Abstract: Recent experiments demonstrated that three E6 single-site mutants (F47R, R102A, and L50E) can inhibit the E6/E6AP/p53 heterotrimer formation and rescue p53 from the degradation pathway.
Investigation of the diversity of human papillomavirus 16 variants and L1 antigenic regions relevant for the prevention of human papillomavirus-related oropharyngeal cancer in Japan.
Abstract: The only nonsynonymous substitution detected in the L1 antigen loop region was p.N181T in the EF loop, which was found in 28/70 (40%) cases.
Human Papillomavirus E7 Oncoprotein Promotes Proliferation and Migration through the Transcription Factor E2F1 in Cervical Cancer Cells.
PMID: 33155930
2021
Anti-cancer agents in medicinal chemistry
Abstract: CONCLUSION: The HPV58 E7 T20I variant did not promote malignant behaviors compared with wild-type HPV58 E7.
Abstract: However, the HPV58 E7 T20I variant did not promote malignant behaviors compared with wildtype HPV58 E7.
Abstract: OBJECTIVE: This study aimed to determine whether the HPV58 E7 T20I (C632T) variant promotes the malignant behavior of cervical cancer cells and the underlying mechanism of the HR-HPV E7 oncoprotein involved in the development of cervical cancer.
Genetic variation of E6 and E7 genes of human papillomavirus 52 from Central China.
Abstract: The nonconservative substitutions, such as K93R, K93E in E6, T37I, and D38N in E7, affected multiple hypothetical epitopes in the B cell.
Modeling and Molecular Dynamics of the 3D Structure of the HPV16 E7 Protein and Its Variants.
PMID: 33573298
2021
International journal of molecular sciences
Abstract: An analysis of the structural differences of the HPV16 E7 protein and its variants (N29S and H51N) was performed through homology modeling and structural refinement by molecular dynamics simulation.
Abstract: Epidemiological studies have proposed that the presence of the N29S and H51N variants of the HPV16 E7 protein is significantly associated with cervical cancer.
Abstract: We propose, for the first time, a 3D structure of the E7 reference protein and two of Its variants (N29S and H51N), and conclude that the mutations induced by the variants in N29S and PMID: 33636291
2021
Gene
Abstract: Four mutations were frequently observed in HPV16 L1 sequences: T353P in the HI loop, H228D in the EF loop, T266A in the FG loop, and T292A in the FG loop.
Abstract: Three mutations in HPV33 L1 sequences: T56N in the BC loop, G133S in the DE loop, T266K in the FG loop.
Abstract: Two mutations in HPV58 L1 sequences: T375N in the HI loop and L150F in the DE loop.
Sequence variation analysis of the E1 and E2 genes of human papillomavirus type 16 in cervical lesions in women from the south of Poland.
Abstract: 8 non-synonymous amino acid substitutions (including E3Q and K93R in the E6, and T37I, S52D, Y59D, H61Y, D64N and L99R in the E7) were potential affecting multiple putative epitopes for both CD4+ and CD8+ T-cells and B-cells.
Abstract: A7168G was the most variable site (100%) and the binding sites for transcription factor VAX1 in LCR.
Result: A378C and A379G together led to the amino acid substitution of K93R.
Result:
Effect of E2 and long control region polymorphisms on disease severity in human papillomavirus type 11 mediated mucosal disease: Protein modelling and functional analysis.
PMID: 34089910
2021
Infection, genetics and evolution
Abstract: Both unique patterns partly restored the LCR activating potential disrupted by K308R.
Abstract: In the E2, the ubiquitous polymorphism K308R caused stronger binding between the dimers but did not alter DNA binding; E2s with this polymorphism were significantly less efficient than the reference in promoting LCR activity.
Abstract: The unique polymorphism Q86K changed the negative surface charge of E2 (Q86) to positive (K86).
Abstract: The unique polymorphisms S245F and N247T in the hinge region disrupt a probable phosphorylation site in a RXXS motif targeted by protein kinase A and B, but do not affect directly the
Association of cervical carcinogenesis risk with HPV16 E6 and E7 variants in the Taizhou area, China.
Abstract: Furthermore, nucleotide variation in HPV16 E6 T178G is associated with the development of cervical cancer.
Result: A subset of the A2 sublineage appeared to be uniquely defined by the C335T (H85Y) and A442C (E120D) in E6 and A646C (N29H) in E7, and a subset of the A1 sublineage was uniquely defined by the C790T (R77C) in the E7 gene.
Result: Additionally, the substitution G823T at E7 leading to
HPV mutation literature information.
PMID: 
2022
Biophysical journal
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