Abstract: Like wild-type tax, many of them (C23W, A108T, L159F, and L235F) transactivate both the HTLV-LTR and the NF-kappaB reporters.
Abstract: One of them, V19M, preferentially activates NF-kappaB, but is attenuated for LTR activation.
Introduction: C23W, A108T, L159F, and L235F transactivated both the HTLV-LTR and the NF-kappaB reporters.
Introduction: Five mutants (V19M, C23W, A108T, PMID: 17577584
2007
Biochemical and biophysical research communications
Abstract: Here we show that the reduced fusion activity of an I334A mutant correlated with a decrease in stability of the gp21 trimer of hairpins conformation, in the context of a maltose-binding protein-gp21 chimera.
The role of WWP1-Gag interaction and Gag ubiquitination in assembly and release of human T-cell leukemia virus type 1.
Abstract: Furthermore, the K74R mutation rendered assembly hypersensitive to C2WW inhibition; K74R Gag budding was inhibited at significantly lower levels of expression of C2WW compared with wild-type Gag.
Abstract: Virus-like particles produced by the K74R mutant did not contain ubiquitinated MA and showed a fourfold reduction in the release of infectious particles.
Distribution of human T cell lymphotropic virus type 1 (HTLV-1) subtypes in Brazil: genetic characterization of LTR and tax region.
PMID: 17067264
2006
AIDS research and human retroviruses
Abstract: Five specific nucleotide substitutions, C7401T, T7914C, C7920T, C7982T, and G8231A, were highly conserved among the Brazilian isolates (79.6%), with a frequency ranging from 81.6% to 100% in the sample group and from 18.4% to 24.1% in the prototypes used, suggesting the existence of a molecular signature.
In vivo analysis of replication and immunogenicity of proviral clones of human T-lymphotropic virus type 1 with selective envelope surface-unit mutations.
Abstract: In vitro assays indicate that HTLV-1 envelope (Env) Ser75Ile, Asn95Asp, and Asn195Asp surface unit (SU) mutants are able to replicate in and immortalize lymphocytes.
Naturally occurring substitutions of the human T-cell leukemia virus type 1 3' LTR influence strand-transfer reaction.
PMID: 12711052
2003
Journal of virological methods
Abstract: By contrast, a single G-->A transition at position 52 was found to result in 33% gain of function.
Abstract: Furthermore, a C-->T transition at 41 bp from the provirus 3' end decreased the reaction efficiency by 80%.
The central region of human T-cell leukemia virus type 1 Tax protein contains distinct domains involved in subunit dimerization.
Abstract: Moreover, the Tax mutants M22 (T130A and L131S) and M29 (K189A and R190S), with amino acid substitutions located in DD1 and DD2, respectively, were found to be impaired in Tax self-association.
KIX-mediated assembly of the CBP-CREB-HTLV-1 tax coactivator-activator complex.
Abstract: Moreover, a mutant Tax of coactivator CBP-binding site (K88A), which activated NF-kappaB but not CREB pathway, could not repress the p73 nor p51 trans-activation functions, indicating that CBP-binding domain of Tax is essential for the suppression of their functions.
Kinase-inducible domain-like region of HTLV type 1 tax is important for NF-kappaB activation.
PMID: 11080799
2000
AIDS research and human retroviruses
Abstract: Here we report that single (K88A, V89A, L90A) and double alanine substitutions (V89A-L90A) in the (88)KVL(90) motif attenuate the ability of Tax to activate NF-kappaB.
Abstract: In contrast, although the L90A mutant is similarly attenuated for NF-kappaB activation, it showed significant activity in LTR trans-activation.
Abstract: Incorporation of both V89A and L90A substitutions in a V89A-L90A double mutant further reduced NF-kappaB activation and completely abrogated LTR trans-activation.
HTLV1 mutation literature information.
PMID: 
2007
Retrovirology
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