literature

EBV mutation literature information.

Conservation and polymorphism of EBV RPMS1 gene in EBV-associated tumors and healthy individuals from endemic and non-endemic nasopharyngeal carcinoma areas in China.

PMID: 29665370 2018 Virus research

Abstract: However, few studies have investigated the single-nucleotide polymorphisms (SNPs) of RPMS1, and only one SNP site (g155391a) has been reported to be associated with nasopharyngeal carcinoma occurrence.

Nasopharyngeal carcinoma risk prediction via salivary detection of host and Epstein-Barr virus genetic variants.

PMID: 29221111 2017 Oncotarget

Method: The most striking finding was a significant association between a single nucleotide polymorphism (SNP) in the EBV-encoded RPMS1 gene (locus 155391: G > A, referred to here as G155391A, resulting in the alternation of Asp to Asn) and NPC risk.

Discussion: Our independent analyses of the G155391A variant in EBV RPMS1 in tumor biopsy and throat washing from study population 1 and in saliva from study population 3 also consistently revealed its strong association with NPC

Discussion: Thus, G155391A in EBV RPMS1 could serve as a valuable indicator for high risk of NPC in southern China.

A single nucleotide polymorphism in the Epstein-Barr virus genome is strongly associated with a high risk of nasopharyngeal carcinoma.

PMID: 26675171 2015 Chinese journal of cancer

Result: The frequencies of SNP G155391A were counted and compared among samples from Guangdong in South China, which is an NPC endemic region, as well as in North China and Europe, where NPC incidence is relatively low.

Result: The increasing trend in the frequency of SNP G155391A in samples from regions with low to high NPC incidence was consistently observed in NPC patients, using either TW or TB samples (both P < 0.001; Table 5).

Result: The result revealed a consistently strong association between SNP G155391A and a high NPC

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