Abstract: OBJECTIVES: The aim of this study was to identify serum proteins with differential concentrations between hepatocellular carcinoma (HCC) patients and HBsAg asymptomatic carriers among individuals infected with hepatitis B virus (HBV) with basal core promoter (BCP) double mutations (A1762T, G1764A).
Hepatocarcinogenesis in transgenic mice carrying hepatitis B virus pre-S/S gene with the sW172* mutation.
Introduction: For example, high serum or intrahepatic HBV-DNA levels and the presence of basal core promoter A1762T/G1764A mutation can independently predict outcomes of long-term chronic HBV infection as well as postoperative survival in HCC.
Associations between hepatitis B virus basal core promoter/pre-core region mutations and the risk of acute-on-chronic liver failure: a meta-analysis.
Abstract: CONCLUSIONS: The HBV basal core promoter/pre-core mutations T1753V, A1762T, G1764A, C1766T, T1768A, A1846T, G1896A and G1899A, and an HBeAg-negative status correlate with an increased risk of HBV-ACLF.
Abstract: Several mutations were significantly correlated with ACLF: T1753V (1.889, 95 % confidence interval (CI) [1.357-2.631]), A1762T (2.696 [2.265-3.207]), PMID: 25170961
2015
Journal of medical virology
Abstract: Direct sequencing of precore/core gene was used to detect A1762T/G1764A mutations in the BCP and G1896A in the PC region.
Occult hepatitis B virus infection with positive hepatitis B e antigen.
PMID: 25218700
2015
Clinica chimica acta; international journal of clinical chemistry
Abstract: The HBV had double mutations (A1762T and G1764A) in the basal core promoter but had no mutation in the pre C/C gene in both patients.
Higher proportion of viral basal core promoter mutant increases the risk of liver cirrhosis in hepatitis B carriers.
Abstract: BACKGROUND AND OBJECTIVE: Precore (PC) variant (G1896A) and basal core promoter (BCP) variant (A1762T/G1764A) of HBV are associated with risk of hepatocellular carcinoma in HBV carriers.
Clinical significance of hepatitis B virus precore and core promoter variants in Korean patients with chronic hepatitis B.
PMID: 24406435
2015
Journal of clinical gastroenterology
Abstract: METHODS: We assessed serum HBeAg, HBV DNA levels, alanine transferase (ALT) levels, and progression of liver fibrosis in 226 Korean CHB patients, presumed to be infected with genotype C HBV, to analyze HBV variants in the preC region (G1896A) and CP regions (A1762T, G1764A).
Hepatitis B Virus Core Promoter A1762T/G1764A (TA)/T1753A/T1768A Mutations Contribute to Hepatocarcinogenesis by Deregulating Skp2 and P53.
PMID: 25567052
2015
Digestive diseases and sciences
Abstract: METHODS: A HBx combination (combo) mutant with changes in the CP region that corresponded to A1762T/G1764A (TA), T1753A, and T1768A was constructed and expressed in L-02 and Hep3B cells.
Mutations of pre-core and basal core promoter before and after hepatitis B e antigen seroconversion.
PMID: 25593470
2015
World journal of gastroenterology
Abstract: METHODS: The proportion of pre-core (G1896A) and basal core promoter (A1762T and G1764A) mutant viruses and serum levels of hepatitis B virus (HBV) DNA, hepatitis B surface antigen (HBsAg), and HB core-related antigen were analyzed in chronic hepatitis B patients before and after HBeAg seroconversion (n = 25), in those who were persistently HBeAg positive (n = 18), and in those who were persistently anti-HBe positive (n = 43).
HBV mutation literature information.
PMID: 
2016
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