Virusliterature

HPV mutation literature information.

Predominance of genomically defined A lineage of HPV16 over D lineage in Indian patients from eastern India with squamous cell carcinoma of the cervix in association with distinct oncogenic phenotypes.

PMID: 34717279 2022 Translational oncology

Abstract: Among the A1 viruses, an association of variants in the E5 (Y44L, I65V), E6 (L83V) genes and LCR: C7577T with SCC, with combined Odd's ratio (95% CI) of 20.5(4.61-91.25) was observed.

Result: Additionally, 4 variants had significantly higher frequencies among non-malignant specimens [E1 (G1363A; G167S), L2 (A5063C; N276T), L2 (A5492C; I418T), and

Human papillomavirus 68 prevalence and genetic variability based on E6/E7 genes in Sichuan.

PMID: 34942562 2022 Virology

Abstract: N133S non-synonymous mutations of HPV 68 E6 and C67G, T68 A/M of HPV68 E7 are E6, E7 positive selection sites, they all located in the key domains and major motifs of E6/E7 protein, the above amino-acid substitutions changed the protein structure, disturbed the interaction with other protein or cellular factors and make a difference in epitopes affinity, may affect the pathogenicity and adaptability of HPV68 to the environment.

Genetic variation of E6, E7, and L1 genes of human papillomavirus 51 from central China.

PMID: 35048388 2022 Journal of medical virology

Abstract: Three nonconservative substitutions, T86P, S100L in E6, and F29L in E7, affected multiple hypothetical T-cell epitopes.

Abstract: Two nonconservative substitutions, H119Y and N176S in L1, affected multiple hypothetical B-cell epitopes.

The polymorphism analysis and epitope predicted of Alphapapillomavirus 9 E6 in Sichuan, China.

PMID: 35057815 2022 Virology journal

Abstract: Among which, 250 cases HPV-16 E6, 96 cases HPV-31 E6, 216 cases HPV-33 E6, 288 cases HPV-52 E6 and 405 cases HPV-58 E6 were successfully amplified, 17, 6, 6, 13, and 4 non-synonymous nucleotide mutations were respectively detected in HPV-16, 31, 33, 52, and 58 E6, 7 positive selection sites of alpha-9 HPV E6 were selected out (D32E of HPV-16 E6, K35N, K93N and R145I of HPV-33 E6, K93R of HPV-52 E6, K93N and

PMID: 35086475 2022 BMC infectious diseases

Abstract: Six (6) new deleterious mutations were identified in the HPV genotypes based on the sequencing of the L1 region, HPV-16 (L441P, S343P), HPV-18 (S424P), HPV-45 (Q366H, Y365F), and HPV-84 (F458L).

Result: Six (6) new variants were identified based on the sequencing of the L1 region, HPV-16 (L441P, S343P), HPV-18 (S424P), HPV-45 (Q366H, Y365F), belonging to the HPV HR-HPV group and HPV-84 (F458L) belonging to the LR-HPV group.

Table

Table: F458L

Development of a Spontaneous HPV16 E6/E7-Expressing Head and Neck Squamous Cell Carcinoma in HLA-A2 Transgenic Mice.

PMID: 35089069 2022 mBio

Abstract: IMPORTANCE Our data indicate that mutated HPV16 E6(R55K)(delK75) and mutated HPV16 E7(N53S) DNA abolishes the presentation of HPV16 E6 and E7 through murine MHC-I and results in their presentation through human HLA-A2 molecules.

Abstract: In addition, we tested the ability of E6(R55K)(delK75) and E7(N53S) for oncogenicity.

Abstract: Injection of DNA plasmids encoding LucE7(N53S)E6(R55K)(delK75), AKT, c-Myc, and SB100 followed by electroporation results in development of squa

Molecular insights into the interaction of HPV-16 E6 variants against MAGI-1 PDZ1 domain.

PMID: 35115618 2022 Scientific reports

Abstract: The aim of this work was to evaluate, with an in silico approach, employing molecular dynamics simulation and protein-protein docking, the interaction of the intragenic variants E-G350 (L83V), E-C188/G350 (E29Q/L83V), E-A176/G350 (D25N/L83V), E6-AAa (Q14H/H78Y/83V) y E6-AAc (Q14H/I27RH78Y/L83V) and E6-reference of HPV-16 with MAG

Genetic Diversity of HPV 16 and HPV 18 Based on Partial Long Control Region in Iranian Women.

PMID: 35126798 2022 The Canadian journal of infectious diseases & medical microbiology

Abstract: Also, among 14 SNPs in the HPV 18 LCR, C7577A and A7943T were not previously reported.

Abstract: Out of 27 SNPs in the HPV 16 LCR, A7382T, T7384G, C7387T, C7393G, A7431G, T7448C, and C7783A were HPV 16-specific.

Result: Also, in 100% of the samples, a T7595C mutation corresponded to the disappearance of binding sites of TFIID and TBP transcription factors.

Result: Compared to the HPV 18 reference, except for STi119 isolate, C7486T led to the emergence of binding sites for c-Fos and MBF1 in 93.0%

HPV16 E6 gene polymorphisms and the functions of the mutation site in cervical cancer among Uygur ethnic and Han nationality women in Xinjiang, China.

PMID: 35193568 2022 Cancer cell international

Abstract: Among 110 mutations, 65 cases of E6 genes were mutated at nucleotide 350 (T350G) with the leucine changing to valine (L83V).

Abstract: Moreover, there were 7 cases of E6 gene mutated at nucleotide 295 (T295G) with aspartic changing to glutamic (D64E).

Introduction: T178G is the most common polymorphic mutation in Asian strains, which causes aspartate to change to glutamine (D25E).

Introduction: T350G is the most common polymorphic mutation in European strains, which causes leucine to change to proline (L83V).

Prevalence and distribution of human papillomavirus (HPV) in Luoyang city of Henan province during 2015-2021 and the genetic variability of HPV16 and 52.

PMID: 35246180 2022 Virology journal

Abstract: For HPV16, The most prevalent mutations were T266A (27/27) and N181T (7/27) for L1, D32E for E6 and S63F for E7 in HPV16.

Abstract: For HPV52, all of the nucleotide changes were synonymous mutation in L1 (except L5S) and E7 genes.

Abstract: The K93R mutation was observed in most HPV52 E6 protein.

Result: All of the changes in HPV52 L1 gene were synonymous mutation except L5S (6.7%, 1/15).

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