literature

HBV mutation literature information.

Clinical utility of complex mutations in the core promoter and proximal precore regions of the hepatitis B virus genome.

PMID: 25625002 2015 World journal of hepatology

Abstract: We previously demonstrated that the accumulation of >= 6 mutations at eight key nucleotides located in these regions (G1613A, C1653T, T1753V, A1762T, G1764A, A1846T, G1896A, and G1899A) is a useful marker to predict the development of HCC regardless of advanced liver disease.

Mutations of Basal core promoter and precore regions in hepatitis B virus genotypes B and C.

PMID: 25741368 2015 Hepatitis monthly

Table: A1762T

Association of Mutations in the Basal Core Promoter and Pre-core Regions of the Hepatitis B Viral Genome and Longitudinal Changes in HBV Level in HBeAg Negative Individuals: Results From a Cohort Study in Northern Iran.

PMID: 25788956 2015 Hepatitis monthly

Discussion: In contrast to these findings, cross-sectional studies of HBV viral level and liver disease severity have generally suggested associations with A1762T/G1764A double mutation, although these studies were mostly conducted among participants with other HBV genotypes.

Discussion: Some studies indicated that the A1762T/G1764A mutation typically appears earlier than G1896A during the course of HBV infection.

Lower mutation frequency of BCP/precore regions in e antigen-negative chronic HBV-infected children instead of adults patients.

PMID: 25822176 2015 PloS one

Discussion: An A1762T/G1764A double mutation in the BCP/precore region would reduce the levels of HBeAg by inhibiting precore mRNA expression, leading to the transition from the immune tolerance to the immune reactive phase, followed by lower DNA viral loads and elevated ALT levels.

Discussion: Deletions in core regions instead of the G1896A and A1762T/G1764A double mutation were observed in early seroconversion processes in a longitudinal study of infants (our own unpublished data), which also supports the idea that HBeAg seroconversion does not solely rely on BCP

Hepatitis B virus genotype distribution and genotype-specific BCP/preCore substitutions in acute and chronic infections in Argentina.

PMID: 25822666 2015 PloS one

Result: In brief, those patients infected with sgF4 and gD mutated G1896A more frequently than A1762T/G1764A (p = 0.007 and p<0.001 respectively), whereas those patients carrying sgF1b and sgA2 had the opposite mutation pattern, showing higher rates of mutations in positions 1762 and 1764 than in 1896 (p = 0.013 and p = 0.010 respectively).

Result: In spite of the low prevalence of mutations in AHB infections (25.7%), those subgenotypes more frequently observed in this stage, sgA2 and sgF1b, had the double mutation A1762T/G1764A, while gD and sgF4 did not mutate these positions (Table 3).

Result: The double mutation A1762T/G1764A was more frequently found in sgF1b infections (75.

Phosphatase and tensin homologue genetic polymorphisms and their interactions with viral mutations on the risk of hepatocellular carcinoma.

PMID: 25881591 2015 Chinese medical journal

Introduction: We and others have reported that HBV mutations C1653T, T1753V, A1762T/G1764A, T1674C/G, and C1766T/T1768A in the enhancer II/basal core promoter (EnhII/BCP) region; G1899A, C2002T, A2159G, A2189C, and G2203A/T in the precore/core region; as well as T53C,

PMID: 25926495 2015 Journal of clinical microbiology

Abstract: A triple mutation (A1762T/G1764A/G1896A) was observed more frequently in genotype C than in genotype B.

Biological characteristics of the A1762T/G1764A mutant strain of hepatitis B virus in vivo.

PMID: 26165271 2015 Molecular medicine reports

Abstract: The double nucleotide, A1762T and G1764A exchange (TA mutation), in the hepatitis B virus (HBV) genome basal core promoter (BCP) region is a common viral mutation in patients with chronic HBV infection.

Deep sequencing of hepatitis B virus basal core promoter and precore mutants in HBeAg-positive chronic hepatitis B patients.

PMID: 26647737 2015 Scientific reports

Abstract: G1719T, T1753V, A1762T and G1764A were genotype C related.

Abstract: BCP A1762T/G1764A double mutants were generally accompanied with PC 1896 wild type or lower PC G1896A mutant percentage.

Abstract: Lower serum HBeAg and HBsAg levels were associated with higher BCP A1762T/G1764A mutant percentages (>= 50%).

G1896A Precore Mutation and Association With HBeAg Status, Genotype and Clinical Status in Patients With Chronic Hepatitis B.

PMID: 26587040 2015 Hepatitis monthly

Abstract: The basal core promoter mutations detected were A1762T-G1764A (26.9%), C1653T (8.6%), A1752G (10.8%) and C1766T (2.2%).

Result: Among the basal core promoter mutations, A1762T-G1764A double mutation was present in 26.9%, C1653T in 8.6%, A1752G in1 0.8% and C1766T in 2.2% of all isolates.

Table: A1762T

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