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 HPV mutation literature information.


  Detection and expression of human papillomavirus oncogenes in non-small cell lung cancer.
 PMID: 16786144       2006       Oncology reports
Abstract: Sequencing of the entire E6 and E7 genes of HPV16 showed a T to G transition at nucleotide position 350 of E6, in all examined cases.


  The human papillomavirus type 16 E7 protein binds human interferon regulatory factor-9 via a novel PEST domain required for transformation.
 PMID: 16800784       2006       Journal of interferon & cytokine research
Abstract: Finally, we used alanine-scanning mutagenesis to determine if E7-IRF-9 interaction was important for E7-mediated cellular transformation and found that the HPV-16 E7 mutants Y25A, E26A, S31A, S32A, and E35A, but not L28A and N29A, caused loss of transformation ability.


  A deletion and point mutation study of the human papillomavirus type 16 major capsid gene.
 PMID: 16938363       2006       Virus research
Abstract: Binding of Mab H16:E70 to A266T was reduced by almost half in comparison to wild type L1.
Abstract: Retention of the C-terminal region 428-483 was critical for the binding of conformation-specific Mabs (H16:V5, H16:E70, H16:U4 and H16:9A) whereas deletion of the nuclear localisation signal (NLS) or the C428G mutation or an N-terminal deletion (residues 2-9) did not affect the antigenicity.
Abstract: The N-terminal deletion resulted in a mixed population of 30 and 55nm VLPs, which differs from the same construct expressed in Escherichia coli, whereas pentamer aggregates resulted from deletion of the 428-465 region or the C428G mutation.
Abstract: This paper analyses, using a panel of well-characterised Mabs, the effects on the antigenicity of various C- and N-terminal deletants of HPV-16 L1 m


  Human papillomavirus type 33 polymorphisms and high-grade squamous intraepithelial lesions of the uterine cervix.
 PMID: 16960775       2006       The Journal of infectious diseases
Abstract: The C7732G variation, which results in the loss of a putative binding site for the cellular upstream stimulatory factor, was associated with HSILs (age- and site-adjusted OR, 8.0 [95% CI, 1.5-42.8]).
Abstract: The HPV-33 MT 1-0-0 variant carrying the G7584A variation was detected more frequently in women from Brazil (7/20 [35%]) than in women from Canada (1/65 [1.5%]; P=.001).


  Human papillomavirus typing of invasive cervical cancers in Italy.
 PMID: 17192187       2006       Infectious agents and cancer
Abstract: Of the 32 HPV 16 positive cases, sequencing of the E6 gene could be performed in 25; the prototype isolate was identified in 7, and the variant T350G in 18; in 4 cases one or more additional mutations were present.
Result: Interestingly, the A257G mutation has been firstly described very recently, and occurred in combination with the T350G variant, as in our case.
Result: Of the naturally occurring HPV 16 viral variants, the T350G (L83V) is the most commonly found among invasive cancers, and has been linked to an increased risk for cervical disease progression.
Result: Sequence analysis of the E6 gene in 25 HPV 16 positive ICC<


  The prevalence of HPV-18 and variants of E6 gene isolated from cervical cancer patients in Taiwan.
 PMID: 15572004       2005       Journal of clinical virology
Abstract: The identified HPV-18 E6 variants had a unique silence mutation located on C183G in E6 coding region.
Abstract: The most dominant mutation among 25 tested patients was a silence mutation C183G of the E6 coding region.


  Polymorphism in the E6 gene of human papillomavirus type 16 in the cervical tissues of Korean women.
 PMID: 15670304       2005       International journal of gynecological cancer
Abstract: No significance difference was found between the frequencies of D25E variation in cancerous and non-cancerous lesions.
Abstract: The most frequently found variation was D25E (in NCD, n = 8, 80%; in CIN, n = 9, 52.9%; in ICC, n = 23, 85.2%).


  Human papillomavirus type 16 E2 and E6/E7 variants.
 PMID: 15721413       2005       Gynecologic oncology
Abstract: RESULTS: In the 100 samples analyzed, only one new polymorphism was identified, a synonymous change, T3205A, in region E2.
Abstract: The frequency distribution of variants in the sample set was 37 European prototypes and 27 E-G350, 16 AA, 5 Af1, 2 Af2, 8 E-C109G, 3 E-G131G, and 2 As.


  Human papillomavirus type 16 E1 E4-induced G2 arrest is associated with cytoplasmic retention of active Cdk1/cyclin B1 complexes.
 PMID: 15767402       2005       Journal of virology
Abstract: A mutant 16E1 E4 (T22A, T23A) which does not bind cyclin B1 or alter its intracellular location fails to induce G2 arrest.


  Interaction of host and viral risk factors for development of cervical carcinoma in situ.
 PMID: 15929080       2005       International journal of cancer
Abstract: However, an association was found between the HPV 16 E6 L83V variant and the DR*04-DQ*03 haplotype.



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