Abstract: Variations in
LMP1 and
EBNA3B epitopes and mutations in Cp (
11404 C>T) and Qp (
50134 G>C) found in GD1, GD2 and HKNPC1 could potentially affect CD8(+) T cell recognition and latent gene expression pattern in
NPC, respectively.
Result: Although no mutations were identified in known and predicted TATA boxes, sequence changes of
11,324 G>T and
11,404 C>T in Cp, and
49,937 G>A and
50,134 G>C in Qp were observed.
Discussion: HKNPC1, GD1 and GD2 strains shared the Cp mutation (
11404 C>T), whereas only GD2 and HKNPC1 shared the Qp mutation (
50134 G>C).
EBV mutation literature information.
PMID: 
2012
PloS one
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