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 HBV mutation literature information.


  Naturally occurring mutations define a novel function of the hepatitis B virus core promoter in core protein expression.
 PMID: 9658127       1998       Journal of virology
Abstract: In this study, we define the molecular mechanism whereby the two core promoter mutations (C to T at nucleotide [nt] 1768 and T to A at nt 1770) result in enhanced viral encapsidation and replication.


  Recombinant HBsAg of the Wild-Type and the G145R Escape Mutant, included in the New Multivalent Vaccine against Hepatitis B Virus, Dramatically Differ in their Effects on Leukocytes from Healthy Donors In Vitro.
 PMID: 9687422       1998       Antimicrobial agents and chemotherapy
Abstract: To determine the biological relevance of the Met-to-Val substitution, we mutated a plasmid that contained a cDNA copy of the HBV pregenomic RNA such that when virus replication occurred during transient transfection of HepG2 cells, an M539V polymerase variant was produced.


  Incidence and clinical consequences of surface and polymerase gene mutations in liver transplant recipients on hepatitis B immunoglobulin.
 PMID: 9696024       1998       Hepatology (Baltimore, Md.)
Abstract: The most frequently identified amino acid substitution was glycine to arginine at position 145 (present in 4 of 6 patients who failed HBIg after at least 6 months of treatment).


  Effect of 3-beta-hydroxysteroid dehydrogenase gene deletion on virulence and immunogenicity of different vaccinia viruses and their recombinants.
 PMID: 9722876       1998       Archives of virology
Abstract: 3-beta-Hydroxysteroid dehydrogenase (3-beta-HSD) activity coded for by the A44L gene of vaccinia virus (VV) was demonstrated in CV-1 cultures infected by all five VV strains tested, viz.
Abstract: Deletion of the A44L gene in two Praha virus-derived clones (the moderately virulent P13 and the highly attenuated P20), the WR and DD viruses resulted in absence of 3-beta-HSD activity from infected cultures.
Abstract: Recombinant VVs expressing either varicella-zoster virus glycoprotein E (VZV-gE) or hepatitis B virus preS2-S protein (HBV-preS2-S) and their respective A44L deleted mutants were used in immunogenicity tests in mice.
Abstract: The virulence for mice of P13 was not affected, and that of WR was only slightly decr


  Emergence of an S gene mutant during thymosin alpha1 therapy in a patient with chronic hepatitis B.
 PMID: 9728561       1998       The Journal of infectious diseases
Abstract: Sequence analysis revealed an S gene mutant in HBsAg-seronegative serum with two consecutive amino acid substitutions: threonine115-to-isoleucine and threonine116-to-asparagine, whereas no amino acid substitution or deletion was found in the pre-S region.


  Incidence and clinical significance of hepatitis B virus precore gene translation initiation mutations in e antigen-negative patients.
 PMID: 9751010       1998       Journal of viral hepatitis
Abstract: All HBeAg-negative patients (100%) harboured the m1896 mutation and 20 (64.5%) also had a G to A mutation at nucleotide 1899 (m1899).


  Molecular analysis of the a determinant of HBsAg in children of HBeAg-positive mothers upon failure of postexposure prophylaxis.
 PMID: 9763505       1998       International journal of infectious diseases
Abstract: Only two exhibited a point mutation within the a determinant, one of which consisted of a substitution of glycine with alanine at position 145, and the other of a substitution of glutamine with arginine at position 129.


  Competition in vivo between a cytopathic variant and a wild-type duck hepatitis B virus.
 PMID: 9813205       1998       Virology
Abstract: In a mixed infection of ducklings with G133E and a small amount of wild-type virus, the wild-type virus was detected as the predominant genotype after recovery of normal liver histology.
Abstract: In vivo liver damage caused by this variant (G133E) occurred only during the first 2 weeks p.i., after which time cccDNA levels and liver histology returned to near normal despite continued virus replication.
Abstract: The results support the conclusion that the recovery from liver damage in G133E-infected ducklings was due to the emergence of spontaneous noncytopathic revertants rather than to host suppression of virus cytotoxicity.
Abstract: Two candidate revertant viral genomes were cloned directly from the serum virus of G133E-infected b


  Prevalence of mutations in core promoter/precore region in Japanese patients with chronic hepatitis B virus infection.
 PMID: 9824137       1998       Digestive diseases and sciences
Abstract: Furthermore, a mutation at nucleotide 1753 from T to C or G was frequently found in anti-HBe positive patients and was often accompanied by the double mutation.


  The sequential occurrence of viral mutations in a liver transplant recipient re-infected with hepatitis B: hepatitis B immune globulin escape, famciclovir non-response, followed by lamivudine resistance resulting in graft loss.
 PMID: 9824278       1998       Journal of hepatology
Abstract: One mutation I533L was detected during HBIg treatment.
Abstract: Three amino acid changes were selected while the patient was on lamivudine treatment, which include L533I, S559T and M550I.



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