Identification of human papillomavirus type 16 variants circulating in the Calabria region by sequencing and phylogenetic analysis of HPV16 from cervical smears.
PMID: 30578936
2019
Infection, genetics and evolution
Abstract: The most common SNP was the T350G (29/39 samples, 74.4%), causing the L83 V amino acid change in the E6.
Oncogenic comparison of human papillomavirus type 58 E7 variants.
PMID: 30575267
2019
Journal of cellular and molecular medicine
Abstract: Among them, the T20I/G63S variant (V1) had a stronger epidemiological association with cervical cancer.
Abstract: Previously, we identified the three most common circulating HPV58 E7 strains contained amino acid alterations: G41R/G63D (51%), T20I/G63S (22%) and T74A/D76E (14%) respectively.
Introduction: Concordant with our previous finding, the HPV58 E7 V1 (T20I/G63S) variant conferred a significantly higher risk for CIN III and PMID: 30471332
2019
Gene
Abstract: The sublineage A3 variants with T20I/G63S substitutions at E7 oncoprotein carried a significantly higher risk for high-grade cervical intraepithelial neoplasia (CIN2 or worse, CIN2+) when compared with other HPV58 variants (odds ratio = 4.41, P < 0.05).
Oncogenicitiy Comparison of Human Papillomavirus Type 52 E6 Variants.
PMID: 30676312
2019
The Journal of general virology
Abstract: In the present study, we compared the oncogenicity of E6 derived from the HPV-52 prototype and three commonly found variants, V1 (K93R), V2 (E14D/V92L) and V3 (K93R/N122K), through molecular and phenotypic approaches.
Phosphorylation of a Conserved Tyrosine in the Papillomavirus E2 Protein Regulates Brd4 Binding and Viral Replication.
Abstract: Interestingly, the Y138E protein coimmunoprecipitated with full-length Brd4 but was defective for association with its C-terminal domain (CTD).
Abstract: The tyrosine to glutamic acid (E) mutant Y138E, which can mimic phosphotyrosine, failed to induce transient DNA replication, although it maintained the ability to bind and localize the viral DNA helicase E1 to the viral origin.
Characterization of an HPV33 natural variant with enhanced transcriptional activity suggests a role for C/EBPbeta in the regulation of the viral early promoter.
Abstract: T7791C abrogated binding of recombinant C/EBPbeta to this site in vitro and stimulated the EP in vivo, suggesting that it abrogates a negatively-acting regulatory element.
Abstract: This increased promoter activity was ascribed to a single nucleotide variation in the LCR, T7791C, in a putative binding site for the transcription factor C/EBPbeta.
Introduction: In further support of this notion, we observed that the C7732G variation that is present in some A2-sublineage variants and which we previously found to be associated with high grade squamous intraepithelial lesion (HSIL), also increases the activity of the HPV33 EP approximately 2-fold in PHK.
Introduction: Our results indicate that the
Genetic variations in E6, E7 and the long control region of human papillomavirus type 16 among patients with cervical lesions in Xinjiang, China.
Abstract: Interestingly, the HPV8-E7L23A mutant, which cannot trigger keratinocyte invasion was unable to activate fibronectin gene expression.
Human Papillomavirus Type 16 E1 Mutations Associated with Cervical Cancer in a Han Chinese Population.
PMID: 31341418
2019
International journal of medical sciences
Abstract: In the sub-lineage analysis, the differences in the T933A (A23A), T1014G (D50E) and G2160A (R432R) mutations were statistically significant between the case and control groups for the A4 (As) sub-lineage (P<0.05), and the differences in the T2232C (F456F), G2337A (M491I) and A2547G (P561P) mutations were statistically significant between the case and control groups for the A1-A3 (EUR) sub-lineage (P<0.05).
Introduction: reported that the A1668G, G2073A, T21
Analysis of Nucleotide Alterations in the E6 Genomic Region of Human Papillomavirus Types 6 and 11 in Condyloma Acuminatum Samples from Brazil.
Abstract: In the analysis of the HPV11 samples, all patients showed the mutations T137C and (cytosine) C380T.
Abstract: One patient also presented the nucleotide alteration T410C.
Abstract: Twelve samples were identified as the HPV6B3 variant, presenting the mutation (guanine) G474A (adenine), and one of them also showed the mutation (thymine) T369G.
Result: After sequence analysis of the 25 HPV6 samples, it was noted that 12 (48%) samples belong to the HPV6B3 (L42216) variant and that all of these samples presented the G474A mutation compared to the prototype E6 sequence.
Result: Analysis of seven HPV11 samples revealed that all samples belong to the HPV11A2 variant but only the sample BR_CA28_A2 showed the nucleotide al
HPV mutation literature information.
PMID: 
2019
Infection, genetics and evolution
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