Abstract: An HIV-coinfected patient presented the rtM204V/I-rtL180M double resistance mutation in serum and DBS.
Discussion: As demonstrated by Mello et al., Y100C alone may not affect HBsAg production, secretion or HBsAg affinity by commercial serological assays, as for our samples.
Discussion: In addition, L109R/V mutations were present in 2/10 samples and have been related to HBV vaccine escape and virus evasion to the host immune system.
Discussion: Overall, Y100C was the most frequent substitution, being present in 6/10 sequenced samples.
Discussion: Regarding resistance mutations, the double rt
Identification and Characterization of Besifovir-Resistant Hepatitis B Virus Isolated from a Chronic Hepatitis B Patient.
Result: HBV RT rtL180M and rtM204V Mutations Are Associated with BFV Resistance.
Result: Since the previous reports showed that two mutations (
Recombinant HBsAg of the Wild-Type and the G145R Escape Mutant, included in the New Multivalent Vaccine against Hepatitis B Virus, Dramatically Differ in their Effects on Leukocytes from Healthy Donors In Vitro.
Discussion: As such, a vaccine containing both wild-type and the G145R mutant HBsAg can also confer immunity to both types of the virus.
Discussion: At the same time, the inability of HBsAg with the G145R mutation to enhance the expression of CD86 on B cells may indicate a lack of a compensatory mechanism in this escape mutant.
Discussion: Comparative studies of sera from people who were vaccinated with monovalent vaccines and those recovered from HBV infection have demonstrated that only sera of the recovered patients contained highly active antibodies against both the G145R mutant HBsAg and wild-type HBsAg.
Discussion: Evaluation of cytokine production by PBMC from healthy donors in re
Prevalence, genotype distribution and mutations of hepatitis B virus and the associated risk factors among pregnant women residing in the northern shores of Persian Gulf, Iran.
Abstract: Of note, the conversion of Ala Val at amino acid 168 (A168V) and Thr Pro at amino acid 127 (T127P) were detected in HBsAg of the occult HBV strain.
Discussion: Moreover, the BCP A1762T and G1764A mutations are reported in association with HBV genotypes C and D.
Discussion: Nevertheless, P120T and G145R mutations associated with failure of HBsAg detection were not found in this sample.
Discussion: Notably, the sample with G1896A mutation was HBeAg negative.
Discussion: Of these, the pre-C mutation ( PMID: 35487093
2022
Journal of clinical virology
Abstract: H35N was maintained during final tenofovir treatment.
Abstract: CONCLUSIONS: Our findings indicate that changes at the conserved residue 35 (H35N/Q) in the HBV RT may be associated with tenofovir resistance.
Abstract: Two RT mutations (H35N and P237T) emerged during subsequent 5-year entecavir treatment.
Abstract: Two of the SNPs were in the reverse transcriptase (RT; H35Q and D263E).
Hepatitis B Virus Genotypes and Antiviral Resistance Mutations in Romanian HIV-HBV Co-Infected Patients.
Result: M204V/I: 48.8%, plus L180M: 33.3% +- L80V: 28.8% and V173L: 42.2%:a profile suggestive for LAM resistance (with all mutations, except for M204V, also being associated with telbivudine resistance, and the combination of L180M, M204V, andV173L being associated with entecavir (ETV) resistance.
Result: N236T: 28.8% and A181T/V: 15.5%:a profile suggestive for ADV resistance (and associated with reduced susceptibility to TDF/TAF).
Result: There were no significant differences in the distribution of RAMs in patients infected with different HBV genotypes, except for the compensatory L80V mutation and the adefovir (ADV) resi
Precore/core mutations of hepatitis B virus genotype D arising in different states of infection.
PMID: 35415256
2022
Clinical and experimental hepatology
Discussion: The substitution Discussion: There were some variations such as E77Q, E113Q, S181P/H and Q182K/*Stop outside of the epitope regions which have previously been reported to accumulate with disease progression.
Discussion: They also found that F24Y, E64D, and V91S/T mutations were located in the T-cell epitope regions, and E77Q, A80I/T/V, and L116I were located within the B-cell epitope regions.
Discussion: reported that 31.8% (14/44) of patients had mutations in the precore region (G1896A).
Mutations in the HBV PreS/S gene related to hepatocellular carcinoma in Vietnamese chronic HBV-infected patients.
Abstract: Most of S point-mutations were presented with low rates such as T47A/E/V/K (9.3%), P120S/T (8.5%), G145R (2%).
Abstract: On multivariable analysis, males (OR = 4.51, 95%CI 1.78-11.4, p = 0.001), age>=40 (OR = 5.5, 95%CI 2.06-14.68, p = 0.001), W4P/R/Y on PreS1 (OR = 11.56, 95%CI 1.99-67.05, p = 0.006) and 4 S point-mutations as: T47A/E/V/K (OR = 3.67, 95%CI 1.19-11.29, p = 0.023), P120S/T (OR = 3.38, 95%CI 1.09-10.49, p = 0.035), S174N (OR = 29.73, 95%CI 2.12-417.07, p = 0.012), P203R (OR = 8.45, 95%CI 1.43-50.06, p = 0.019) were associated with
Comparative analysis of HBV basic core promoter/pre-core gene mutations and viral quasispecies diversity in HIV/HBV co-infected and HBV mono-infected patients.
Abstract: Among the patients infected with HBV genotype C and HBeAg-negative status, the frequency of A1762T/G1764A double mutations was significantly lower in HIV/HBV co-infected patients than in HBV mono-infected patients (53.3% vs.
Abstract: However, A1762T/G1764A double mutations did not differ in the other groups (P >0.05).
Recombinant HBsAg of the Wild-Type and the G145R Escape Mutant, included in the New Multivalent Vaccine against Hepatitis B Virus, Dramatically Differ in their Effects on Leukocytes from Healthy Donors In Vitro.
Abstract: CONCLUSION: ELISA-based detection of escape mutations S143L, D144E and G145R can be used for routine diagnostics, especially in the risk groups.
Abstract: The G145R mutation was recognized using ELISA kit in almost all cases.
Abstract: The kit specifically recognized the S143L substitution in contrast to the S143T variant.
Abstract: The presence of neighbor mutation D144E can be assumed due to it special serological fingerprint.
HBV mutation literature information.
PMID: 
2022
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