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 HBV mutation literature information.


  Spontaneous reactivation of hepatitis B virus with S gene mutations in an elderly patient with diabetic nephropathy.
 PMID: 32519312       2020       Clinical journal of gastroenterology
1Abstract: Full-genome HBV sequence analysis revealed that the patient was infected with HBV of subgenotype B1 and it had an ""a"" determinant mutation M133L in the S gene coding HBsAg."


  Molecular characterization of hepatitis B virus isolated from Black South African cancer patients, with and without hepatocellular carcinoma.
 PMID: 32504396       2020       Archives of virology
Abstract: The following mutations were significantly more frequent in HCC cases than in controls (p < 0.05): in the BCP/PC 1753C/G (22.5% vs. 0%), 1764A (69.4% vs. 38.1%), and T64C (51.5% vs. 20%) in the preS2, which results in a F22L substitution.


  Anti-HBV activity of the HBV capsid assembly modulator JNJ-56136379 across full-length genotype A-H clinical isolates and core site-directed mutants in vitro.
 PMID: 32417895       2020       The Journal of antimicrobial chemotherapy
Abstract: Core amino acid substitutions in the CAM-binding pocket, when tested as SDMs at positions 23, 25, 30, 33, 37, 106, 110, 118, 124, 127 and 128, reduced JNJ-56136379 anti-HBV activity; EC50 fold increases ranged from 3.0 (S106T) to 85 (T33N).


  Novel hepatitis B virus surface antigen mutations associated with occult genotype B hepatitis B virus infection affect HBsAg detection.
 PMID: 32336003       2020       Journal of viral hepatitis
Abstract: E2G might cause HBsAg secretion impairment that results in intracellular accumulation and a decrease in HBsAg secretion.
Abstract: Five of the ten mutations (E2G, D144E, G145R, V168A and S174N) strongly decreased extracellular HBsAg level (P < .05) in the transfection system.
Abstract: Hence, ten mutations were associated with genotype B occult HBV infection; E2G and V168A were novel mutations which we confirmed significantly affect HBsAg detection.
Abstract: Notably, the E2G


  Key mutations in the C-terminus of the HBV surface glycoprotein correlate with lower HBsAg levels in vivo, hinder HBsAg secretion in vitro and reduce HBsAg structural stability in the setting of HBeAg-negative chronic HBV genotype-D infection.
 PMID: 32312174       2020       Emerging microbes & infections
Abstract: Results confirmed by multivariable analysis correcting for patients'demographics, HBV-DNA, ALT and infection-status.In genotype-D, specific C-terminus mutations (V190A-S204N-Y206C-Y206F-S210N) significantly correlate with HBsAg<1000IU/ml(P-value from <0.001 to 0.04).
Abstract: These mutations lie in divergent pathways involving other HBsAg C-terminus mutations: V190A + F220L (Phi = 0.41, P = 0.003), S204N + L205P (Phi = 0.36, P = 0.005), Y206F + S210R (Phi = 0.47, P < 0.001) and S210N +


  In silico Analysis of Genetic Diversity of Human Hepatitis B Virus in Southeast Asia, Australia and New Zealand.
 PMID: 32283837       2020       Viruses
Abstract: The three HBV variants identified most frequently were p.V5L, c.1896G>A and double mutation c.1762A>T/c.1764G>A, while genotypes B and C had the widest range of mutation types.


  Entecavir-resistant hepatitis B virus decreases surface antigenicity: A full genome and functional characterization.
 PMID: 32216026       2020       Liver international
Abstract: Additionally, the ETV resistance mutations rtT184A/L, rtS202G and rtM250V were found among three patients.
Abstract: More importantly, the rtI169T mutation in the RT domain, led to the sF161L mutation in the overlapping S gene, which decreased in surface antigenicity.
Abstract: RESULTS: The rtL180M + rtM204V mutations were common among all the clones analysed.


  [The prevalence clinically significant virus mutations among patients with chronic viral hepatitis B.]
 PMID: 32155009       2020       Klinicheskaia laboratornaia diagnostika
Abstract: Another 12.5% of the isolates are characterized by mutations that are independently associated with the liver cirrhosis and hepatocellular carcinoma development, including 21, 24, 27 nucleotides deletions in the Pre-S2 region and the S11F mutation in the PreCore region.


  A Hyper-Glycosylation of HBV Surface Antigen Correlates with HBsAg-Negativity at Immunosuppression-Driven HBV Reactivation in Vivo and Hinders HBsAg Recognition in Vitro.
 PMID: 32102257       2020       Viruses
Abstract: These NLGSs are located in the major hydrophilic region of HBsAg (known to be the target of antibodies) and resulted from the single mutation T115N, T117N, T123N, N114ins, and from the triple mutant S113N+T131N+M133T.
Method: Distances were calculated using MEGA 6.1 based on the Kimura-2 parameter (K2P) model.
Method: The following mutations associated with additional N-linked glycosylation sites were identified: 114N-ins, T115N, T117N, T123N, S113N+T131N+


  7-Deaza-7-fluoro modification confers on 4'-cyano-nucleosides potent activity against entecavir/adefovir-resistant HBV variants and favorable safety.
 PMID: 32084506       2020       Antiviral research
Abstract: Southern blot analysis using wild-type HBV (HBVWT)-encoding-plasmid-transfected HepG2 cells revealed that CdFA efficiently suppresses the production of HBVWT (IC50 = 153.7 nM), entecavir (ETV)-resistant HBV carrying L180M/S202G/M204V substitutions (HBVETVR; IC50 = 373.2 nM), and adefovir dipivoxil (ADV)-resistant HBV carrying A181T/N236T substitutions (HBVADVR; IC50=192.6 nM), whereas ETV and ADV were less potent against HBVETVR and HBVADVR (IC50: >1,000 and 4,022.5 nM, respectively).
Result: We then analyzed the interactions of ETV-TP and CdFA-TP with HBV-RT, in which three amino acid substitutions associated with HBV's resistance to ETV (L180M/S202G/M204V) have been



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