literature

HBV mutation literature information.

The nucleotide changes within HBV core promoter/precore during the first 12weeks of nucleos(t)ide treatment might be associated with a better virological response.

PMID: 28088502 2017 Infection, genetics and evolution

Abstract: The mutation rates of A1762T/G1764A and G1896A were found to decrease from 46.2% (24/52) at baseline to 36.5% (19/52) at week 12 (P=0.426) and from 28.8% (15/52) to 21.2% (11/52) (P=0.497), respectively.

Clinical features and viral quasispecies characteristics associated with infection by the hepatitis B virus G145R immune escape mutant.

PMID: 28325923 2017 Emerging microbes & infections

Result: With regard to the 'hot-spot' mutations in the HBV genome, G1896A in the preC region and A1762T/G1764A in the basic core promoter region were studied.

Sequence analysis and functional characterization of full-length hepatitis B virus genomes from Korean cirrhotic patients with or without liver cancer.

PMID: 28373061 2017 Virus research

Result: All the high replicating clones harbored A1762T/ G1764A mutations, and all but the three non-HCC clones harbored G1896A precore mutation.

Result: Consistent with the high prevalence of core promoter mutations in genotype C, especially at the advanced stages of liver diseases, 34 of the 36 clones (including all the 20 HCC-derived clones) harbored the A1762T/G1764A double mutation.

Result: Finally, the only two clones lacking A1762T/G1764A mutations (12.1 and 12.3 from a non-

Hepatitis B virus sequencing and liver fibrosis evaluation in HIV/HBV co-infected Nigerians.

PMID: 28376292 2017 Tropical medicine & international health

5Result: Fifteen (43%) had the double A1762T/G1764A mutation (""TA mutation"") in the BCP region; an additional patient had only G1764A."

8Discussion: The double A1762T/G1764A (""TA"" mutation) in the BCP region affects mRNA transcription and decreases HBeAg production.

Abstract: We identified BCP A1762T/G1764A in 15/35 (43%), PC G1896A in 20/35 (57%), 'a' determinant mutations in 12/45 (26.7%) and preS2 deletions in 6/16 (37.5%).

Complete genome sequencing and clinical analysis of intrahepatic hepatitis B virus cccDNA from HCC.

PMID: 28478205 2017 Microbial pathogenesis

Abstract: RESULTS: High frequencies of C1653T, T1753V, and A1762T/G1764A cccDNA mutations were observed in both tumor and non-tumor tissues.

The association between hepatitis B mutants and hepatocellular carcinoma: A meta-analysis.

PMID: 28489767 2017 Medicine

Abstract: A meta-analysis of pooled results from case-control studies examined the association between mutations G1896A, A1762T, G1764A, and A1762T/G1764A and the risk of HCC.

Abstract: CONCLUSION: In summary, we found that G1896A, A1762T, G1764A, and A1762T/G1764A are associated with an increased risk of HCC.

Abstract: RESULTS: We included 29 articles for analysis and found that G1896A (summary odds ratios [OR] = 2.04, 95% confidence interval [CI] = 1.41-2.95),

PMID: 28654219 2017 Journal of viral hepatitis

Abstract: Furthermore, these might be the possible reasons for higher occurrence of AG1762/1764TA as compared to A1762T and G1764A in cirrhosis and HCC patients.

Abstract: Hepatitis B virus (HBV) genomic mutations A1762T, G1764A and AG1762/1764TA cause production of HBV X protein (HBx) mutants, namely K130M, V131I and KV130/131MI.

Natural history of acute and chronic hepatitis B: The role of HBV genotypes and mutants.

PMID: 28774406 2017 Best practice & research. Clinical gastroenterology

Abstract: In chronic hepatitis B patients, genotype C and D have a higher frequency of basal core promoter A1762T/G1764A mutations than genotype A and B.

Molecular characterization of hepatitis B virus in Vietnam.

PMID: 28859616 2017 BMC infectious diseases

Abstract: A1762T and G1764 T mutations and a double mutation (A1762T and G1764 T) in the BCP region were significantly more frequent in genotype C1 isolates (p < 0.001).

Result: BCP/preC/core gene mutation: BCP mutations at T1753C, G1757A, A1762T, G1764 T and Result: A double mutation (A1762T and G1764A) was identified in 67.5% (25/37) of the C1 subgenotype isolates compared to 8.2% (8/98) of the genotype B isolates (p < 0.001).

Contribution of C1485T mutation in the HBx gene to human and murine hepatocarcinogenesis.

PMID: 28874700 2017 Scientific reports

Result: We found that the presence of a double core promoter mutation (A1762T and G1764A) correlated with the development of HCC, as reported previously (data not shown).

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