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 HPV mutation literature information.


  Genomic polymorphism of human papillomavirus type 52 in women from Northeast China.
 PMID: 23203106       2012       International journal of molecular sciences
Discussion: Among HPV 52 isolates, the LCR T7624G/C substitution was detected in all of the samples tested.
Discussion: Among the four mutations, only A379G (K93R) was nonsynonymous.
Discussion: Except for C6917A, all the other mutations in the HPV 52 L1 gene were not described elsewhere.
Discussion: In accordance with Xin's report, the unique A379G (K93R) variation was located in the strand H1 and the third predicted zinc finger of E6 protein and occurred in almost all of the HPV 52 positive samples.


  Expression of human papillomavirus type 16 E7 is sufficient to significantly increase expression of angiogenic factors but is not sufficient to induce endothelial cell migration.
 PMID: 21159359       2011       Virology
Abstract: Conditioned media from HFKs expressing the HPV 16 E6 and the E7 mutant E7C24G, which can target p107 and p130 but not pRb for degradation, contained increased levels of VEGF and IL-8.
Result: Although the HPV 16 E7C24G mutant has been reported to retain the ability to target another pRb family member, p107, for degradation, the ability of this mutant to target p130 for degradation has not been reported.
Result: By changing the cysteine at amino acid 24 to a glycine (C24G), HPV 16 E7 loses affinity for pRb and the ability to target pRb for degradation.
Result: In contrast, VEGF expression was increased 8.7-fold (p< 0.0001) in cells expressing HPV 16E6E7


  The E2 protein of human papillomavirus type 8 increases the expression of matrix metalloproteinase-9 in human keratinocytes and organotypic skin cultures.
 PMID: 21274725       2011       Medical microbiology and immunology
Abstract: An E2 transactivation-defective mutant (I73L) as well as a DNA-binding deficient mutant (R433K) demonstrated no activation of the MMP9 promoter, suggesting that both an intact transactivation and DNA-binding domain are required for E2 activation of the MMP9-promoter.


  Genetic diversity of HPV-16 E6, E7, and L1 genes in women with cervical lesions in Liaoning Province, China.
 PMID: 21436703       2011       International journal of gynecological cancer
Abstract: Sequences of the E6 gene revealed 4 amino acid changes of variants D25E and L83V, with 48.3% (69/143) and 11.2% (16/143), respectively, and variants H78Y and E113D in this study.
Abstract: The following L1 variations were found in this study: L103F, P104K, P104Y, P104S, D105G, P106S, N108P, F109V, C172S, H228D, and T292A.
Abstract: The results also showed the prevalence of 4 hot


  Human papillomavirus type 16 variant analysis of E6, E7, and L1 [corrected] genes and long control region in [corrected] cervical carcinomas in patients in northeast China.
 PMID: 21593270       2011       Journal of clinical microbiology
Abstract: The most frequently observed variation sites were T178G (32.69%) in E6; A647G (34.62%), G666A (38.46%), and T846C (32.69%) in E7; C6826T (36.17%) and G7060A (61.70%) in L1; and G7521A (98.08%) in the LCR.
Abstract: The most prevalent amino acid variations were D25E in E6 and N29S in E7.


  Rare human papillomavirus 16 E6 variants reveal significant oncogenic potential.
 PMID: 21702904       2011       Molecular cancer
Abstract: R8Q induced a unique phenotype characterized by thin organotypic raft cultures, low expression of keratin 10, and high expression of keratins 5 and 14 throughout all raft layers.
Abstract: Interestingly, in a reporter based assay R8Q exhibited a higher ability to augment TCF/beta-catenin transcription.
Abstract: Like L83V, raft cultures derived from variants R10G and R48W similarly induced hyperplasia and aberrantly expressed keratin 5 in the suprabasal compartment with significantly lower expression of keratin 10.
Abstract: Unlike L83V, both variants, and particularly R48W, induced increased levels of anoikis upon suspension in semisolid medium.


  Human papillomavirus type 16 E6 inhibits p21(WAF1) transcription independently of p53 by inactivating p150(Sal2).
 PMID: 21791360       2011       Virology
Abstract: A HPV16 E6 mutant, L110Q, which was unable to bind p150(Sal2), did not affect the ability of the cellular protein to bind p21(WAF1) promoter, underlining the linkage between these events.


  Gene expression profiles are altered in human papillomavirus-16 E6 D25E-expressing cell lines.
 PMID: 21943319       2011       Virology journal
Abstract: Previously, we have reported that the human papillomavirus (HPV) type 16 E6 D25E is the most prevalent variant in Korean women at high risk for cervical cancers.
Abstract: These results further emphasize the unique biological activity of the HPV-16 E6 D25E variant.
Abstract: To investigate whether the HPV-16 E6 D25E variant might influence cervical cancer progression, we used an oligonucleotide microarray approach to identify transcriptionally altered gene expression patterns in recombinant wild-type E6 or E6 D25E variant-expressing HPV-nega


  An in vitro multistep carcinogenesis model for both HPV-positive and -negative human oral squamous cell carcinomas.
 PMID: 22016834       2011       American journal of cancer research
Abstract: To elucidate underlying processes, we transduced either HPV16 E6/E7 or mutant CDK4 (CDK4(R24C)), cyclin D1 and human telomerase reverse transcriptase (TERT) into primary human tongue keratinocytes (HTK), and obtained immortal cell populations, HTK-16E6E7 and HTK-K4DT.


  Prevalence of HPV 16 genomic variant carrying a 63 bp duplicated sequence within the E1 gene in Slovenian women.
 PMID: 22131113       2011       Acta dermatovenerologica Alpina, Pannonica, et Adriatica
Abstract: Recently, a novel, presumably less pathogenic, HPV-16 E6-T350G genomic variant has been identified, carrying a 63-bp in-frame insertion in the E1 gene.



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