Abstract: RESULTS: Among the major mutant variants detected, double BCP mutations (A1762T/G1764A) (25.9%), Kozak sequences mutations (nt1809-1812) (51.7%) and the classical PC mutations such as A1814C/C1816T (15.4%), G1896A (25.2%) and G1862T (44.8%) were predominant mutant variants.
Result: Many of the BCP mutations showed no significant difference among the study groups except for the A1762T, G1764A and T1768A mutant variants (Table 2).
Result: The double BCP mutations (A1762T
A new hepatitis B virus e antigen-negative strain gene used as a reference sequence in an animal model.
PMID: 29339154
2018
Biochemical and biophysical research communications
Abstract: The main four point variants including A1762T, G1764A, G1896A, and G1899A were detected in the full-length genome.
Abstract: The strain will increase viral replication and infection for mutations A1762T and G1764A in the basal core promoter region, and mutations G1896A and G1899A in the pre-core region.
Human hepatocytes apoptosis induced by replication of hepatitis B virus subgenotypes F1b and F4: Role of basal core promoter and preCore mutations.
Result: There were no C1653T mutations, two (4.5%) T1753V mutations, five (11.4%) double mutations of A1762T/
Discussion: But looking at the promoter region mutations, G1613A mutation was identified in 10.3% of these 31 strains, C1653T was 0%, T1753V was 3.2%, A1762T/G1764A was 16.1%, and C1766T /T1768A was 3.2%.
Discussion: Reported promoter mutations are G1613A, C1653T, and T1753V single mutations and A1762T/G1764A double mutations.
Intergenotype recombinant analysis of full-length hepatitis B virus genomes from 516 Chinese patients with different illness categories.
Abstract: Difference in basal core promoter A1762T/G1764A mutations and precore G1896A mutation incidences was not significant between B/C recombinant and genotypes B or C virus, although the significance was there between genotypes B and C viruses.
Hepatitis B virus infection in children of HBV-related chronic liver disease patients: a study of intra-familial HBV transmission.
Abstract: Recognized mutations associated with HBsAg detection and/or vaccination failure, T140I, T143S/M, G145R, and Y161F, were identified in 20 subjects; while mutations linked to HBeAg-defective variants, PC G1896A and BCP A1762T/G1764A, were found in 7 and 11 subjects, respectively.
Effects of amino acid substitutions in hepatitis B virus surface protein on virion secretion, antigenicity, HBsAg and viral DNA.
Abstract: The precore/core mutations A1762T + G1764A (40.9%) were found mostly in genotypes A and D, and G1896A (29.55%) was more frequent in genotype D than in genotype A.
A novel hepatitis B virus subgenotype D10 circulating in Ethiopia.
HBV mutation literature information.
PMID: 
2018
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