Human Papillomavirus Type 16 E1 Mutations Associated with Cervical Cancer in a Han Chinese Population.
PMID: 31341418
2019
International journal of medical sciences
Abstract: In the sub-lineage analysis, the differences in the T933A (A23A), T1014G (D50E) and G2160A (R432R) mutations were statistically significant between the case and control groups for the A4 (As) sub-lineage (P<0.05), and the differences in the T2232C (F456F), G2337A (M491I) and A2547G (P561P) mutations were statistically significant between the case and control groups for the A1-A3 (EUR) sub-lineage (P<0.05).
Introduction: reported that the A1668G, G2073A, T21
Mutational landscape and intra-host diversity of human papillomavirus type 16 long control region and E6 variants in cervical samples.
Abstract: Moreover, the most frequent mutations, both in samples from this study and in the available sequences from Mexican isolates in the GenBank database were LCR-G7518A, which is involved in carcinogenesis, and E6-T350G (producing L83V), associated with persistence of infection.
Distribution of HPV 16 E6 gene variants in screening women and its associations with cervical lesions progression.
Abstract: Interestingly, in patients with suspected cervical lesions the most prevalent variant was As variant (54.9%) by increasing significance with severity of cervical diseases (OR 4.337; 95% CI 1.248-15.067; P = 0.021), and followed by HPV 16 E-p variant while E-G350 variant only appeared in HSIL and cervical cancer.
Abstract: The HPV 16 variants were determined by sequencing parital E6 region and the detected variants were European prototype E-T350 (E-p), E-G350, E-C109 G, Asian (As) and Asian-American (AA), among which the E-p variant was the most prevalent (82.76%) followed by As variant.
Phylogeny and polymorphism in the E6 and E7 of human papillomavirus: alpha-9 (HPV16, 31, 33, 52, 58), alpha-5 (HPV51), alpha-6 (HPV53, 66), alpha-7 (HPV18, 39, 59, 68) and alpha-10 (HPV6, 44) in women from Shanghai.
Abstract: However, T7220G (D32E) variation in HPV16 E6 and A7689G (N29S) in HPV16 E7 increased the incidence of HSIL compared to the <HSIL group (P = 0.036 and 0.022).
Abstract: The A388C (K93 N) variation in HPV58 E6 can significantly reduce the risk of HSIL (P = 0.015).
Genetic variability in E5, E6, E7 and L1 genes of human papillomavirus type 31.
Abstract: T4053A (F80I), C285T (H60Y), C520T (A138V) and A743G (K62E) were the most common non-synonymous mutations.
Abstract: The most common non-synonymous mutations of L1 genes were A6350G (T29A) and C6372A (T36N).
Phylogenetic analysis of Human papillomavirus 16 variants isolated from Indian Breast cancer patients showed difference in genetic diversity with that of cervical cancer isolates.
Abstract: Besides the selection of some common variants in both BC and CACX, some unique variants in BC (D98Y; 395 G>T) and CACX (R48W; 245 G>T) were observed.
Abstract: The 7521 G>A variant of LCR showed association with Luminal B subtype of BC and progression of CACX.
Abstract: Whereas, 145 G>T (Q14H) and 335 C>T (H78Y) variants of <
Human Papillomavirus Replication Regulation by Acetylation of a Conserved Lysine in the E2 Protein.
Abstract: In contrast, the K111 glutamine (K111Q) mutant increased origin melting and stimulated replication compared to wild-type E2.
Abstract: While the replication-defective E2-K111R mutant recruited E1 to the viral replication origin, surprisingly, unwinding of the duplex DNA did not occur.
Identification and Functional Characterization of Phosphorylation Sites of the Human Papillomavirus 31 E8^E2 Protein.
Abstract: However, comparative transcriptome analyses of differentiated HPV31 E8^E2 S78A and S78E cell lines reveal that the expression of a small number of cellular genes is changed.
The polymorphisms of LCR, E6, and E7 of HPV-58 isolates in Yunnan, Southwest China.
Abstract: In the LCR, C7265G and C7266T were the most variable sites and were the potential binding sites for the transcription factor SOX10.
Abstract: Six non-synonymous amino acid substitutions (including S71F and K93 N in the E6, and T20I, G41R, G63S/D, and V77A in the E7) were affecting multiple putative epitopes for both CD4+ and CD8+ T-cells.
Abstract: The most common non-synonymous substitution V77A in the E7 was observed in the sequences encoding the alpha-helix.
Result: C307T
The HPV16 E1 Carboxyl Domain Provides a Helper Function for Adeno-Associated Virus Replication.
Abstract: METHODS: Rep78-E1 interaction was analyzed by Gal4-based yeast two-hybrid (Y2H)-cDNA assay.
Abstract: RESULTS: Gal4-Y2H- cDNA assay found in vivo Rep78-E1-binding activity across E1, but the carboxyl-third (amino acids [aa] 421-649) of E1 contained the predominant DNA replication helper domain.
HPV mutation literature information.
PMID: 
2019
International journal of medical sciences
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