High Prevalence of Preexisting HBV Polymerase Mutations in Pregnant Women Does Not Limit the Antiviral Therapy Efficacy.
PMID: 33986897
2021
The Canadian journal of infectious diseases & medical microbiology
Abstract: Among them, 75.0% of patients with rtM204I positive had HBV DNA load >=103 IU/mL at delivery, which was comparable with the subjects without rtM204I (75.0% vs.
Abstract: No changes were found in the frequencies and the complexity of HBV quasispecies of rtM204I mutation after the TVB treatment.
Abstract: RESULTS: Before TBV treatment, the complexity of HBV quasispecies of all subjects was 0.40 +- 0.09; 41.1% (30/73) and 53.4% (39/73) subjects had rtM204I/V and rtN236 T/A detected, respectively; and 9.6% (7/73) patients had more than 20% frequency mutation of rt PMID: 33462964
2021
Hepatology research
Abstract: A recent Korean report showed that two patients with viral breakthrough during treatment with TDF-containing regimens were found to carry five reverse transcriptase (rt) mutations ([rt]S106C[C], rtH126Y[Y], rtD134E[E], rtM204I/V, and rtL269I [I]), with the C, Y, E, and I mutations being associated with tenofovir resistance.
Abstract: Four mutations (rtS106C, rtD134N/S[N/S], rt
Molecular characteristics of HBV infection among blood donors tested HBsAg reactive in a single ELISA test in southern China.
Abstract: A high-frequency mutation, T1719G (93.3%), was detected in the BCP/PC region, which reduced the viral replication.
Abstract: Mutations were found in the S gene, including Y100C, Y103I, G145R, and L175S, which can affect the detection of HBsAg.
Result: As shown in Table 2, 45.5% (5/11, 45.5%) S regions in 11 HBV-B isolates had N40S mutations.
Result: In addition, immune escape mutants containing Q129H, T131I/T, G145R, and E164V we
Distinctive HBV Replication Capacity and Susceptibility to Tenofovir Induced by a Polymerase Point Mutation in Hepatoma Cell Lines and Primary Human Hepatocytes.
PMID: 33562603
2021
International journal of molecular sciences
Discussion: Additionally, as its region is not overlapped with surface gene either, the effect of the rtT301A mutation may be solely attributed to itself.
Discussion: As the next step, molecular modeling of RT mutants would be helpful to elucidate the role and mechanism of the rtT301A mutation in viral fitness.
Discussion: Discovery of the rtT301A mutation at the nadir point of HBV DNA during TDF treatment may have captured the evolution process of the tenofovir-resistant virus.
Discussion: Further investigation is required to know whether endogenous cofactors are possibly associated with HBV polymerase, and if so, whether their properties are altered by
Multiple drug-resistant HBV mutation may contribute to poor response of adefovir + entecavir in entecavir-resistant patients.
PMID: 33571155
2021
Journal of infection in developing countries
Abstract: RESULTS: ETV-resistant mutants were continuously detected in 10 of the 12 patients, and multidrug-resistant (MDR) mutants, including a novel strain (rtL180M+A181V+T184A+S202G+M204V), were detected in two patients.
Entecavir resistance in a patient with treatment-naive HBV: A case report.
PMID: 33903819
2021
Molecular and clinical oncology
Abstract: Only the substitution M204I was detected in the HBV polymerase region.
Conclusion: ETVr-related substitution M204I was detected, but no other mutations were identified (Table II).
Introduction: In fact, resistance to ETV appears to occur through a two-hit mechanism with primary LVD resistance (LVDr) substitutions (M204V/I with/without rtL180M) followed by amino acid substitutions at the rtI169, rtT184, rtS202 or rtM250 sites.
Discussion: Analysis of HBV resistance was not performed prior to treatment in the present case, and thus, whether the baseline rt
Recombinant HBsAg of the Wild-Type and the G145R Escape Mutant, included in the New Multivalent Vaccine against Hepatitis B Virus, Dramatically Differ in their Effects on Leukocytes from Healthy Donors In Vitro.
PMID: 33857724
2021
Journal of infection and public health
Abstract: G1896A switch is one of the hotspots in subjects affected with hepatitis B.
Abstract: Almost 29% (24/82) of the cases remarkably had the presence of G1896A mutation confirmed by LCR and direct sequencing.
Abstract: Polymerase chain reaction (PCR) and Nucleotide Sequencing was done to identify the G1896A mutation in the precore region of the genome.
Abstract: The precore G1896A mutation is responsible for one third of the patients suffering from precore stop codon mutation.
Abstract: The major purpose of the study was to screen G1986A mutations at a large scale and also to establish ligase chain reaction as a mutation testing tool.
Global prevalence and phylogeny of hepatitis B virus (HBV) drug and vaccine resistance mutations.
Abstract: RAM M204I/V had the highest prevalence, occurring in 3.8% (109/2838) of all HBV sequences in our data set, and a significantly higher rate in genotype C at 5.4% (60/1102, p = 0.0007).
Introduction: G145A/R is the best described mutation associated with resistance to HBV vaccine/HBIg.
Discussion: A previous meta-analysis estimated the prevalence of M204I/V as 4.9% among >12,000 treatment-naive indi
Natural variability in surface antigen and reverse transcriptase domain of hepatitis B virus in treatment-naive chronic HBV-infected Egyptian patients.
Abstract: Additionally, 11 occult samples (19 %) were detected, in which the predominant mutations of HBsAg were S143L (7 samples) followed by D144A and T125M (4 samples each).
Abstract: Additionally, we detected viral quasispecies and revealed Y124H as a characteristic substitution in the RT domain for HBV isolates in Egypt.
Abstract: Eleven substitutions were found in the major hydrophilic region, including two novel ones (M103T and G130E) that were not correlated before with genotype D.
Abstract: The most predominant mutation was Y124H (47 samples, 82 %).
Identification of hepatitis B virus core protein residues critical for capsid assembly, pgRNA encapsidation and resistance to capsid assembly modulators.
HBV mutation literature information.
PMID: 
2021
The Canadian journal of infectious diseases & medical microbiology
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