Polymorphisms in HTLV-1 Tax-responsive elements in HTLV-1-associated myelopathy/tropical spastic paraparesis patients are associated with reduced proviral load but not with disease progression.
PMID: 34494950
2021
The Journal of general virology
Abstract: By contrast, an LTR A125G mutation in TRE was associated with slightly reduced PVL only in HAM/TSP patients, although it did not influence the speed of disease progression.
Prevalence and evolutionary analyses of human T-cell lymphotropic virus in Guangdong province, China: Transcontinental and Japanese subtype lineages dominate the prevalence.
Abstract: Specially, 13 out of 39 transcontinental subtype sequences were characterized with L55P mutation and 21 out of 55 sequences were characterized with L19F mutation in viral gp46 protein.
Abstract: The L55P mutation seemed be specific to eastern Asia since it only presented in the sequences from Japan, mainland China, and Taiwan.
Molecular characterization of HTLV-1 genomic region hbz from patients with different clinical conditions.
Abstract: The R119Q mutation is possibly a protective factor as the frequency is higher in AC sequences.
Abstract: The analises showed that the R119Q mutation seems to be related to HTLV-1 clinical conditions since the frequency of this HBZ mutation is significantly different in comparison between AC with HAM/TSP and ATLL.
The N93D mutation of the human T-cell leukemia virus type 1 envelope glycoprotein found in symptomatic patients enhances neuropilin-1 b1 domain binding.
PMID: 34343702
2021
Biochimica et biophysica acta. Proteins and proteomics
Abstract: However, it remains unclear how the SU-N93D mutation affects Nrp1 b1 binding.
Abstract: Our results suggest that the interaction of SU Asp93 with the four residues of Nrp1 b1 renders the high affinity of the N93D mutant for Nrp1 b1 binding during HTLV-1 entry.
Abstract: Recently, the N93D mutation in the Nrp1 b1 binding region of the SU was identified in symptomatic patients with HTLV-1 infections in the Brazilian Amazon.
Abstract: The SU-N93D peptide binds directly to Nrp1 b1 with a binding affinity of 3.5 muM, which is approximately two-fold stronger than wild-type.
Abstract: This stronger binding is likely a result of the interaction between the substituted residue Asp93 of the N93D peptide and the four residues Trp301, Lys347, Glu348
The human T-cell leukemia virus type-1 tax oncoprotein dissociates NF-kappaB p65(RelA)-Stathmin complexes and causes catastrophic mitotic spindle damage and genomic instability.
Abstract: The Tax-G148V mutant, defective for NF-kappaB activation, exhibited reduced p65RelA-Stathmin binding and diminished genomic instability and cytotoxicity.
The N93D mutation of the human T-cell leukemia virus type 1 envelope glycoprotein found in symptomatic patients enhances neuropilin-1 b1 domain binding.
Abstract: Of the three most frequent mutations, the previously undescribed N93D mutant was invariably associated with symptomatic cases.
Abstract: The identification of a rare mutation (N93D), present only in symptomatic patients, should also be investigated further as a potential clinical marker.
Abstract: The rare N93D amino acid mutation may be associated with the clinical manifestations of this viral infection.
Result:
Result: All the cases with the N93D mutation also presented pain, sensitivity, and dysautonomia.
Result: Just over half (52.5%; 21) of the 40 samples analyzed in this study presented some type of amino acid mutation, with three types - S72G, N93D and S192P - being recorded most frequently (Table 3).
Analyses of HTLV-1 sequences suggest interaction between ORF-I mutations and HAM/TSP outcome.
PMID: 27553711
2016
Infection, genetics and evolution
Result: A combined classification of proviral load and clinical diagnosis reveals mutations D26N and F61L are associated with low proviral load and HC, whereas mutations S63P and R83C are associated with high proviral load and HAM/TSP (Figure 1C).
Result: Among them, only the P45L mutation is located within the motif previously described (HBZ nuclear localization signal) and was found more frequently between patients with HAM/TSP and high proviral load.
Result: As shown in Figure 1A, mutations P45L, S69G and
PMID: 26472535
2016
AIDS research and human retroviruses
Abstract: Although those mutations were not present in previously determined TFBS, one of those mutations (G306C/A) was present in an Sp-1 binding site determined by in silico analysis, and its presence abrogated the site for Sp-1 binding and created a new possible ATF binding site.
Abstract: Three mutations were statistically significant using the Fisher nonparametric test between the groups but were not present in previously determined TFBS (G126C/T, G306C, and C479T).
Low Proviral Load is Associated with Indeterminate Western Blot Patterns in Human T-Cell Lymphotropic Virus Type 1 Infected Individuals: Could Punctual Mutations be Related?
Abstract: Mutations in the distal and central regions of Tax Responsive Elements (TRE) 1 and 2 of G3 were observed, though not associated with PVL.The 8403A>G mutation of the distal region, previously related to high PVL, was absent in G3 but present in 50% of WB+ samples (p = 0.03).
Introduction: have reported an association between G232A in the Tax Responsive Element (TRE) 1 and an increase in PVL levels.
Result: Regarding the TRE-2, two punctual mutations (8522T>C, 8545G>A) were observed in sample N 50, while the other three were present in most Argentine sequences.
Result: The remaining mutations (H43P and M154V) were detected in sequences N 46 and 47, respectively;
The prevalence of human T-lymphotropic virus infection among blood donors in southeast China, 2004-2013.
Abstract: Interestingly, 12 of 25 Transcontinental subtype sequences harbored a characteristic L55P mutation in viral gp46 protein, which was only presented in the Transcontinental subtype sequences from Japan and Taiwan but not in that from other countries.
Result: A characteristic L55P mutation in the receptor binding domain (RBD) of gp46 protein was presented in 12 sequences (48.0%) of Transcontinental subtype.
Result: The comparison indicated that the L55P mutation was only observed in Transcontinental subtype strains originated from Japan (9/20, 45.0%), Taiwan (4/11, 36.4%) and China (1/2, 50%), but not appeared in strains isolated from Transcontinental subtype strains originated from other Asia countries (0/3), Africa (0/6), Central America (0/29), Europe (0/22), North America (0/12), South America (0/3
HTLV1 mutation literature information.
PMID: 
2021
The Journal of general virology
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