Abstract: An S mutant (residue 126, Thr to Ala) initially found in an infant with fulminant hepatitis was replaced by another S mutant (residue 145, Gly to Arg) 4 days later.
Precore codon 28 stop mutation in hepatitis B virus from patients with hepatocellular carcinoma.
PMID: 9439156
1997
The Korean journal of internal medicine
Abstract: OBJECTIVES: Hepatitis B virus (HBV) with a stop mutation at precore codon 28 (TGG-->TAG, tryptophan-->stop) was investigated to clarify if such a mutant virus might play a role in hepatocarcinogenesis.
[In vitro expression of wild type and precore mutant woodchuck hepatitis virus].
PMID: 15619810
1997
Zhonghua shi yan he lin chuang bing du xue za zhi
Abstract: Hepatitis B virus (HBV) precore 1896 and 1898 G-->A mutations are regarded as hot spots to study.
A Hepatitis B Virus Variant with an Ile to Ser Mutation at aa126 of HBsAg.
PMID: 12232637
1996
Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica
Abstract: As aa126 is located in the first loop of the two-looped conformational structure of the determinant, and the Ile to Ser at aa 126 is a drastic change, it is suggested that the antigenicity of the HBsAg might be altered and the immune failure in patient No.19 was probably related to the mutation.
Abstract: There was a G at nt 531 instead of T, leading to a change of Ile to Ser at aa126 of the major HBsAg.
[Identification of vertical transmission of hepatitis B virus from mother to children by direct sequencing a segment of surface gene of hepatitis B virus].
Abstract: In one child of family three, with coexisted HBsAg and anti-HBs, sequencing result revealed a point mutation which predicted a change from glycine to arginine at residue 145 in the second loop of the determinant.
Hepatitis B virus carriers without precore mutations in hepatitis B e antigen-negative stage show more severe liver damage.
Abstract: The G-->A mutation at nucleotide 1896 may mediate viral escape by creating a TAG stop codon in the precore region, thus preventing HBeAg production.
Complete nucleotide sequences of hepatitis B virus genomes associated with epidemic fulminant hepatitis.
Abstract: One was located in the pre-surface 1 gene; two were in the surface gene; three were in the pre-core gene, including codons 28 (tryptophan to stop codon) and 29 (glycine to aspartic acid); eight were in the core gene; and 11 were in the polymerase gene.
Rare pre-core stop-codon mutant nt. 1897 predominates over wide-spread mutant nt. 1896 in an unusual course of chronic hepatitis B.
Abstract: Direct sequencing of polymerase chain reaction (PCR) products derived from consecutive sera showed a rare pre-core stop-codon mutation at nucleotide (nt.) 1897 G --> A with an accompanying mutation nt. 1857 C --> T as well as a stop-codon mutation nt. 1896 G --> A.
Pre-core mutants of hepatitis B virus in patients receiving immunosuppressive treatment after orthotopic liver transplantation.
Abstract: In one of eight patients in addition to wildtype HBV a mutant strain (nt. 1899 G-->A) was detected.
Abstract: In one of the latter two, a pre-core start-codon mutant (nt. 1816 G-->T), not detectable before OLT, emerged, in the other a nt. 1897 G-->A stop-codon mutant persisted.
Abstract: Six of nine patients of group B were reinfected with the same mutant population; in one, an additional pre-core mutation emerged; two patients lost pre-core mutant HBV (nt. 1896 and 1899 G-->A).
Mutations in the hepatitis B virus precore/core gene and core promoter in patients with severe recurrent disease following liver transplantation.
Abstract: Previously, we reported that infection with HBV strains containing a mutation in the precore region (G-to-A at nucleotide 1896) was associated with severe recurrent disease posttransplantation.
HBV mutation literature information.
PMID: 
1997
Hepatology (Baltimore, Md.)
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