Abstract: Most OBI strains were wild-type HBV, but some substitutions V168A, S174 N, V177A, Q129R/L/H, G145A/R in S region of genotype B (OBIB) and T47K/V/A, P49H/L, Q101R/H/K, S174 N, L175S, V177A, T118 M/R/K, G145R/A/K/E, R160K/N in S region of genotype C (OBIC) strains were identified in high frequency.
R
Nucleotide Substitutions in Hepatitis B Viruses Derived from Chronic HBV Patients.
PMID: 31308922
2019
Mediterranean journal of hematology and infectious diseases
Result: A1762T and G1764A were frequently detected together in 23.0% (6/26) of the isolates.
Result: A high proportion (61.0%, 16/26) of G1896A mutation occurred in the PC region.
Result: Also, AST was significantly higher among patients with F8L HBV mutants (P=0.001) (Table 3).
Result: Five (5) mutations were detected within the surface gene in the patients (F8L, T118M, E164D, T189I, and W196L).
Result: However, none of the patients with A1762T/G1764A mutation carried the G1
Large-scale viral genome analysis identifies novel clinical associations between hepatitis B virus and chronically infected patients.
Discussion: C1653T exhibited only marginal signal with viral load.
Discussion: Although G1896A had the most significant association with HBeAg status, we identified other variants that were important for understanding a patient's HBeAg status.
Discussion: Although patients with high frequency of C1817T and A1838G variants experienced earlier viral suppression while on treatment, given the effectiveness of the latest reverse transcriptase inhibitors, the difference in viral load reduction diminishes after 48 weeks.
Discussion: Given its proximity to the transcription start site, we hypothesize that C1817T affects the transcriptional regulation of pgRNA leading to the reduction of the viral loa
Association Between HBx Variations and Development of Severe Liver Disease Among Indonesian Patients.
PMID: 31341154
2019
The Kobe journal of medical sciences
Abstract: However, the roles of two novel X gene mutations (A12S/T and L16F/P) on hepatocarcinogenesis are unclear relative to wild-type X gene.
Abstract: In addition, the double mutation K130M/V131I and the triple mutation N88V/K130M/V131I were associated with a 2.5 times higher risk of advanced liver disease.
Locus 5p13.1 may be associated with the selection of cancer-related HBV core promoter mutations.
PMID: 31341412
2019
International journal of medical sciences
Abstract: Background: The basal core promoter (BCP) double mutations (A1762T and G1764A) of hepatitis B virus (HBV) have been reported to be an aetiological factor of hepatocellular carcinoma (HCC).
Introduction: The precore mutation (G1896A), mutations in Discussion: In summary, our study provides evidence using GWAS that host genetic polymorphisms are associated with the immune selection of HCC-related double mutations (A1762T and G1764A) in the basal core promoter of HBV.
Next generation sequencing identifies baseline viral mutants associated with treatment response to pegylated interferon in HBeAg-positive chronic hepatitis B.
Abstract: Based on NGS, the prevalence of T1753V (T1753C/A/G) and A1762T/G1764A variants were significantly lower in responders compared to non-responders (8.3% vs.
Abstract: No significant difference between groups was found regarding C1653T and G1896A mutants.
Abstract: The absence of T1753V and A1762T/G1764A mutations were factors associated with CR (OR 11.65, 95%CI 1.36-100.16, P = 0.025, and OR 4.36, 95%CI 1.08-17.63, P = 0.039, respectively).
Abstract: The existence of pre-treatment T1753V, A1762T/G1764A mutations and thei
Recombinant HBsAg of the Wild-Type and the G145R Escape Mutant, included in the New Multivalent Vaccine against Hepatitis B Virus, Dramatically Differ in their Effects on Leukocytes from Healthy Donors In Vitro.
Abstract: All mutations simultaneously created a stop codon at sC69 (sC69*).
Abstract: Artificial elimination of the rtS78T mutation had a limited effect on the drug susceptibilities.
Abstract: The HBV DNA and RNA levels of the rtS78T/sC69* mutant w
Abstract: The data obtained in the present study suggested that the emergence of the rtS78T/sC69* mutation was not closely related to entecavir/tenofovir treatment and itself appeared insufficient to confer drug resistance unless it coexisted with signature drug-resistance mutations.
rt269I Type of Hepatitis B Virus (HBV) Leads to HBV e Antigen Negative Infections and Liver Disease Progression via Mitochondrial Stress Mediated Type I Interferon Production in Chronic Patients With Genotype C Infections.
Abstract: Our epidemiological study showed HBeAg negative infections of rt269I infections were attributed to a higher frequency of preC mutations at 1896 (G to A).
Introduction: We recently introduced some mutations in the reverse transcriptase (RT) region of Pol related to HCC from genotype C infected patients [rtM80I, rtN139K/T/H, and rtM204I/V].
Table: A1762T
Table: G1764A
High possibility of hepatocarcinogenesis in HBV genotype C1 infected Cambodians is indicated by 340 HBV C1 full-genomes analysis from GenBank.
Result: 2), among the 16 isolates from our study located in cluster c, 15 isolates had the A1762T/G1764A mutation and 12 isolates had combination mutation (Table 3).
Result: Based on the presence or absence of the mutations of pre-S deletion, G1613A, C1653T, T1753V, A1762T/G1764A, Pre-C W28 stop codon, and P130, these 340 genotype C1 strains were classified in 48 patterns.
Result: Combination mutation at T1753V and A1762T/G1764A was most frequent.
Result: double mutation at
Recombinant HBsAg of the Wild-Type and the G145R Escape Mutant, included in the New Multivalent Vaccine against Hepatitis B Virus, Dramatically Differ in their Effects on Leukocytes from Healthy Donors In Vitro.
PMID: 31442597
2019
Infection, genetics and evolution
Abstract: Among different substitution types at sI126, the sI126T (N = 28) was found to be associated with significantly lower serum HBsAg level.
Abstract: Clone sequencing revealed that sI126T-harboring SHBs sequences had varied genetic backbones with zero to nine additional AA substitutions.
Abstract: Our findings suggest that the modulation of HBsAg level by sI126T is affected by additional AA substitution(s) in the S region of HBV.
Abstract: Thus, we constructed 24 HBsAg expression plasmids harboring s
HBV mutation literature information.
PMID: 
2019
BMC infectious diseases
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