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 HPV mutation literature information.


  Phosphorylation of the Human Papillomavirus E2 Protein at Tyrosine 138 Regulates Episomal Replication.
 PMID: 32350070       2020       Journal of virology
Abstract: Here, we demonstrate that HPV-16 E2 Y138E bound to full-length Brd4 but not to the Brd4 CTM.
Abstract: In this study, we generated quasiviruses containing G418-selectable HPV-31 genomes with phosphodeficient phenylalanine mutant E2 Y138F and phosphomimetic glutamic acid mutant Y138E.
Abstract: Keratinocytes infected with Y138F quasiviruses formed stable colonies, and the genomes were maintained as episomes, while those infected with Y138E quasiviruses did not.


  Association of Human Papillomavirus Type 16 Long Control Region Variations with Cervical Cancer in a Han Chinese Population.
 PMID: 32308546       2020       International journal of medical sciences
Abstract: For the sub-lineage analysis, only C7873G variations were significantly different between the case and control groups in the A4 (As) variant (P=0.039).
Abstract: Moreover, a total of eleven variations (A7167G, A7173C, C7176T, C7200T, T7269C, C7286A, C7729A, C7763T, A7841G, G7867A and T24C) were significantly different between the case and control groups (P<0.05).
Introduction: For example, the T variation of the E6 gene T350G (L83V) persi


  HPV16 L1 diversity and its potential impact on the vaccination-induced immunity.
 PMID: 32304786       2020       Gene
Abstract: Overall, 4 mutations were frequently found in HPV16 sequences: T176N and N181T in EF loop; A266T in the FG loop and T353P/I/N HI loop.


  Human Papillomavirus 58 E7 T20I/G63S Variant Isolated from an East Asian Population Possesses High Oncogenicity.
 PMID: 31996427       2020       Journal of virology
Abstract: Our previous international epidemiological studies revealed that HPV58 carrying an E7 natural variant, T20I/G63S (designated V1), was associated with a higher risk of cervical cancer.
Abstract: Since V1 is more commonly found in eastern Asia, our report provides insight into the design of HPV screening assays and selection of components for HPV vaccines in this region.IMPORTANCE Epidemiological studies have revealed that a wild-type variant of HPV58 carrying an E7 variation, T20I/G63S (V1), is associated with a higher risk of cervical cancer.


  Characterization of major capsid protein (L1) variants of Human papillomavirus type 16 by cervical neoplastic status in Indian women: Phylogenetic and functional analysis.
 PMID: 31944308       2020       Journal of medical virology
Abstract: Sixty-one SNPs were detected in L1 genes resulting in 20 nonsynonymous amino acid substitutions of which N56T, N92T, L158F, V178G, N181I, K236T, K443Q, K454T, and K475R are reported in Indian isolates for the first time.
Abstract: The substitutions N181T, T353P, and T389S were significantly associated with high-grade cervical disease.
Abstract: These substitutions, when mapped on three-dimensional structure, revealed that 11 and 4 substitutions are part of exp


  A Phase II, Prospective, Randomized, Multicenter, Open-Label Study of GX-188E, an HPV DNA Vaccine, in Patients with Cervical Intraepithelial Neoplasia 3.
 PMID: 31727676       2020       Clinical cancer research
Abstract: The HPV sequence analysis revealed that the HPV type 16 E6/E7 variants D25E, V83L, and N29S were inversely associated with histopathologic regression at V8.


  Genetic variability and functional implication of HPV16 from cervical intraepithelial neoplasia in Shanghai women.
 PMID: 31670402       2020       Journal of medical virology
Abstract:
Abstract: 6329G>T, a potential binding site for TATA-binding protein, is the most common in LCR variants.
Abstract: Amino acid substitutions (D32N/E, E36Q, H85Y, and E120D in E6 and N29H/S and R77C in E7) were predicted to have an effect on conserved structural and functional residues, and five amino acid substitutions (H85Y, E36Q, I34L, and D32E in E6; R77C in E7) would potentially change the secondary structure.


  High Levels of Within-Host Variations of Human Papillomavirus 16 E1/E2 Genes in Invasive Cervical Cancer.
 PMID: 33324377       2020       Frontiers in microbiology
Abstract: Among the high-level variations found in ICC, six were located in the E1/E2 genes, and all of them were non-synonymous substitutions (Q142K, M207I, and L262V for E1; D153Y, R302T, and T357A for E2).
Abstract: In vitro functional analyses of these E1/E2 variants revealed that E1/M207I, E2/D153Y, and E2/R302


  Characterization of an HPV33 natural variant with enhanced transcriptional activity suggests a role for C/EBPbeta in the regulation of the viral early promoter.
 PMID: 30911096       2019       Scientific reports
Abstract: T7791C abrogated binding of recombinant C/EBPbeta to this site in vitro and stimulated the EP in vivo, suggesting that it abrogates a negatively-acting regulatory element.
Abstract: This increased promoter activity was ascribed to a single nucleotide variation in the LCR, T7791C, in a putative binding site for the transcription factor C/EBPbeta.
Introduction: In further support of this notion, we observed that the C7732G variation that is present in some A2-sublineage variants and which we previously found to be associated with high grade squamous intraepithelial lesion (HSIL), also increases the activity of the HPV33 EP approximately 2-fold in PHK.
Introduction: Our results indicate that the


  Oncogenicitiy Comparison of Human Papillomavirus Type 52 E6 Variants.
 PMID: 30676312       2019       The Journal of general virology
Abstract: In the present study, we compared the oncogenicity of E6 derived from the HPV-52 prototype and three commonly found variants, V1 (K93R), V2 (E14D/V92L) and V3 (K93R/N122K), through molecular and phenotypic approaches.



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