Abstract: A7874C, which lies within an E2-binding sequence, is also shown to increase the activity and binding of E2 at this site.
Abstract: In contrast, the three variations most active in HeLa cells were C7537A, A7874C and A7879G.
Abstract: Remarkably, the two variations with the greatest effect on the EP in PHK were C7732G and a 79-bp deletion that were associated with high-grade cervical lesions and persistent infections, respectively, in epidemiological studies.
Introduction: In this manuscript, we used luciferase reporter-gene assays to characterize the EP activity of different HPV33 variants containing 79del and/or C7732G and spannin
HPV16 E2 variants correlated with radiotherapy treatment and biological significance in cervical cell carcinoma.
PMID: 30081093
2018
Infection, genetics and evolution
Abstract: Amino acid changes T135 K, A143T, N203D and P208A in the amino-terminal region were the most common mutations across the irradiated samples.
Abstract: Rather, the mutations in the carboxy-terminal region (T3694A and T3805G) were synonymous changes.
The HPV16 E1 Carboxyl Domain Provides a Helper Function for Adeno-Associated Virus Replication.
Abstract: METHODS: Rep78-E1 interaction was analyzed by Gal4-based yeast two-hybrid (Y2H)-cDNA assay.
Abstract: RESULTS: Gal4-Y2H- cDNA assay found in vivo Rep78-E1-binding activity across E1, but the carboxyl-third (amino acids [aa] 421-649) of E1 contained the predominant DNA replication helper domain.
Genetic variability and lineage phylogeny of human papillomavirus type 45 based on E6 and E7 genes in Southwest China.
Abstract: Eleven nucleotide polymorphism sites were observed in the HPV45 E6 sequences, with 6 synonymous (C134T, T163C, A284C, T341C, T482C, A497G) and 5 non-synonymous (A124C, C157T, T162A, G259T, G487A) mutations.
Abstract: Six nucleotide polymorphism sites were observed in the E7 sequences, with 5 non-synonymous (G600A, A603C, A769C, G808T, G832T) and 1 sy
The association of human papillomavirus type 16 E2 variations with cervical cancer in a Han Chinese population.
PMID: 30008422
2018
Infection, genetics and evolution
Abstract: In the subgroup analysis, the frequency of the T3575G (S274A) variation in the EUR variant was significantly different between the case and control groups (P = 0.029); however, there was no significant difference in the frequency of the variations in the As variant between the case and control groups.
A naturally occurring variant of HPV-16 E7 exerts increased transforming activity through acquisition of an additional phospho-acceptor site.
Abstract: A common E7 variant encodes an amino acid change at N29S.
Abstract: Biologically, these biochemical differences are reflected in an increased ability of the N29S variant to transform primary rodent cells.
Abstract: This is the first study to demonstrate an important biochemical change in E7 function caused by a naturally occurring variation, and we suggest that the N29S variant merits further assessment to determine whether it has an increased association with the development of HPV-associated malignancies.
HPV16 E6 polymorphism and physical state of viral genome in relation to the risk of cervical cancer in women from the south of Poland.
Conclusion: The study highlights the presence of T390P mutation, located in the H-I loop and could interact with vaccines induced monoclonal antibodies suggesting a potential impact of this mutation on the efficacy of available anti-HPV vaccines.
Discussion: M424I and M430I amino acid substitutions are located in the H4 helice whereas the Ser insertion is located in the H2 helice.
Discussion: Of particular interest, all the isolates analyzed differ from the reference sequence by the insertion of an ATC codon at position 6903 and deletion of GAT at positions 6951/2/3.
Discussion: Of particular interest, fine-mapping of the epitope footprint showed that the five non-synonymous changes of amino acids residues, including the ATC insertion and GAT deletion, are localized in the H2 and H4 helices and H-I and B-C loop regions PMID: 27795438
2017
Journal of virology
Result: Following on from our previous experiments showing that BPV1 E2 associates with ChlR1 and that mutation of tryptophan 130 to arginine (W130R) abrogates ChlR1 binding, we aimed to determine whether this interaction surface is conserved in the HPV16 E2 protein.
Result: This was somewhat surprising because the Y131A mutation is not within the known nuclear localization signals in E2.
Result: To determine the biological significa
Table: D124A
Table: D173A
Table: E118A
Table: H130R
Table: K177A
Table: Y131A
Identification of the impact on T- and B- cell epitopes of human papillomavirus type-16 E6 and E7 variant in Southwest China.
HPV mutation literature information.
PMID: 
2018
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