Result: These results demonstrate that F144I is the unique polymorphism responsible for the high NF-kappaB activation level mediated by A2.

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Discussion: This group of variants is more closely related to China1 than to the other LMP1 strains with F144I described by Edward

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Discussion: We identified F144I as responsible for the enhanced NF-kappaB by variant A2, which is a close relative of CAO and showed that all the variants we isolated in our study that carry isoleucine at position 144 display the same phenotype.

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