Abstract: The main SP-A haplotype, interactively with SP-B Ile131Thr polymorphism and with constitutional and environmental factors, influences the risk of RDS.
Involvement of influenza virus PA subunit in assembly of functional RNA polymerase complexes.
Abstract: Sequencing of the gene encoding ts53 PA and recombinant virus rescue experiments revealed that an amino acid change from Leu to Pro at amino acid position 226 is causative of temperature sensitivity.
Attenuating mutations of the matrix gene of influenza A/WSN/33 virus.
Abstract: In challenge studies, mice immunized by infection with R101S-R105S were fully protected from lethal challenge with A/WSN/33.
Abstract: In contrast, the double mutation R101S-R105S was synergistic and resulted in temperature sensitivity reflected by reduced viral replication at a restrictive temperature.
Abstract: Individual substitution, R101S or R105S, had a minimal effect on viral replication.
Abstract: The replication and attenuating properties of R101S-R105S suggest its potential in development of live influenza virus vaccines.
Abstract: The results from mouse studies indicated that the R101S-R105S dou
Hypothalamic growth hormone-releasing hormone (GHRH) deficiency: targeted ablation of GHRH neurons in mice using a viral ion channel transgene.
Abstract: In mammalian cells, (H37A)M2 forms a high conductance monovalent cation channel that can be blocked by the antiviral drug rimantadine.
Abstract: Transgenic mice with (H37A)M2 expression targeted to GHRH neurons developed postweaning dwarfism with hypothalamic GHRH transcripts detectable by RT-PCR but not by in situ hybridization and immunocytochemistry, suggesting that expression of (H37A)M2 had silenced or ablated virtually all the GHRH cells.
Abstract: We have adopted a novel approach to silence or ablate GHRH neurons, using a modified H37A variant of the influenza virus M2 protein ((H37A)M2).
A common polymorphism in the SFTPD gene influences assembly, function, and concentration of surfactant protein D.
PMID: 15661913
2005
Journal of immunology (Baltimore, Md.
Abstract: Genotyping for three single-nucleotide variations altering amino acids in the mature protein in codon 11 (Met(11)Thr), 160 (Ala(160)Thr), and 270 (Ser(270)Thr) of the SP-D gene was performed and related to the SP-D levels in serum.
Characterization of recombinant influenza B viruses with key neuraminidase inhibitor resistance mutations.
PMID: 15665027
2005
The Journal of antimicrobial chemotherapy
Abstract: An arginine to lysine change at position 291 (292 N2 numbering) mimicked that seen frequently in influenza A N2 clinical isolates resistant to oseltamivir.
Abstract: RESULTS AND CONCLUSIONS: With the exception of a virus containing the E116G mutation, mutant viruses were attenuated to different levels in comparison with wild-type virus.
Abstract: Similarly, an arginine to lysine change at position 149 (152 in N2 numbering) was made to reproduce the change found in the only reported zanamivir-resistant clinical isolate of influenza B virus.
YM-53403, a unique anti-respiratory syncytial virus agent with a novel mechanism of action.
Abstract: Consistent with this result, two YM-53403-resistant viruses have a single point mutation (Y1631H) in the L protein which is a RNA polymerase for both the transcription and replication of the RSV genome.
Chemical rescue of histidine selectivity filter mutants of the M2 ion channel of influenza A virus.
PMID: 15784624
2005
The Journal of biological chemistry
Abstract: Buffer molecules that were neutral when protonated (4-morpholineethanesulfonic acid and 3-morpholino-2-hydroxypropanesulfonic acid) did not rescue ion channel activity of the M2-H37G mutant ion channel, but 1-methylimidazole did provide partial rescue of function.
Abstract: Chemical rescue was demonstrated for three histidine substitution mutant ion channels (M2-H37G, M2-H37S, and M2-H37T) and for two double mutants in which the Trp-41 channel gate was also mutated (H37G/W41Y and H37G/W41A).
Abstract: Currents of the M2-
Pathogenesis of Hong Kong H5N1 influenza virus NS gene reassortants in mice: the role of cytokines and B- and T-cell responses.
PMID: 15784906
2005
The Journal of general virology
Abstract: Here, in a mouse model, H1N1 A/Puerto Rico/8/34 (PR/8) reassortants that contained the H5N1/97 NS gene, the H5N1/01 NS gene, or an altered H5N1/97 NS gene encoding a Glu92-->Asp substitution in NS1 was studied.
Improvement of influenza A/Fujian/411/02 (H3N2) virus growth in embryonated chicken eggs by balancing the hemagglutinin and neuraminidase activities, using reverse genetics.
Abstract: Alternatively, recombinant A/Fujian/411/02 virus could be adapted to grow in eggs by two amino acid substitutions in the HA molecule (H183L and V226A), which also resulted in the increased HA receptor-binding activity.
Abstract: It was determined that replication of A/Fujian/411/02 in eggs could be improved by either changing minimum of two HA residues (G186V and V226I) to increase the HA receptor-binding ability or by changing a minimum of two NA residues (E119Q and Q136K) to lower the NA enzymatic activity.
IV mutation literature information.
PMID: 
2006
Seminars in perinatology
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