Abstract: Viral variant L83V was present in 3/4 HPV 16 positive recurrent cases.
Human papillomavirus type 16 E6 gene variations in Chinese population.
PMID: 19699050
2010
European journal of surgical oncology
Abstract: CONCLUSION: The D25 E variant is the most prevalent E6 genomic variant in Hubei, China.
Abstract: The rank orders of incidence of HPV 16 prototype and E6 variants were as follows: D25E (62%), the prototype (17%), E113D (9%), L83V (6%) in case subjects; the prototype (71%), D25E (23%), L83V/E113D (7%) in control subjects.
Destabilization of Rb by human papillomavirus E7 is cell cycle dependent: E2-25K is involved in the proteolysis.
Abstract: An in vivo analysis using multiple catalytic site mutant dominant negative E2 enzymes show that the C92A E2-25K most effectively blocks E7-induced Rb proteolysis.
Result: C92A E2-25K also extended the half-life of E7 in the transfected cells, suggesting that E7 and Rb proteolysis are linked in th
Result: Among the other tested E2 mutants, C85A UbcH5A showed detectable increase in the level of Rb.
Result: As shown in Figure 5C, C92A E2-25K increased the half-life of E7 in absence of a functional Rb.
The immortalizing and transforming ability of two common human papillomavirus 16 E6 variants with different prevalences in cervical cancer.
Abstract: A total of 8 hot mutation spot was identi-fied, which were URR G7521A (100%), C7435G (96.77%), C24T (45.16%), A7729C (45.16%), G7839A (45.16%), E6 T178G (41.94%), E7 A647G (45.16%), and T846C (45.16%).
Abstract: Our results suggested that the mutations of G7521A, A7729C, G7839A, T178G, T350G, A647G, and G658A were likely to be a
[The enhancement of DNA binding ability of a mutated E2 (A338V) protein of HPV-2].
Abstract: Previously we reported that the repression of a mutated E2 protein of HPV-2 isolated from a patient with huge common wart on the viral early promoter was obviously decreased, and A338V mutation located at the C terminal DNA binding region of E2 protein.
Distribution of human papillomavirus 58 and 52 E6/E7 variants in cervical neoplasia in Chinese women.
Abstract: CONCLUSIONS: These findings suggest that C632T (T20I) and G760A (G63S) variants in HPV58 E7 are probably risk factors associated with the development of cervical cancer in Chinese women.
Abstract: For HPV58, the presence of C632T (T20I) and G760A (G63S) variants in E7 showed a positive trend of the association with the severity of neoplasia (P(trend)<0.05, chi2 test for trend).
Distribution of human papillomavirus 16 E6/E7 variants in cervical cancer and intraepithelial neoplasia in Chinese women.
PMID: 21051983
2010
International journal of gynecological cancer
Abstract: In addition, 3 novel variants at E6 (Q20P, H118Q, and Q123K) and 2 at E7 (D75N and T86P) were found.
Abstract: The substitution G368T at E6 leading to a premature stop codon occurred in an isolate of normal control sample.
HPV-16 E6 L83V variant in squamous cell carcinomas of the upper aerodigestive tract.
PMID: 18841393
2009
Journal of cancer research and clinical oncology
Abstract: The HPV-16 E6 L83V variant was present in five cases.
Abstract: The potential prognostic significance of HPV-16 E6 L83V variant in HPV-16 positive UADT-SCCs should be more extensively investigated.
HPV mutation literature information.
PMID: 
2010
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