Transactivation activity of human papillomavirus type 16 E6*I on aldo-keto reductase genes enhances chemoresistance in cervical cancer cells.
PMID: 22278827
2012
The Journal of general virology
Abstract: Site-directed mutagenesis of 16E6*I revealed that transactivation activity was abolished in R8A, R10A and T17A 16E6*I mutants without altering their intracellular localization patterns.
A point mutation in the DNA-binding domain of HPV-2 E2 protein increases its DNA-binding capacity and reverses its transcriptional regulatory activity on the viral early promoter.
Abstract: CONCLUSIONS: These results suggest that the mutation from Ala to Val at aa 338 is critical for E2 DNA-binding and its transcriptional regulation.
Abstract: Electrophoresis mobility shift assays (EMSA) showed that the binding affinity of E2 protein with A338V mutation to both an artificial probe with two E2 binding sites or HPV-2 and HPV-16 promoter-proximal LCR sequences were significantly stronger than that of the HPV-2 prototype E2.
Abstract: Furthermore, co-expression of the construct containing A338V mutant exhibited increased activities on heterologous HPV-16 early promoter P97 than that of prototype E2.
Abstract: Previously we reported a HPV-2
Whole genome analysis of human papillomavirus type 16 multiple infection in cervical cancer patients.
PMID: 22524831
2012
Asian Pacific journal of cancer prevention
Abstract: An amino acid variation N29S within the E7 oncoprotein significantly associated with severity of lesion was also discovered.
Abstract: HPV16 European variant prone to single infection may harbor a major variation at L83V which significantly increases the risk for developing cervical carcinoma.
Abstract: In the E6 region, amino acid changes at L83V were related to increased cancer progression.
Human papillomavirus (HPV) 16 E6 variants in tonsillar cancer in comparison to those in cervical cancer in Stockholm, Sweden.
Abstract: CONCLUSION: The relatively high frequency of the R10G variant in TSCC, as compared to what has been found in CC both in the present study as well as in several other studies in different countries, may indicate a difference between TSCC and CC with regard to tumor induction and development.
Abstract: RESULTS: The rare E6 variant R10G was relatively frequent (19%) in TSCC, absent in CC and infrequent (4%) in CS, while the well-known L83V variant was common in PMID: 22571619
2012
Cell & bioscience
Abstr
Introduction: The first amino acid substitution (T20I) is close to the Leu-Xaa-Cys-Xaa-Glu domain that mediates association with the retinoblastoma protein (pRb) and its related proteins, p107 and p130.
Introduction: The substitution G63S results in a serine which could be phosphorylated by casein kinase II, and a positive association between phosphorylation rate and oncogenic potential of E7 has been reported.
Introduction: This variant harboring two amino acid substitutions, T20I and G63S, in the E7 protein was found to associate with an odds ratio of 10.14 (95% confidence interval = 10.14-74.72) for the development of cervical cancer, which was 6.9-fold higher than HPV58 variants without these sequence variations.
Whole genome sequencing and evolutionary analysis of human papillomavirus type 16 in central China.
Abstract: Bayesian analysis identified several important amino acid positions that may be driving adaptive selection in the HPV 16 population, including R10G, D25E, L83V, and E113D in the E6 gene.
Table: D25E
Table: L83V
Table: N29S
Discussion: A previous study found that L83V appears to enhance MAPK signaling and L83V is involved in oncogenic Ras-mediated transformation, efficient degradation of Bax and binding to E6BP and decreased binding to human discs large protein (hDlg).
Discussion: For example, E2 T310K has been linked to high grad
Variant lineages of human papillomavirus type 18 in Northeast China populations characterized by sequence analysis of E6, E7, and L1 regions.
PMID: 22622951
2012
International journal of gynecological cancer
Abstract: All the L1 genes of the analyzed HPV 18 strains had 4 C-G transversions at nucleotide positions of 5701, 6460, 6625, and 6842 and one G-A transition at position 5503.
Abstract: Moreover, strains with L1 nucleotide variations of A5920T, A6431T, and G6987A leading to amino acid substitutions of A164V, Q334P/H, and D520N are novel variants.
Abstract: Strains with variations of C287G, T482C, and C519A in E6 and C751T in E7 were novel variant
Variations of human papillomavirus type 58 E6, E7, L1 genes and long control region in strains from women with cervical lesions in Liaoning province, China.
PMID: 22659102
2012
Infection, genetics and evolution
Abstract: Among them, the A140G (T11A), A184C (E25D), G266C (V53L) and A313G were novel variations.
Abstract: Sequencing of the E7 gene revealed four typical nucleotide changes: G761A (G63D), G694A (G41R), T803C (V77A) and T744G.
Abstract: The most frequently observed variations were C307T (52.4%) in E6, T744G (74.9%) in E7
Molecular and phylogenetic analysis of the HPV 16 E4 gene in cervical lesions from women in Greece.
Abstract: In addition, nine amino acid mutations (A7V, A7P, L16I, D45E, L59I, L59T, Q66P, S72F, H75Q) were detected in the E1( )E4 protein, and these were associated with the severity of cervical malignancy.
Characterization and whole genome analysis of human papillomavirus type 16 e1-1374^63nt variants.
Abstract: Furthermore, it appears that the silent variation 109T>C of the E-C109/G350 variant might have a significant role in the viral life cycle and warrants further study.
Abstract: However, this study shows that the variations within the E1 region could possibly affect cervical disease, since the E1-1374^63nt E-G350 variant is significantly associated with lower grade cervical lesions, in comparison to the A1 and A2 sub-lineage variants.
Abstract: In comparison to the referent HPV16, the E1-1374^63nt E-G350 variant was significantly associated with lower grade cervical lesions
HPV mutation literature information.
PMID: 
2012
The Journal of general virology
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