Abstract: D197N reduced inhibition by all NAIs in BR/08 but only by oseltamivir and peramivir in PH/13; R150K caused HRI by all NAIs in PH/13.
Abstract: E105K, R150K, and D197N attenuated replication efficiency of BR/08 in vitro and in mice; only E105K had this effect in PH/13.
Abstract: In both backgrounds, I221 L/N/T/V resulted in reduced or highly reduced inhibition (HRI) by one to three currently available NAIs.
Abstract: Notably, the I221 L/N/T/V substitutions did not severely impair replication, particularly in PH/13.
Abstract: To impro
The influenza NS1 protein modulates RIG-I activation via a strain-specific direct interaction with the second CARD of RIG-I.
PMID: 31843969
2020
The Journal of biological chemistry
Abstract: Furthermore, we determined that the R21Q mutation does not impede the interaction between NS1 and TRIM25 or NS1RBD's ability to bind RNA.
Abstract: Here we investigate the functional consequences of an R21Q mutation on NS1's ability to antagonize RIG-I signaling.
Abstract: In support of this, we determined that an R21Q mutation in NS1 results in a marked deficit in NS1's ability to antagonize TRIM25-mediated ubiquitination of the RIG-I CARDs, a critical step in RIG-I activation.
Abstract: We also identified that a single strain-specific polymorphism in the NS1RBD (R21Q) completely abrogates this interaction.
Abstract: We also observed that WT NS1<
Agathisflavone, a Biflavonoid from Anacardium occidentale L., Inhibits Influenza Virus Neuraminidase.
PMID: 31854280
2020
Current topics in medicinal chemistry
Abstract: Sequential passages of the virus in the presence of agathisflavone revealed the emergence of mutation R249S, A250S and R253Q in the NA gene.
Influenza A/H4N2 mallard infection experiments further indicate zanamivir as less prone to induce environmental resistance development than oseltamivir.
PMID: 31855133
2020
The Journal of general virology
Abstract: Two neuraminidase substitutions emerged, H274N (ZA IC50 increased 5.5-fold) and E119G (ZA IC50 increased 110-fold) at 10 and 100 microg l-1 of ZA, respectively.
Sporadic occurrence of H9N2 avian influenza infections in human in Anhui province, eastern China: A notable problem.
Abstract: None of the human-isolated H9N2 AIVs had the I368V mutation in PB1 protein, but all the poultry-isolated H9N2 viruses in 2017 carried this mutation.
Neuraminidase from Influenza A and B Viruses is Susceptible to the Compound 4-(4-Phenyl-1H-1,2,3-Triazol-1-yl)-2,2,6,6-Tetramethylpiperidine-1- Oxyl.
PMID: 31880262
2020
Current topics in medicinal chemistry
Abstract: When we passaged the influenza A virus in the presence of Tritempo, a mutant virus with the G248P change in the NA was detected.
Identification of a Permissive Secondary Mutation That Restores the Enzymatic Activity of Oseltamivir Resistance Mutation H275Y.
1Abstract: Compared to the M2 ""wild type"" (WT) with valine at position 27, we observe that the channel pore is wider at its N-terminus as a result of the V27A mutation and that this removes V27 side chain hydrophobic interactions that are important for binding of amantad
Abstract: A 300 ns molecular dynamics simulation of the M2(22-46) V27A-spiro-adamantyl amine complex predicts with accuracy the position of the ligands and waters inside the pore in the X-ray crystal structure of the M2(22-46) V27A complex.
Abstract: Additionally, in the structure of the M2(21-61) V27A construct, the C-terminus of the channel is tightly packed relative to that of the M2(22-46) construct.
Contribution of Fc-dependent cell-mediated activity of a vestigial esterase-targeting antibody against H5N6 virus infection.
Result: 9F4-K322A treated mice also showed reduced tissue damage and polymorphonuclear cell inflammation compared to 1A4 treated mice, albeit to a lesser extent compared to mice that received 9F4-WT (Figure 5D and E).
Result: 9F4-WT and 9F4-K322A treated mice had similar lung virus titres at 4 dpi and were both significantly lower compared to mice treated with 1A4 (Figure 5C).
Result: All infected mice that were treated with 9F4-WT or 9F4-K322A survived the rgPR8 H5N6 challenge (Figure 5B).
Result: Collectively these observations suggest that 9F4-K322A has similar anti-H5N6 potency compared to 9F4-WT and that CDC is dispensable for 9F4's capability to protect against H5N6 in vivo.
Result: In contrast, infected mice treated with 9F4-K322A lost approximately 5% body weight between 1 and 3 dpi b
The effect of mutations derived from mouse-adapted H3N2 seasonal influenza A virus to pathogenicity and host adaptation.
Abstract: Additionally, the PB2 F323L mutation presented delayed but elevated replication competence in the respiratory tract, whereas the <
Introduction: Additionally, the function of the NP D34N mutation is not yet known but might be related to interactions with PB2.
Introduction: Furthermore, the E627K and D701N substitutions in the PB2 gene have been commonly detected in mouse-adapted IAVs and related to enhanced virulence in mice.
Introduction: The NP N319K mutation enhances interactions with importin alpha1, which increases nuclear import of ribonucleoprotein (RNP).
Optimization of 4-Aminopiperidines as Inhibitors of Influenza A Viral Entry That Are Synergistic with Oseltamivir.
PMID: 32069052
2020
Journal of medicinal chemistry
Abstract: Compound 16 displayed a significant decrease of viral titer when evaluated in the infectious assays with influenza virus H1N1 (A/Puerto Rico/8/1934) or H5N1 (A/Vietnam/1203/2004) strains and the oseltamivir-resistant strain with the most common H274Y mutation.
IV mutation literature information.
PMID: 
2020
Antiviral research
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