of hepatology
Abstract: We previously demonstrated that the accumulation of >= 6 mutations at eight key nucleotides located in these regions (G1613A, C1653T, T1753V, A1762T, G1764A, A1846T, G1896A, and G1899A) is a useful marker to predict the development of HCC regardless of advanced liver disease.


  Mutations of pre-core and basal core promoter before and after hepatitis B e antigen seroconversion.
 PMID: 25593470       2015       World journal of gastroenterology
Abstract: METHODS: The proportion of pre-core (G1896A) and basal core promoter (A1762T and G1764A) mutant viruses and serum levels of hepatitis B virus (HBV) DNA, hepatitis B surface antigen (HBsAg), and HB core-related antigen were analyzed in chronic hepatitis B patients before and after HBeAg seroconversion (n = 25), in those who were persistently HBeAg positive (n = 18), and in those who were persistently anti-HBe positive (n = 43).


  Hepatitis B Virus Core Promoter A1762T/G1764A (TA)/T1753A/T1768A Mutations Contribute to Hepatocarcinogenesis by Deregulating Skp2 and P53.
 PMID: 25567052       2015       Digestive diseases and sciences
Abstract: METHODS: A HBx combination (combo) mutant with changes in the CP region that corresponded to A1762T/G1764A (TA), T1753A, and T1768A was constructed and expressed in L-02 and Hep3B cells.


  Clinical significance of hepatitis B virus precore and core promoter variants in Korean patients with chronic hepatitis B.
 PMID: 24406435       2015       Journal of clinical gastroenterology
Abstract: METHODS: We assessed serum HBeAg, HBV DNA levels, alanine transferase (ALT) levels, and progression of liver fibrosis in 226 Korean CHB patients, presumed to be infected with genotype C HBV, to analyze HBV variants in the preC region (G1896A) and CP regions (A1762T, G1764A).


  Higher proportion of viral basal core promoter mutant increases the risk of liver cirrhosis in hepatitis B carriers.
 PMID: 24763132       2015       Gut
Abstract: BACKGROUND AND OBJECTIVE: Precore (PC) variant (G1896A) and basal core promoter (BCP) variant (A1762T/G1764A) of HBV are associated with risk of hepatocellular carcinoma in HBV carriers.


  Occult hepatitis B virus infection with positive hepatitis B e antigen.
 PMID: 25218700       2015       Clinica chimica acta; international journal of clinical chemistry
Abstract: The HBV had double mutations (A1762T and G1764A) in the basal core promoter but had no mutation in the pre C/C gene in both patients.


  Correlation between the promoter basal core and precore mutations and HBsAg quantification in French blood donors infected with hepatitis B virus.
 PMID: 25170961       2015       Journal of medical virology
Abstract: Direct sequencing of precore/core gene was used to detect A1762T/G1764A mutations in the BCP and G1896A in the PC region.


  Spontaneous HBsAg loss in Korean patients: relevance of viral genotypes, S gene mutations, and covalently closed circular DNA copy numbers.
 PMID: 25320728       2014       Clinical and molecular hepatology
Result: The A1762T and G1764A core promoter mutations were found only in the lamivudine-treated patient.


  Variability in the precore and core promoter region of the hepatitis B virus genome.
 PMID: 24249691       2014       Journal of medical virology
Abstract: The study confirmed that core promoter and precore mutations occur at key positions (A1762T, G1764A, G1896A, and G1899A), and that the proportions of strains with seroconvertion in patients differ between the four HBV genotypes.



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