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 HBV mutation literature information.


  Differences in HBV Replication, APOBEC3 Family Expression, and Inflammatory Cytokine Levels Between Wild-Type HBV and Pre-core (G1896A) or Basal Core Promoter (A1762T/G1764A) Mutants.
 PMID: 12931030       2003       Intervirology
Abstract: Five of 6 responders (83%) and none of the nonresponders had the A1762T/G1764A CP mutations (0/8, p < 0.003).


  Prevalence of HBV precore/core promoter variants in the United States.
 PMID: 12939588       2003       Hepatology (Baltimore, Md.)
Abstract: Variants in the precore (G(1896)A) and core promoter (A(1762)T, G(1764)A) regions of hepatitis B virus (HBV) may be related to serum HBV DNA levels and severity of liver disease.


  Evolution of hepatitis B virus sequence from a liver transplant recipient with rapid breakthrough despite hepatitis B immune globulin prophylaxis and lamivudine therapy.
 PMID: 12966541       2003       Journal of medical virology
Abstract: Sequence analysis of full-length viral genome before transplantation revealed many point mutations as compared with a wild-type genotype C sequence, including the T1753G/A1762T/G1764A triple mutation in the basal core promoter and the G1896A nonsense mutation in the precore region.


  An outbreak of fulminant hepatitis B in immunocompromised hemodialysis patients.
 PMID: 14614604       2003       Journal of gastroenterology
Abstract: RESULTS: All five patients had hepatitis B surface antigen (HBsAg) genotype C, a G-to-A stop codon mutation at nucleotide (nt) 1896 in the precore region, an A-to-T mutation at nt 1762 and an G-to-A mutation at nt 1764 in the basal core promoter.


  Characterization of two hepatitis B virus populations isolated from a hepatitis B surface antigen-negative patient.
 PMID: 11981772       2002       Hepatology (Baltimore, Md.)
Abstract: Both genomes possess the common A1762T-G1764A double mutation of the basal core promoter (BCP), and the genotype D virus is also mutated in the << TATA box >> of the large surface antigen promoter.


  Hepatitis B genotypes and precore/basal core promoter mutants in HBeAg-negative chronic hepatitis B.
 PMID: 11993512       2002       Journal of gastroenterology
Abstract: BACKGROUND: Mutations in the precore stop codon (G1896A) and the basal core promoter (A1762T and G1764A) are frequently found in hepatitis B envelope antigen (HBeAg)-negative chronic hepatitis B.


  Sequential analysis of hepatitis B virus core promoter and precore regions in cancer survivor patients with chronic hepatitis B before, during and after interferon treatment.
 PMID: 12010505       2002       Journal of viral hepatitis
Abstract: Five of the six (83%) responders displayed the double CP mutation A1762T/G1764A always in association with a T1753C change.


  In vivo suppression of precore mRNA synthesis is associated with mutations in the hepatitis B virus core promoter.
 PMID: 12033768       2002       Virology
Abstract: Precore mRNA synthesis was suppressed by the A1762T/G1764A mutation regardless of the presence of the precore stop codon mutation G1896A, suggesting that in addition to downregulating an immunomodulatory protein this double basic core promoter mutation may also confer a replication advantage to the virus.
Abstract: Our in vivo study shows therefore that the double A1762T/G1764A mutation is associated with the specific suppression of precore mRNA synthesis directed by the HBV core promoter.
Abstract: The double A1762T/G1764A


  Differences in HBV Replication, APOBEC3 Family Expression, and Inflammatory Cytokine Levels Between Wild-Type HBV and Pre-core (G1896A) or Basal Core Promoter (A1762T/G1764A) Mutants.
 PMID: 12210428       2002       Journal of medical virology
Abstract: Hepatitis B viruses (HBV) with core promoter mutations (A(1762)T, G(1764)A) were found in a previous study to be highly prevalent in patients from Guangxi, China with hepatocellular carcinoma (HCC).


  A case-control study for clinical and molecular biological differences between hepatitis B viruses of genotypes B and C. Japan HBV Genotype Research Group.
 PMID: 11124839       2001       Hepatology (Baltimore, Md.)
Abstract: The double mutation in the basic core promoter (A-to-T at nt 1762 and G-to-A at nt 1764), however, was significantly more frequent in genotype C than B patients (58% vs.



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