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 HPV mutation literature information.


  Naturally Occurring Variations Modulate the Activity of the HPV33 Early Promoter and its Affinity for the E2 Transcription Factor.
 PMID: 30301935       2018       Scientific reports
Abstract: A7874C, which lies within an E2-binding sequence, is also shown to increase the activity and binding of E2 at this site.
Abstract: In contrast, the three variations most active in HeLa cells were C7537A, A7874C and A7879G.
Abstract: Remarkably, the two variations with the greatest effect on the EP in PHK were C7732G and a 79-bp deletion that were associated with high-grade cervical lesions and persistent infections, respectively, in epidemiological studies.
Introduction: In this manuscript, we used luciferase reporter-gene assays to characterize the EP activity of different HPV33 variants containing 79del and/or C7732G and spannin


  HPV16 E2 variants correlated with radiotherapy treatment and biological significance in cervical cell carcinoma.
 PMID: 30081093       2018       Infection, genetics and evolution
Abstract: Amino acid changes T135 K, A143T, N203D and P208A in the amino-terminal region were the most common mutations across the irradiated samples.
Abstract: Rather, the mutations in the carboxy-terminal region (T3694A and T3805G) were synonymous changes.


  The HPV16 E1 Carboxyl Domain Provides a Helper Function for Adeno-Associated Virus Replication.
 PMID: 30654371       2018       Intervirology
Abstract: METHODS: Rep78-E1 interaction was analyzed by Gal4-based yeast two-hybrid (Y2H)-cDNA assay.
Abstract: RESULTS: Gal4-Y2H- cDNA assay found in vivo Rep78-E1-binding activity across E1, but the carboxyl-third (amino acids [aa] 421-649) of E1 contained the predominant DNA replication helper domain.


  Genetic variability and lineage phylogeny of human papillomavirus type 45 based on E6 and E7 genes in Southwest China.
 PMID: 29981762       2018       Virus research
Abstract: Eleven nucleotide polymorphism sites were observed in the HPV45 E6 sequences, with 6 synonymous (C134T, T163C, A284C, T341C, T482C, A497G) and 5 non-synonymous (A124C, C157T, T162A, G259T, G487A) mutations.
Abstract: Six nucleotide polymorphism sites were observed in the E7 sequences, with 5 non-synonymous (G600A, A603C, A769C, G808T, G832T) and 1 sy


  The association of human papillomavirus type 16 E2 variations with cervical cancer in a Han Chinese population.
 PMID: 30008422       2018       Infection, genetics and evolution
Abstract: In the subgroup analysis, the frequency of the T3575G (S274A) variation in the EUR variant was significantly different between the case and control groups (P = 0.029); however, there was no significant difference in the frequency of the variations in the As variant between the case and control groups.


  A naturally occurring variant of HPV-16 E7 exerts increased transforming activity through acquisition of an additional phospho-acceptor site.
 PMID: 27829177       2017       Virology
Abstract: A common E7 variant encodes an amino acid change at N29S.
Abstract: Biologically, these biochemical differences are reflected in an increased ability of the N29S variant to transform primary rodent cells.
Abstract: This is the first study to demonstrate an important biochemical change in E7 function caused by a naturally occurring variation, and we suggest that the N29S variant merits further assessment to determine whether it has an increased association with the development of HPV-associated malignancies.


  HPV16 E6 polymorphism and physical state of viral genome in relation to the risk of cervical cancer in women from the south of Poland.
 PMID: 27801430       2017       Acta biochimica Polonica
Abstract: For the first time, missense mutations G122A, C153T and G188A were discovered in EUR-350G variant.


  Naturally occurring capsid protein variants L1 of human papillomavirus genotype 16 in Morocco.
 PMID: 28959092       2017       Bioinformation
Result: T389P amino acid substitution is located in the H-I loop; the two substitutions M424I and
Result: Among them, 5 were non-synonymous amino acids variations including A6693C observed in 18 cases, G6800A in 2 cases, G6818A in 2 cases.
Result: In Helice 2 region, the two mutations Met/Ile at position 425 and Met/Ile at position 431 are not significant as compared to the reference sequence.
Result: In the third pattern, reported in only 2 cases, all non-synonymous mutations were reported (Thr389Pro, Met424Ile, Met430Ile, ATC insertion at position 6901/6902 and the deletion of GAT at position 6950).


  The Cellular DNA Helicase ChlR1 Regulates Chromatin and Nuclear Matrix Attachment of the Human Papillomavirus 16 E2 Protein and High-Copy-Number Viral Genome Establishment.
 PMID: 27795438       2017       Journal of virology
Result: Following on from our previous experiments showing that BPV1 E2 associates with ChlR1 and that mutation of tryptophan 130 to arginine (W130R) abrogates ChlR1 binding, we aimed to determine whether this interaction surface is conserved in the HPV16 E2 protein.
Result: This was somewhat surprising because the Y131A mutation is not within the known nuclear localization signals in E2.
Result: To determine the biological significa
Table: D124A


  Identification of the impact on T- and B- cell epitopes of human papillomavirus type-16 E6 and E7 variant in Southwest China.
 PMID: 27693214       2017       Immunology letters
Abstract: E6 72-83 for HLA-A*02:01 and E6 74-84 for HLA-B*15:02 maybe are the new direct for therapeutic vaccine aimed at L83V variants.
Abstract: For the B-cell epitopes, three most potent epitopes for E6 were listed, and N29S lead the growth of score from 0.81 to 0.83.
Abstract: The mutations of D25E and L83V of E6 and N29S of E7 produce new epitopes, and the percentile values change with them.



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