ViMRT
}  
 
Home   
< Docs   

 HPV mutation literature information.


  HPV16 E6 mutations and p53 codon72 polymorphism among women with cervical intraepithelial neoplasia 2 and 3 in China.
 PMID: 29787003       2016       European journal of gynaecological oncology
Abstract: CONCLUSION: HPV16 E6 T178G mutation increases the disease risk of CIN2, 3.
Abstract: RESULTS: Among the 85 amplified HPV sequences, point mutations such as T178G, T350G, G132A, A442C, T310G, G94T, C551A, etc.
Abstract: The rate of HPV16 E6 mutation T178G in CIN2, 3 group was significantly higher than that in normal and CINI group, i.e., in the 112 amplified p53 codon72 sequences, the distribution of Pro/Pro genotype in normal, and  PMID: 27977741       2016       PloS one
Abstract: We also found that a lineage B-specific mutation K93R (A379G) was associated with an increased risk of cervical neoplasia.
Result: Lineage C also harbored lineage-specific variations (Table 3), of which an E6 nonsynonymous mutation (L83V, concurrent mutations of C348G and G350T) and five E7 nonsynonymous mutations, S52D (concurrent mutations of A706G and G707A), Y55D (T727G), H61Y (C733T), D64N ( PMID: 27694853       2016       Scientific reports
Abstract: We have previously designed a high affinity bivalent protein binder for the E6 protein, a fusion between a helix from the E6 associated protein and PDZO9, an engineered variant (L391F/K392M) of the second PDZ domain from synapse associated protein 97 (SAP97 PDZ2).
Introduction: PDZO9, in turn, was selected from a library of pWT PDZ2 variants using phage display and it carries two additional mutations as compared to pWT PDZ2, L391F and K392M.
Introduction: The L391F mutation is loc
Introduction: pWT PDZ2 has two mutations as compared to wild type SAP97 PDZ2 (I342W and C378A) and is the variant used in our previous studies on the binding of SAP97 PDZ2.


  HPV16 variants distribution in invasive cancers of the cervix, vulva, vagina, penis, and anus.
 PMID: 27654117       2016       Cancer medicine
Abstract: Frequencies for alleles in the HPV16 E6 T350G polymorphism were similar across anogenital cancers from the same geographical origin.
Abstract: We have assessed the contribution of geography and anatomy to the differential prevalence of HPV16 variants and to the nonsynonymous E6 T350G polymorphism.
Introduction: Further, a large body of experimental research on the differential biological activiti
Method: Distribution of the polymorphic site T350G within HPV16_A1 variants was assessed by Pearson's chi-square test when stratified by geographical origin and by Fisher's test when stratified by anatomical location.


  The Human Papillomavirus 16 E7 Oncoprotein Attenuates AKT Signaling To Promote Internal Ribosome Entry Site-Dependent Translation and Expression of c-MYC.
 PMID: 27030265       2016       Journal of virology
Abstract: Attenuation of phosphorylated AKT (pAKT) by E7 was independent of the Rb degradation function of E7 but could be ablated by a missense mutation in the E7 carboxy terminus, H73E, thereby defining a novel structure-function phenotype for E7.


  Association of human papillomavirus type 16 and its genetic variants with cervical lesion in Korea.
 PMID: 27546189       2016       APMIS
Abstract: The most commonly observed LCR variations were 7521G>A (91.5%), 7730A>C (59.6%), and 7842G>A (59.6%).


  Identification of human papillomavirus-16 E6 variation in cervical cancer and their impact on T and B cell epitopes.
 PMID: 25800725       2015       Journal of virological methods
Abstract: Interestingly, the presence of variation H78Y and L83V result in creation of four new epitopes for the HLA-DQA1*0101/DQB1*0501.


  Identification and validation of immunogenic potential of India specific HPV-16 variant constructs: In-silico &in-vivo insight to vaccine development.
 PMID: 26507515       2015       Scientific reports
Abstract: In the present study, L500F (V16) variation showed a significant ~2.7 fold (p < 0.002) increase in antibody titer, whereas T379P (V8) showed ~0.4 fold (p < 0.328) decrease after final injection.
Result: -61.67 for V8R and -54.60 for V8V, where as in for V16R and V16V were -49.55 and 50.86, respectively.
Result: In 13 biallaelic variations, six variations C6163A(V1), G6171A(V2), C6240G(V3), A6432G(V6), G6693A(V8) and C6863T(V11) were missense and seven variations T6245C(V4), A6314G


  Association of human papillomavirus 16 E6 variants with cervical carcinoma and precursor lesions in women from Southern Mexico.
 PMID: 25889023       2015       Virology journal
Abstract: Eight new E6 variants were found and 2 of them lead to amino acid change: E-C183/G350 (I27T) and E-C306/G350 (K68T).
Introduction: Other polymorphisms including A131G, G132C, C143G, G145T, G176A, T178G and C335T generate the amino acid changes R10G/I, Q14H/D, D25E/N, I27R and H78Y, respectively.
Introduction: Several reports have shown the presence of common polymorphisms that generate amino acid changes in the


  Mutation detection of E6 and LCR genes from HPV 16 associated with carcinogenesis.
 PMID: 25735347       2015       Asian Pacific journal of cancer prevention
Abstract: In the E6 sequences, the most common mutation was T350G (L83V), detected in 67% of the samples, associated with increased risk of persistent infection.
Abstract: The most frequent mutation in LCR sequences was G7521A, in 80% of the analyzed samples; it affects the binding site of a transcription factor that could contribute to carcinogenesis.



Browser Board

 Co-occurred Entities




   Filtrator