Abstract: It has been found that V29A strains, a BARF1 mutant subtype, showed higher prevalence in NPC, which may suggest the association between this variation and nasopharyngeal carcinoma (NPC).
Discussion:
Discussion: We have detected V29A BARF1 subtytpe in 20 of 79 (25.3 %) NPC, 0 of 45 (0 %) EBVaGC and 2 of 46 (4.3 %) TWs from healthy donors.
Discussion: reported that the V29A mutation in the transforming domain are not considered to change the structure of the protein, so may have little effect on its function.
Unique variations of Epstein-Barr virus-encoded BARF1 gene in nasopharyngeal carcinoma biopsies.
Abstract: V29A subtype, with one consistent amino acid change at residue 29 (V A) and several nucleotide changes, showed higher frequency in
Abstract: The relatively higher prevalence of type f/V29A/SPM strains in NPC may also suggest the association between these variations in multiple viral genes and NPC.
Abstract: Two major subtypes of BARF1 gene, designated as B95-8 and V29A, were identified.
Abstract: Type f isolates was specially correlated with the V29A/SPM genotype in NPC isolates and type f/V29A/SPM was preferentially found in NPC.
Conserved mutation of Epstein-Barr virus-encoded BamHI-A Rightward Frame-1 (BARF1) gene in Indonesian nasopharyngeal carcinoma.
Abstract: At the protein level these mutations resulted in 3 main substitutions (V29A, W72G, H130R), which are not considered to cause gross tertiary structure alterations in the hexameric BARF1 protein.
Discussion: Furthermore, BARF1 variants with 2 amino acid changes (V29A and H130R) most commonly detected in EBV isolates from the Discussion: Our preliminary data indicate that the Indonesian variant BARF1 (V29A and H130R) is rapidly secreted from human epithelial cells, has a stable hexameric structure and binds M-CSF (CSF-1) with high affinity (Hoebe et al., unpublished data).
EBV mutation literature information.
PMID: 
2018
Journal of medical virology
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