Abstract: The differences in dynamics when comparing HBV and human Cp149-Y132A as well as the differences in dynamics when comparing the HBV and WHV Cps allowed us to map an allosteric network within the HBV dimer.
Abstract: To understand what blocks assembly, we took advantage of an assembly incompetent mutant dimer, Cp149-Y132A, located in the interdimer interface.
Method: Dimer (hCp149, hCp149-Y132A, wCp149, and wCp149-Y132A) stocks at 2 mg mL-1 were diluted 1:10 into deuterated reaction buffer (10 mM HEPES, pD 7.5 in D2O).
Method: Four expression plasmids, pET11a-hCp149, pET11a-hCp149-Y132A, pET11a-wCp149 and pET11a-wCp149-Y132A, were transformed into E.
Identification of mutations in the S gene of hepatitis B virus in HIV positive Mexican patients with occult hepatitis B virus infection.
Abstract: A 25 mg JNJ-6379-treated patient had on-treatment enrichment of Y118F variant (HBV DNA decline 2.13 log10 IU/mL).
Abstract: One 75 mg JNJ-6379-treated patient had an emerging T109S substitution (FC = 1.8; HBV DNA decline 3.18 log10 IU/mL).
Abstract: Two JNJ-6379-treated patients carried a Y118F baseline core polymorphism known to reduce JNJ-6379 activity in vitro (FC = 6.6) and had HBV DNA declines of 2.77 (75 mg) and 2.19 log10 IU/mL (150 mg) at the end of treatment.
Hepatitis B virus mutation pattern rtA181S+T184I+M204I may contribute to multidrug resistance in clinical practice: Analysis of a large cohort of Chinese patients.
Abstract: Artificial elimination of rtA181S from the rtA181S + T184I + M204I mutant restored viral susceptibility to ADV but decreased viral replication capacity.
Abstract: Compared with wild-type, the rtA181S + T184I + M204I mutant had 53.7% lower replication capacity and >1000-, 3.9-, and 383.3-fold greater LAM, ADV, and ETV resistance, respectively, but remained sensitive to tenofovir.
Abstract: Longitudinal analysis of the clinical course of resistant mutant evolution for four representative cases showed that rtA181S + T184I
The genetic polymorphism down-regulating HLA-DRB1 enhancer activity facilitates HBV persistence, evolution and hepatocarcinogenesis in the Chinese Han population.
Abstract: rs3135395-T, rs477515-T and rs2395178-G were inversely associated with the generation of A1762T/G1764A, T1753V and C1653T, the HCC-risk HBV mutations.
[Relationship between mutations of HBV basal core promoter region in HBsAg-positive mothers and intrauterine transmission].
PMID: 32564557
2020
Zhonghua liu xing bing xue za zhi
Abstract: Conclusion: A1762T/G1764A double mutations of HBV DNA from the genotype C of those HBsAg-positive mothers could reduced the risk of HBV intrauterine transmission during pregnancy.
Abstract: Maternal A1762T/G1764A double mutations appeared to be possibly associated with neonatal HBeAg (P=0.050).
Abstract: Rates of A1762T/G1764A double mutations were significantly different between the intrauterine transmission group and the control group (7.53% vs.
Abstract: Results from the multivariate analysis showed that the A1762T/G1764A double mutations had reduced the risk of intrauterine transmission (aOR=0.065, 95%CI:
Impact of Lamivudine-Based Antiretroviral Treatment on Hepatitis B Viremia in HIV-Coinfected South Africans.
Abstract: Several lamivudine-associated HBV resistance mutations, including L180M, A181T, M204I, and M204V, were observed.
Result: Analysis of polymerase gene sequences from baseline and follow-up samples showed the presence of resistance-associated mutations in 5 of these 6 patients, including L180M, A181T, M204I, and M204V (Table 5).
Result: At baseline, patient ZA164 was HBsAg-positive with 7.67 x 103 IU/mL HBV DNA and the M204I variant.
Result: At the final visit at 6 months, HBV DNA level had dropped to 2.42 x 103 IU/mL, the M204I variant was not dete
Analysis of HBsAg mutations in the 25 years after the implementation of the hepatitis B vaccination plan in China.
Abstract: HBV strains with internal stop codons of HBsAg (e.g., sC69*) and additional N-glycosylation (e.g., sG130N) mutations should be studied extensively to prevent them from becoming dominant circulating strains.
Complete genome analysis of hepatitis B virus in Qinghai-Tibet plateau: the geographical distribution, genetic diversity, and co-existence of HBsAg and anti-HBs antibodies.
Abstract: Clinical prognosis-related genetic variations such as nucleotide mutation T1762/A1764 (27.93%), A2189C (12.85%), G1613A (8.94%), T1753C (8.38%), T53C (4.47%) T3098C (1.68%) and PreS deletion (2.23%) were detected in CD recombinants.
Discussion: In this study, the A1762T/G1764A double mutations were observed in 27.93% in HBV CD recombinant sequences.
Discussion: Other mutations, such as T53C, G1613A, C1653T, T1753C, A2189C, T3098C and PreS
HBV mutation literature information.
PMID: 
2020
Clinica chimica acta; international journal of clinical chemistry
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