The nucleotide changes within HBV core promoter/precore during the first 12weeks of nucleos(t)ide treatment might be associated with a better virological response.
PMID: 28088502
2017
Infection, genetics and evolution
Abstract: The mutation rates of A1762T/G1764A and G1896A were found to decrease from 46.2% (24/52) at baseline to 36.5% (19/52) at week 12 (P=0.426) and from 28.8% (15/52) to 21.2% (11/52) (P=0.497), respectively.
Clinical features and viral quasispecies characteristics associated with infection by the hepatitis B virus G145R immune escape mutant.
Result: With regard to the 'hot-spot' mutations in the HBV genome, G1896A in the preC region and A1762T/G1764A in the basic core promoter region were studied.
Sequence analysis and functional characterization of full-length hepatitis B virus genomes from Korean cirrhotic patients with or without liver cancer.
Result: All the high replicating clones harbored A1762T/ G1764A mutations, and all but the three non-HCC clones harbored G1896A precore mutation.
Result: Consistent with the high prevalence of core promoter mutations in genotype C, especially at the advanced stages of liver diseases, 34 of the 36 clones (including all the 20 HCC-derived clones) harbored the A1762T/G1764A double mutation.
Result: Finally, the only two clones lacking A1762T/G1764A mutations (12.1 and 12.3 from a non-
Hepatitis B virus sequencing and liver fibrosis evaluation in HIV/HBV co-infected Nigerians.
PMID: 28376292
2017
Tropical medicine & international health
5Result: Fifteen (43%) had the double A1762T/G1764A mutation (""TA mutation"") in the BCP region; an additional patient had only G1764A."
8Discussion: The double A1762T/G1764A (""TA"" mutation) in the BCP region affects mRNA transcription and decreases HBeAg production.
Abstract: We identified BCP A1762T/G1764A in 15/35 (43%), PC G1896A in 20/35 (57%), 'a' determinant mutations in 12/45 (26.7%) and preS2 deletions in 6/16 (37.5%).
Complete genome sequencing and clinical analysis of intrahepatic hepatitis B virus cccDNA from HCC.
Abstract: RESULTS: High frequencies of C1653T, T1753V, and A1762T/G1764A cccDNA mutations were observed in both tumor and non-tumor tissues.
A comparative study of hepatitis B virus X protein mutants K130M, V131I and KV130/131MI to investigate their roles in fibrosis, cirrhosis and hepatocellular carcinoma.
Abstract: Furthermore, these might be the possible reasons for higher occurrence of AG1762/1764TA as compared to A1762T and G1764A in cirrhosis and HCC patients.
Abstract: Hepatitis B virus (HBV) genomic mutations A1762T, G1764A and AG1762/1764TA cause production of HBV X protein (HBx) mutants, namely K130M, V131I and KV130/131MI.
Analyses of the Genetic Diversities and Mutations of the Hepatitis B Virus Genome BCP/Pre C Region.
Abstract: Other mutations in descending order by mutation rate were a: A1762T/G1764A combined mutation (90. 48%); G1756C/T1803A/A(1757 ~ 1765)/A (1824 ~ 1832) combined mutation (80. 95%); T1753C/A1762T/ G1764A combined mutation (57. 14%); A1762T/G1764A/G1896A combined mutation (42. 86%); G1756C/_(1757~176.5) combined mutation,(28. 57%); T1753C/A1762T/G1764A/G1896A combined mutation (23. 81%).
Patients with Coexistence of Circulating Hepatitis B Surface Antigen and Its Antibody May Have a Strong Predisposition to Virus Reactivation During Immunosuppressive Therapy: A Hypothesis.
Abstract: DNA sequencing analysis of the HBV genome revealed triple mutations (A1762T, G1764A, and T1753V) in the BCP region, which could further enhance the ability of HBV replication.
Abstract: Recent studies have shown that the uncommon serological pattern of coexistent circulating HBV surface antigen (HBsAg) and its antibody (anti-HBs) was associated with double mutations (A1762T/G1764A) in the basal core promoter (BCP) region of the HBV genome, which is critical for HBV replication.
Introduction: Coexistence of circulating HBsAg and anti-
Associations between serum HBX quasispecies and their integration in hepatocellular carcinoma.
PMID: 31966550
2017
International journal of clinical and experimental pathology
Abstract: In these, the HBX-integrated groups had significantly higher mutation frequencies at C1497T, A1630G, G1721A, A1762T/G1764A and A1774G.
Chronic hepatitis B carriers with acute on chronic liver failure show increased HBV surface gene mutations, including immune escape variants.
Abstract: Additionally, a significantly higher frequency of G1896A and A1762T/G1764A mutations were found in HBeAg negative than in ACLF patients (p < 0.0001).
Abstract: Clonal sequencing of PCR-amplified HBV P/S and BCP/PC gene fragments was done and HBV diversity, frequency of immune escape (IE) and drug resistance (DR) mutations and mutations in BCP/PC gene (G1896A and A1762T/G1764A), were compared between each group.
HBV mutation literature information.
PMID: 
2017
Infection, genetics and evolution
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