Nucleotide Substitutions in Hepatitis B Viruses Derived from Chronic HBV Patients.
PMID: 31308922
2019
Mediterranean journal of hematology and infectious diseases
Conclusion: Furthermore, the present data indicate a high rate of G1896A mutant in the PC
Result: A1762T and G1764A were frequently detected together in 23.0% (6/26) of the isolates.
Result: However, none of the patients with A1762T/G1764A mutation carried the G1764T/C1766G mutant (Table 2).
Result: In the BCP region, the most common mutations were A1762T (30.0%, 8/26) and G1764T (30.0%, 8/26), followed by G1764A (26.0%, 7/26), C1766G (26.0%, 7/26), C1766T (11.5%, 3/26).
Nearly half of Ultrio plus NAT non-discriminated reactive blood donors were identified as occult HBV infection in South China.
Abstract: The C1505A mutation in X region, T1753V and A1762T/G1764A mutations in the basal core promoter region and C1858T in precore (PC) region were frequent and only detected in patients with ALD (28.9, 40, 73.5 and 17.6%, respectively), whereas the G1896A mutation in the PC region was frequently detected in HBV carriers.
A substitution in the pre-S1 promoter region is associated with the viral regulation of hepatitis B virus.
Introduction: Double mutations, A1762T and G1764A, in the basic core promoter region result in decreased HBeAg expression and enhanced viral genome replication; these mutations are frequently found in HBeAg-negative chronic hepatitis patients.
Discussion: The A1762T and G1764A mutations in the basic core promoter region are associated with an increased risk of HCC in genotype C patients.
HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism.
Discussion: Taken together, these results provide a potential mechanism whereby HBV encoding X_K130M/V131I (BCP_A1762T/G1764A) may contribute to the high rate of HCC observed clinically in patient cohorts containing these mutations.
Discussion: The X_K130M/V131I amino acid changes are encoded by nucleotide changes at BCP_A1762T/G1764A, which also result in a decrease in PC/C mRNA and subsequent HBeAg expression.
Naturally Occurring Mutations within HBV Surface Promoter II Sequences Affect Transcription Activity, HBsAg and HBV DNA Levels in HBeAg-Positive Chronic Hepatitis B Patients.
Introduction: For instance, it was found that A1762T/G1764A were novel mutations within CP and could lead to decreased HBeAg expression but enhanced viral replication, which correlated with liver disease severity.
Discussion: Whether single-site mutations may have such a significant effect on activity, we refer to the effects of the A1762T/G1764A mutation in HBV.
Hepatitis B virus in Mar del Plata, Argentina: Genomic characterization and evolutionary analysis of subgenotype F1b.
Abstract: In the HCC patients, T1938C and A2051C mutations in the core region had accumulated significantly with A1762T/G1764A mutations in the basal core promoter (BCP) region and G1896A mutation in the precore (PC) region.
Precore G1896A mutation is associated with reduced rates of HBsAg seroclearance in treated HIV hepatitis B virus co-infected patients from Western Africa.
Abstract: Baseline pcG1896A mutation was identified in 51 (59.3%) patients, who were more commonly HBeAg-negative (P < .001) and had basal core promotor A1762T/G1764A mutations (P < .001).
Human hepatocytes apoptosis induced by replication of hepatitis B virus subgenotypes F1b and F4: Role of basal core promoter and preCore mutations.
HBV mutation literature information.
PMID: 
2019
Mediterranean journal of hematology and infectious diseases
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