Virusliterature

HPV mutation literature information.

The human papillomavirus type 16 E6 oncoprotein can down-regulate p53 activity by targeting the transcriptional coactivator CBP/p300.

PMID: 10400710 1999 Journal of virology

Abstract: An HPV-16 E6 mutant (L50G) that binds CBP/p300, but not E6AP, is still capable of down-regulating p53 transcriptional activity.

Human Papillomavirus 58 E7 T20I/G63S Variant Isolated from an East Asian Population Possesses High Oncogenicity.

PMID: 10475384 1999 Diagnostic molecular pathology

Abstract: A DNA sequence analysis of the PCR products revealed the conversion of Leu to Val in codon 83 of the E6 gene, correlating to the divergent band pattern.

Abstract: The purpose of the present investigation is to describe a rapid method for the detection of this variant HPV 16, E6 (L83V).

Abstract: This HPV 16 variant possesses a common mutation (T to G) in nucleotide 350 (codon 83) of the E6 gene, resulting in an amino acid shift, L83V, in the E6 protein.

Human papillomavirus type 16 E6 variants in cervical carcinoma: relationship to host genetic factors and clinical parameters.

PMID: 10567656 1999 The Journal of general virology

Abstract: The most common variation detected was a T to G transition at base pair 350, resulting in an amino acid change from a leucine to a valine.

A fifteen-amino-acid peptide inhibits human papillomavirus E1-E2 interaction and human papillomavirus DNA replication in vitro.

PMID: 9733858 1998 Journal of virology

Abstract: Mutation of the conserved glutamic acid residue at position 39 of human papillomavirus type 16 (HPV-16) E2 to alanine (E39A) disrupts its E1 interaction activity and its replication function in transient replication assays but does not affect E2 transcriptional activation.

Abstract: This E39A mutation also disrupts replication activity of HPV-16 E2 in HPV-16 in vitro DNA replication.

Two classes of human papillomavirus type 16 E1 mutants suggest pleiotropic conformational constraints affecting E1 multimerization, E2 interaction, and interaction with cellular proteins.

PMID: 9223484 1997 Journal of virology

Abstract: One class, represented by the S330R replication-defective mutant (containing an S-to-R change at position 330), remained competent for all protein-protein interactions tested, with the exception of hUBC9 association.

Major sequence variants in E7 gene of human papillomavirus type 16 from cervical cancerous and noncancerous lesions of Korean women.

PMID: 9264576 1997 Gynecologic oncology

Abstract: One had a single nucleotide change at position 666 (G --> A) and the other had one silent mutation at position 796 (T --> C).

Abstract: The second most common variant, found in 16.7% of cases, had three silent mutations at positions 732 (T --> C), 789 (T --> C), and 795 (T --> G).

Abstract: The variant with a single nucleotide change at position 647 (A --> G, Asn --> Ser) was found in about 60% of DNA samples with HPV 16.

Targeted mutagenesis of the human papillomavirus type 16 E2 transactivation domain reveals separable transcriptional activation and DNA replication functions.

PMID: 8627680 1996 Journal of virology

Abstract: The 173A mutant was defective for the transcriptional activation function but retained wild-type DNA replication activity, whereas the E39A mutant wild-type transcriptional activation function but was defective in transient DNA replication assays.

Abstract: The E39A mutant was also defective for HPV16 E1 binding in vitro, suggesting that the ability of E2 protein to form a complex with E1 appears to be essential for its function as an auxiliary replication factor.

Serum- and calcium-induced differentiation of human keratinocytes is inhibited by the E6 oncoprotein of human papillomavirus type 16.

PMID: 8627810 1996 Journal of virology

Abstract: To genetically map the HPV gene(s) responsible for this cellular phenotype, we cloned cDNAs for full-length E6, full-length E7, four truncated E6 splice variants (E6I to E6IV), and a series of E6 C-terminal truncation mutants into a simian virus 40 expression vector.

Human Papillomavirus 58 E7 T20I/G63S Variant Isolated from an East Asian Population Possesses High Oncogenicity.

PMID: 8806176 1996 Virus research

Abstract: E6I-III, in reticulocyte lysate (RTL).

Abstract: In wheat germ extract, in vitro translation resulted in the production of all five proteins, E6 and E6I-E6IV.

Abstract: The E6 variants E6I-E6IV, although able to associate with p53 at a low efficiency, were unable to target its degradation.

Abstract: These have the coding capacity for either the full length E6 of 151 amino acids (aa) or four truncated variants, E6I-E6IV, of 43-64 aa.

Polymorphism of the hpv-16 e6 gene of cervical-carcinoma.

PMID: 21552834 1995 International journal of oncology

Abstract: Nine DNA samples had heterozygous mutations within the same region of the E6 gene 3' terminus; T to C transitions at HPV-16 position 511 (silent) and one of the nine also had a 513 mutation (Met to Thr).

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