Discussion: Overall the pilot clinical study on the potential association of polymorphisms I124V/I152L and F144I/D150A/L151I with HL demonstrated the feasibility and interest of such an approach, even if the statistical power was too low to draw a definitive conclusion, which is a major limit of this study.
Discussion: Polymorphisms I124V/I152L and F144I/D150A/L151I were chosen as markers of enhanced NF-kappaB activation in a pilot epidemiological study within the SHCS.
Discussion: The linked polymorphisms _ENREF_33F144I/
Transmembrane peptides used to investigate the homo-oligomeric interface and binding hotspot of latent membrane protein 1.
Result: TM5 D150A migrated faster than wild type TM5, with an apparent molecular weight similar to that of the other LMP-1 TMs.
Result: The majority of LMP-1 negative cells in each transfected population (those cells that contained no detectable immunoreactive LMP-1, lyLMP-1 or LMP-1 D150A) contained <=14% nuclear p65.
Result: The number of LMP-1 D150A expressing cells with predominantly nuclear p65 was significantly less than that observed in wild type LMP-1 expressing cells (38% versus 78%, respectively).
Result: The oligomerization of TM1, TM5 and TM5 D150A was compared by ToxR assay (Figure 4B).|mgd
EBV mutation literature information.
PMID: 
2012
PloS one
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