Virusliterature

HBV mutation literature information.

Establishment of monoclonal antibodies broadly neutralize infection of hepatitis B virus.

PMID: 35084739 2022 Microbiology and immunology

Abstract: In addition, the antibodies neutralized the infection of hepatitis D virus possessing a Gly145 mutation to Arg in S protein, which is a well-known escape mutation against HBIG treatment.

Dried blood spot sampling for hepatitis B virus quantification, sequencing and mutation detection.

PMID: 35102169 2022 Scientific reports

Abstract: An HIV-coinfected patient presented the rtM204V/I-rtL180M double resistance mutation in serum and DBS.

Discussion: As demonstrated by Mello et al., Y100C alone may not affect HBsAg production, secretion or HBsAg affinity by commercial serological assays, as for our samples.

Discussion: In addition, L109R/V mutations were present in 2/10 samples and have been related to HBV vaccine escape and virus evasion to the host immune system.

Discussion: Overall, Y100C was the most frequent substitution, being present in 6/10 sequenced samples.

Identification and Characterization of Besifovir-Resistant Hepatitis B Virus Isolated from a Chronic Hepatitis B Patient.

PMID: 35203489 2022 Biomedicines

Abstract: As a result, our study revealed that rtL180M (M) and rtM204V (V) mutations, already known as lamivudine-resistant mutations, confer resistance to BSV in the CHB patient.

Abstract: The ten mutations include rtV23I (I), rtH55R (R), rtY124H (H), rtD134E (E), rtN139K (K), rtL180M (M), rtM204V (V),

Recombinant HBsAg of the Wild-Type and the G145R Escape Mutant, included in the New Multivalent Vaccine against Hepatitis B Virus, Dramatically Differ in their Effects on Leukocytes from Healthy Donors In Vitro.

PMID: 35214692 2022 Vaccines

Discussion: As such, a vaccine containing both wild-type and the G145R mutant HBsAg can also confer immunity to both types of the virus.

Discussion: At the same time, the inability of HBsAg with the G145R mutation to enhance the expression of CD86 on B cells may indicate a lack of a compensatory mechanism in this escape mutant.

Discussion: Comparative studies of sera from people who were vaccinated with monovalent vaccines and those recovered from HBV infection have demonstrated that only sera of the recovered patients contained highly active antibodies against both the G145R mutant HBsAg and wild-type HBsAg.

Discussion: Evaluation of cytokine production by PBMC from healthy donors in re

Comparative analysis of HBV basic core promoter/pre-core gene mutations and viral quasispecies diversity in HIV/HBV co-infected and HBV mono-infected patients.

PMID: 35380862 2022 Acta virologica

Abstract: Among the patients infected with HBV genotype C and HBeAg-negative status, the frequency of A1762T/G1764A double mutations was significantly lower in HIV/HBV co-infected patients than in HBV mono-infected patients (53.3% vs.

Abstract: However, A1762T/G1764A double mutations did not differ in the other groups (P >0.05).

Reactivation of Occult Hepatitis B Virus Infection During Long-Term Entecavir Antiviral Therapy.

PMID: 35359734 2022 Frontiers in microbiology

Abstract: Genetic sequencing of HBV showed the mutants of S143T, D144G, and G145R in the S gene region, and the mutant of site 1896 in the pre-Core region coexisted with the wild type (G1896A/G).

Table: <

Table: A181S

Table: A181T

Molecular characterization of hepatitis B virus (HBV) isolated from a pediatric case of acute lymphoid leukemia, with a delayed response to antiviral treatment: a case report.

PMID: 35361141 2022 BMC pediatrics

Table: A11T

Table: A1480G

Table: A1511G

Table: A2092T

Table: A47T

Table: A895G

Table: A928T

Table: C1060A

Table: C144T

Table: C324T

Table: D36G

Table: E64D

Table: G1461C

Table: G3039T

Table: G68W

Table: L100I

Table: L311I

Table:

PMID: 35454370 2022 Medicina (Kaunas, Lithuania)

Result: M204V/I: 48.8%, plus L180M: 33.3% +- L80V: 28.8% and V173L: 42.2%:a profile suggestive for LAM resistance (with all mutations, except for M204V, also being associated with telbivudine resistance, and the combination of L180M, M204V, andV173L being associated with entecavir (ETV) resistance.

Result: N236T: 28.8% and A181T/V: 15.5%:a profile suggestive for ADV resistance (and associated with reduced susceptibility to TDF/TAF).

Result: There were no significant differences in the distribution of RAMs in patients infected with different HBV genotypes, except for the compensatory L80V mutation and the adefovir (ADV) resi

Prevalence, genotype distribution and mutations of hepatitis B virus and the associated risk factors among pregnant women residing in the northern shores of Persian Gulf, Iran.

PMID: 35271684 2022 PloS one

Discussion: Moreover, the BCP A1762T and G1764A mutations are reported in association with HBV genotypes C and D.

Discussion: Nevertheless, P120T and G145R mutations associated with failure of HBsAg detection were not found in this sample.

Discussion: Notably, the sample with G1896A mutation was HBeAg negative.

Discussion: Of these, the pre-C mutation (G1896A) eliminates HBeAg expression at the translational level, whereas BCP mutations (G1764A) decrease HBeAg expression

Mutations in the HBV PreS/S gene related to hepatocellular carcinoma in Vietnamese chronic HBV-infected patients.

PMID: 35390033 2022 PloS one

Abstract: Most of S point-mutations were presented with low rates such as T47A/E/V/K (9.3%), P120S/T (8.5%), G145R (2%).

Abstract: On multivariable analysis, males (OR = 4.51, 95%CI 1.78-11.4, p = 0.001), age>=40 (OR = 5.5, 95%CI 2.06-14.68, p = 0.001), W4P/R/Y on PreS1 (OR = 11.56, 95%CI 1.99-67.05, p = 0.006) and 4 S point-mutations as: T47A/E/V/K (OR = 3.67, 95%CI 1.19-11.29, p = 0.023), P120S/T (OR = 3.38, 95%CI 1.09-10.49, p = 0.035), S174N (OR = 29.73, 95%CI 2.12-417.07, p = 0.012), P203R (OR = 8.45, 95%CI 1.43-50.06, p = 0.019) were associated with

Browser Board

Co-occurred Entities

Filtrator