Result: Considering the conservation of amino acid mutation and the mutual exclusion of mutations at the site of AA 79 and AA 88, the NK/T cell lymphoma cases were divided into 3 subtypes: 79V88V, 79L88L and 79V88L, the former two subtype carrying L88V, V79L mutations respectively, while the latter one without amino acid substitutions at these two residues.
Result: alpha4 helix had the dominant mutation L88V in 41 samples (77.4 %).
Discussion: In Northern China, amino acid mutation L88V has been found in 26 of 39 (66.7 %) NPC, 34 (85.0 %) of 40 EBVaGC, and 41 (77.4 %) of 53 TW samples from healthy donors.
Discussion: These mutations were highly conservative with
Polymorphisms of Epstein-Barr virus BHRF1 gene, a homologue of bcl-2.
EBV mutation literature information.
PMID: 
2015
Virology journal
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