Abstract: G-to-A at nt 1613 and C-to-T at nt 1653 within enhancer II and T-to-C/A at nt 1753 within core promoter were also evident: 38%, 53%, and 40%, respectively.
Nucleic acid sequence analysis of the precore region of hepatitis B virus from sera of southern African black adult carriers of the virus.
Abstract: The presence of C instead of T in position 1858 precludes the G-to-A mutation at 1896 because the coexistence of these two mutations would destabilize the stem-loop structure of the RNA encapsidation signal, a finding confirmed by our observation that the CCC polymorphism and the 1896 mutation were mutually exclusive.
Infectivity and pathogenicity in chimpanzees of a surface gene mutant of hepatitis B virus that emerged in a vaccinated infant.
PMID: 9041321
1997
The Journal of infectious diseases
Abstract: Dilutions of serum that contained the first such described HBV mutant, with an Arg-for-Gly substitution at codon 145 of the S gene, were inoculated into 6 seronegative chimpanzees.
Genotype F prevails in HBV infected patients of hispanic origin in Central America and may carry the precore stop mutant.
Abstract: Since the three published precore sequences of genotype F strains have a C1858, which is known to prevent the precore stop mutation from G to A at position 1896, the precore and part of the core genes were sequenced from 19 anti-HBe positive sera with HBV DNA, 17 with genotype F and 2 with genotype A.
Detection of hepatitis B surface gene mutation in carrier children with or without immunoprophylaxis at birth.
PMID: 9237708
1997
The Journal of infectious diseases
Abstract: A precore mutant (G to A) at nucleotide 1896 was detected in sera from 11 carriers without vaccination.
Effects of a frequent double-nucleotide basal core promoter mutation and its putative single-nucleotide precursor mutations on hepatitis B virus gene expression and replication.
PMID: 9267007
1997
The Journal of general virology
Abstract: A double mutation in the BCP which converts nucleotide (nt) 1762 from A to T and nt 1764 from G to A is frequently observed in patients with chronic hepatitis B.
Surface gene mutants of hepatitis B virus in infants who develop acute or chronic infections despite immunoprophylaxis.
Abstract: An S mutant (residue 126, Thr to Ala) initially found in an infant with fulminant hepatitis was replaced by another S mutant (residue 145, Gly to Arg) 4 days later.
Precore codon 28 stop mutation in hepatitis B virus from patients with hepatocellular carcinoma.
PMID: 9439156
1997
The Korean journal of internal medicine
Abstract: OBJECTIVES: Hepatitis B virus (HBV) with a stop mutation at precore codon 28 (TGG-->TAG, tryptophan-->stop) was investigated to clarify if such a mutant virus might play a role in hepatocarcinogenesis.
[In vitro expression of wild type and precore mutant woodchuck hepatitis virus].
PMID: 15619810
1997
Zhonghua shi yan he lin chuang bing du xue za zhi
Abstract: Hepatitis B virus (HBV) precore 1896 and 1898 G-->A mutations are regarded as hot spots to study.
A Hepatitis B Virus Variant with an Ile to Ser Mutation at aa126 of HBsAg.
PMID: 12232637
1996
Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica
Abstract: As aa126 is located in the first loop of the two-looped conformational structure of the determinant, and the Ile to Ser at aa 126 is a drastic change, it is suggested that the antigenicity of the HBsAg might be altered and the immune failure in patient No.19 was probably related to the mutation.
Abstract: There was a G at nt 531 instead of T, leading to a change of Ile to Ser at aa126 of the major HBsAg.
HBV mutation literature information.
PMID: 
1998
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