Investigation of the diversity of human papillomavirus 16 variants and L1 antigenic regions relevant for the prevention of human papillomavirus-related oropharyngeal cancer in Japan.
Abstract: N133S non-synonymous mutations of HPV 68 E6 and C67G, T68 A/M of HPV68 E7 are E6, E7 positive selection sites, they all located in the key domains and major motifs of E6/E7 protein, the above amino-acid substitutions changed the protein structure, disturbed the interaction with other protein or cellular factors and make a difference in epitopes affinity, may affect the pathogenicity and adaptability of HPV68 to the environment.
Predominance of genomically defined A lineage of HPV16 over D lineage in Indian patients from eastern India with squamous cell carcinoma of the cervix in association with distinct oncogenic phenotypes.
Result: Additionally, 4 variants had significantly higher frequencies among non-malignant specimens [E1 (G1363A; G167S), L2 (A5063C; N276T), L2 (A5492C; I418T), and L1 (A6434G; T266A)].
Result: All such deleterious variants were rare (frequency < 0.05), except for the E2/E4 variant A3366C.
Result: Among the lineages and sublineages of HPV16 thus identified, additionally a total of 35 bi-allelic variants were found capable of distinguishing lineages A a
Genetic variation of E6, E7, and L1 genes of human papillomavirus 51 from central China.
Abstract: Among which, 250 cases HPV-16 E6, 96 cases HPV-31 E6, 216 cases HPV-33 E6, 288 cases HPV-52 E6 and 405 cases HPV-58 E6 were successfully amplified, 17, 6, 6, 13, and 4 non-synonymous nucleotide mutations were respectively detected in HPV-16, 31, 33, 52, and 58 E6, 7 positive selection sites of alpha-9 HPV E6 were selected out (D32E of HPV-16 E6, K35N, K93N and R145I of HPV-33 E6, K93R of HPV-52 E6, K93N and PMID: 35086475
2022
BMC infectious diseases
Result: Six (6) new variants were identified based on the sequencing of the L1 region, HPV-16 (L441P, S343P), HPV-18 (S424P), HPV-45 (Q366H,
Discussion: However, two of them were found in only one sample (Y365F and F458L) and may have occurred by PCR amplification.
Discussion: Variants identified based on the sequencing of the L1 region are; HPV-16 (L441P, S343P), HPV-18 (S424P), HPV-45 (Q366H, Y365F), belonged to the HPV HR-HPV group and HPV-84 (F458L) for the LR-HPV group.
Development of a Spontaneous HPV16 E6/E7-Expressing Head and Neck Squamous Cell Carcinoma in HLA-A2 Transgenic Mice.
Abstract: IMPORTANCE Our data indicate that mutated HPV16 E6(R55K)(delK75) and mutated HPV16 E7(N53S) DNA abolishes the presentation of HPV16 E6 and E7 through murine MHC-I and results in their presentation through human HLA-A2 molecules.
Abstract: In addition, we tested the ability of E6(R55K)(delK75) and E7(N53S) for oncogenicity.
Abstract: Injection of DNA plasmids encoding LucE7(N53S)E6(R55K)(delK75), AKT, c-Myc, and SB100 followed by electroporation results in development of squa
Molecular insights into the interaction of HPV-16 E6 variants against MAGI-1 PDZ1 domain.
Result: E6 mutations Q14H, D25N, I27R, E29Q and H78Y are found in a non-domain region adjacent to the zinc finger domain 1.
Result: Concerning E-A176/G350 (blue), the equilibrium was reached at the first 20 ns, but a greater disturbance episode it's observed from 100 ns to the end of the trajectory it is also thought that the nature of mutation D25N in the proteins may contribute to this behavior.
Result: Mutations E29Q and D25N remained the same size; therefore, not visible change in 3D structure was observed.
Result: The mutation L83V found in all the variants can cause the proteins to lose interactions with other proteins because,
Prevalence and distribution of human papillomavirus (HPV) in Luoyang city of Henan province during 2015-2021 and the genetic variability of HPV16 and 52.
Discussion: In addition, there were 17 cases of E6<
Discussion: Our study found seven HPV16 E6 T295G and T350G nucleotide co-mutations, which may serve as a variant of the HPV16 European mutant strain.
Discussion: Studies have shown that HPV16 E6-T350G mutations in Moroccan women are prevalent in high-grade cervical lesions and are closely related to the progression of cervical cancer.
Discussion: There were 65 cases of E6 gene mutations at 350 nucleotides (T350G) with a mutation frequency of 63.64%, and corresponding amino acid change of leucine valine (L83V).
HPV mutation literature information.
PMID: 
2022
Auris, nasus, larynx
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