Virusliterature

HPV mutation literature information.

HPV16 E6 gene polymorphisms and the functions of the mutation site in cervical cancer among Uygur ethnic and Han nationality women in Xinjiang, China.

PMID: 35193568 2022 Cancer cell international

Discussion: In addition, there were 17 cases of E6<

Discussion: Our study found seven HPV16 E6 T295G and T350G nucleotide co-mutations, which may serve as a variant of the HPV16 European mutant strain.

Discussion: Studies have shown that HPV16 E6-T350G mutations in Moroccan women are prevalent in high-grade cervical lesions and are closely related to the progression of cervical cancer.

Discussion: There were 65 cases of E6 gene mutations at 350 nucleotides (T350G) with a mutation frequency of 63.64%, and corresponding amino acid change of leucine valine (L83V).

Prevalence and distribution of human papillomavirus (HPV) in Luoyang city of Henan province during 2015-2021 and the genetic variability of HPV16 and 52.

PMID: 35246180 2022 Virology journal

Abstract: For HPV16, The most prevalent mutations were T266A (27/27) and N181T (7/27) for L1, D32E for E6 and S63F for E7 in HPV16.

Abstract: For HPV52, all of the nucleotide changes were synonymous mutation in L1 (except L5S) and E7 genes.

Abstract: The K93R mutation was observed in most HPV52 E6 protein.

Result: All of the changes in HPV52 L1 gene were synonymous mutation except L5S (6.7%, 1/15).

Worldwide genetic variations in high-risk human papillomaviruses capsid L1 gene and their impact on vaccine efficiency.

PMID: 33636291 2021 Gene

Abstract: Four mutations were frequently observed in HPV16 L1 sequences: T353P in the HI loop, H228D in the EF loop, T266A in the FG loop, and T292A in the FG loop.

Abstract: Three mutations in HPV33 L1 sequences: T56N in the BC loop, G133S in the DE loop, T266K in the FG loop.

Abstract: Two mutations in HPV58 L1 sequences: T375N in the HI loop and L150F in the DE loop.

Human Papillomavirus E7 Oncoprotein Promotes Proliferation and Migration through the Transcription Factor E2F1 in Cervical Cancer Cells.

PMID: 33155930 2021 Anti-cancer agents in medicinal chemistry

Abstract: CONCLUSION: The HPV58 E7 T20I variant did not promote malignant behaviors compared with wild-type HPV58 E7.

Abstract: However, the HPV58 E7 T20I variant did not promote malignant behaviors compared with wildtype HPV58 E7.

Abstract: OBJECTIVE: This study aimed to determine whether the HPV58 E7 T20I (C632T) variant promotes the malignant behavior of cervical cancer cells and the underlying mechanism of the HR-HPV E7 oncoprotein involved in the development of cervical cancer.

Genetic variation of E6 and E7 genes of human papillomavirus 52 from Central China.

PMID: 33230866 2021 Journal of medical virology

Abstract: The nonconservative substitutions, such as K93R, K93E in E6, T37I, and D38N in E7, affected multiple hypothetical epitopes in the B cell.

The genetic variability, phylogeny and functional significance of E6, E7 and LCR in human papillomavirus type 52 isolates in Sichuan, China.

PMID: 33941222 2021 Virology journal

Abstract: 8 non-synonymous amino acid substitutions (including E3Q and K93R in the E6, and T37I, S52D, Y59D, H61Y, D64N and L99R in the E7) were potential affecting multiple putative epitopes for both CD4+ and CD8+ T-cells and B-cells.

Abstract: A7168G was the most variable site (100%) and the binding sites for transcription factor VAX1 in LCR.

Result: A378C and A379G together led to the amino acid substitution of K93R.

Result:

AutoVEM2: A flexible automated tool to analyze candidate key mutations and epidemic trends for virus.

PMID: 34512928 2021 Computational and structural biotechnology journal

Result: Among them, 8 specific mutations were missense mutation, including 83L>V (T350G) on the E6 gene, 219P>S (C3409T) on the E2 gene, 39I>L (A3977C) and 60I>V (A4040G) on the E5 gene, 43E>D (A4363T) and 330L>F (A5224C) on the L2 gene, 228H>D (C6240G) and 292 T>A (A6432G) on the

Association of cervical carcinogenesis risk with HPV16 E6 and E7 variants in the Taizhou area, China.

PMID: 34217247 2021 BMC cancer

Abstract: Furthermore, nucleotide variation in HPV16 E6 T178G is associated with the development of cervical cancer.

Discussion: Additionally, HPV16 E6 H85Y and E120D belong to the A2 sublineage in this study but are not associated with cervical cancer.

Discussion: In our study, we did not find that HPV16 E6 T350G (L90V) was associated with cervical cancer risk, which is in good agreement with previous data in China.

Discussion: In particular, we found that the three most common variations in HPV16 isolates were the

PMID: 34089910 2021 Infection, genetics and evolution

Abstract: Both unique patterns partly restored the LCR activating potential disrupted by K308R.

Abstract: In the E2, the ubiquitous polymorphism K308R caused stronger binding between the dimers but did not alter DNA binding; E2s with this polymorphism were significantly less efficient than the reference in promoting LCR activity.

Abstract: The unique polymorphism Q86K changed the negative surface charge of E2 (Q86) to positive (K86).

Abstract: The unique polymorphisms S245F and N247T in the hinge region disrupt a probable phosphorylation site in a RXXS motif targeted by protein kinase A and B, but do not affect directly the

Modeling and Molecular Dynamics of the 3D Structure of the HPV16 E7 Protein and Its Variants.

PMID: 33573298 2021 International journal of molecular sciences

Result: H51N Loses beta-Sheets throughout the Trajectory Simulation.

Result: After obtaining the E7 model, we generated the variants with their respective mutations N29S (orange) and H51N (blue) in PyMOL, as seen in Figure 1C.

Result: Figure 1A shows that the changes in the N29S variant (blue) were located inside the CR2 region, and those of the H51N variant (orange) were in the CR3 region.

Result: However, Figure 4B indicates that most of the secondary structures of N29S were preserved.

Browser Board

Co-occurred Entities

Filtrator