Virologic analysis of tenofovir resistance in a patient with chronic hepatitis B experiencing viral breakthrough during combination treatment with tenofovir disoproxil fumarate and entecavir.
Abstract: A recent Korean report showed that two patients with viral breakthrough during treatment with TDF-containing regimens were found to carry five reverse transcriptase (rt) mutations ([rt]S106C[C], rtH126Y[Y], rtD134E[E], rtM204I/V, and rtL269I [I]), with the C, Y, E, and I mutations being associated with tenofovir resistance.
Abstract: Four mutations (rtS106C, rtD134N/S[N/S], rt
High Prevalence of Preexisting HBV Polymerase Mutations in Pregnant Women Does Not Limit the Antiviral Therapy Efficacy.
PMID: 33986897
2021
The Canadian journal of infectious diseases & medical microbiology
Abstract: Among them, 75.0% of patients with rtM204I positive had HBV DNA load >=103 IU/mL at delivery, which was comparable with the subjects without rtM204I (75.0% vs.
Abstract: No changes were found in the frequencies and the complexity of HBV quasispecies of rtM204I mutation after the TVB treatment.
Abstract: RESULTS: Before TBV treatment, the complexity of HBV quasispecies of all subjects was 0.40 +- 0.09; 41.1% (30/73) and 53.4% (39/73) subjects had rtM204I/V and rtN236 T/A detected, respectively; and 9.6% (7/73) patients had more than 20% frequency mutation of rt PMID: 33453326
2021
Journal of hepatology
Abstract: An analysis of the effect of Cp mutants on intracellular or extracellular viral protein production indicated that the W62R mutation in Cp had a critical impact on the reduction of HBcAg and HBeAg production during HBV replication, whereas P50H and/or S74G mutations played a limited role in influencing viral protein production invivo.
Abstract: CONCLUSIONS: W62R and its combination mutations in HBV Cp might massively affect HBcAg and HBeAg production during viral replication, which, in turn, might contribute to the occurrence of OBI.
Abstract: The <
Prevalence and characteristics of hepatitis B and D virus infections among HIV-positive individuals in Southwestern Nigeria.
Abstract: The basal core promoter (BCP) variants, A1762T and G1764A, and the pC variant, G1896A, were most often enriched at or after seroconversion.
Recombinant HBsAg of the Wild-Type and the G145R Escape Mutant, included in the New Multivalent Vaccine against Hepatitis B Virus, Dramatically Differ in their Effects on Leukocytes from Healthy Donors In Vitro.
PMID: 34007795
2021
Journal of clinical and translational hepatology
Abstract: A plasmid containing the M204V mutation was synthesized and standard curves plotted.
Abstract: CONCLUSIONS: These results show that our method can be used to detect HBV M204V mutations with the advantages of sensitivity, specificity and efficiency, providing a new choice for monitoring drug resistance.
Result: Both real-time PCR and direct sequencing protocols indicated that 13 out of the 32 samples (40.625%) were M204V-positive.
Result: Eighteen samples (56.25%) were identified as M204V-negative by both real-time PCR and direct sequencing.
Result: None of the samples were found to be M204V false positives.
Result: One sample (3.125%) was identified as M204V-positive by direct sequencing, whereas the real-time PCR results could not be eva
Identification of a novel long-acting 4'-modified nucleoside reverse transcriptase inhibitor against HBV.
Abstract: E-CFCP also reduced HBVETV-RL180M/S202G/M204V-viremia by 2 logs over 2 weeks, while ETV completely failed to reduce HBVETV-RL180M/S202G/M204V-viremia.
Abstract: E-CFCP's 4'-cyano and fluorine interact with both HBVWT-RT and HBVETV-RL180M/S202G-M204 -RT via Van der Waals and polar forces, being important for E-CFCP-triphosphate's interactions and anti-HBV potency.
Abstract: RESULTS: E-CFCP potently blocked HBVWTD1 production (IC50qPCR_cell=1.8 nM) in HepG2.2.15 cells and HBVWTC2 (IC50SB_cell=0.7 nM), entecavir (ETV)-resistant HBVETV-RL180M/S202G/
Precore and Basal Core Promoter Hepatitis B Virus (HBV) Variants Are Present From a Young Age and Differ Across HBV Genotypes.
Abstract: CONCLUSIONS: PC variants can be present in HBV genotype A and are usually associated with C1858T, which preserves the pregenome encapsidation sequence.
Abstract: Seventeen of 20 participants with genotype A and PC had a compensatory C1858T mutation.
Hepatitis B in the Northwestern region of Sao Paulo State: genotypes and resistance mutations.
PMID: 34755817
2021
Revista do Instituto de Medicina Tropical de Sao Paulo
Abstract: Resistance mutations (rtM204V/I/S) associated or not with compensatory mutations (rtL180M, rtV173L) were identified in 13.9% (5/36) of patients undergoing viral treatment and 1.1% (1/90) of naive patients.
Result: In the group of patients undergoing treatment, strains of HBV with resistance mutations (rtM204V/I/S) associated or not with compensatory mutations (rtL180M, rtV17
Table: L180M
Table: M204V
Table: V173L
AutoVEM2: A flexible automated tool to analyze candidate key mutations and epidemic trends for virus.
PMID: 34512928
2021
Computational and structural biotechnology journal
Result: 5 of the 7 sites were missense mutations, including 356S>A (T192G), 444S>P (T456C), 807D>V (A1546T), 10R>K (G2337A) on P gene, and 331A>V (C
Discussion: Among them, some mutations, such as D614G and N501Y of SARS-CoV-2, T350G of HBV, and C659T of HVP-16, have been proved to play an important role in the viruses, indicating the reliability and effectiveness of AutoVEM2.
Discussion: For HBV, the C659T mutation, which causes A331V mutation on S gene, is reported to be associated with increasing the efficiency of HBV replication.
HBV mutation literature information.
PMID: 
2021
Hepatology research
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