Virusliterature

HBV mutation literature information.

Hepatitis B envelope protein mutants in human hepatocellular carcinoma tissues.

PMID: 10607231 1999 Journal of viral hepatitis

Abstract: The mutation Gly145Arg, which has been reported to be associated with immunoevasion, was found in seven of the 18 HCC tissues.

The core promoter of hepatitis B virus.

PMID: 10607259 1999 Journal of viral hepatitis

Abstract: The most frequently described mutations within this region are an A to T transversion at position 1762 together with a G to A transition at position 1764.

Polymorphism of precore region of hepatitis B virus DNA among patients with chronic HBV infection in Turkey.

PMID: 10624597 1999 Infection

Abstract: Seven of 47 HBeAg-positive patients (15%) and 29 of 34 HBeAg-negative patients (85%) had precore stop codon mutations (G to A change at nucleotide 1896).

Fulminant hepatic failure resulting from lamivudine-resistant hepatitis B virus in a renal transplant recipient: durable response after orthotopic liver transplantation on adefovir dipivoxil and hepatitis B immune globulin.

PMID: 10628774 1999 Transplantation

Abstract: Sequencing of HBV polymerase gene from preliver transplantation sera did not detect the usual lamivudine resistance mutations in the YMDD motif but instead two other mutations (F514-->L, L528-->M).

Analysis of hepatitis B virus quasispecies changes during emergence and reversion of lamivudine resistance in liver transplantation.

PMID: 10682123 1999 Antiviral therapy

Abstract: Lamivudine resistance was found to be associated with L526M and M550V changes in two patients and M550I change in three patients.

Abstract: Other changes associated with lamivudine resistance in some patients were V509I, A546V, S565A and A568T.

[Dynamic changes of basal core promoter and pre-core mutants of hepatitis B virus in patients with chronic hepatitis B virus infection].

PMID: 12759956 1999 Zhonghua shi yan he lin chuang bing du xue za zhi

Abstract: Using two mis-matched primers to amplify BCP and pre-c gene fragments, in combination with restricted fragment length polymorphism assay, we studied the presence of these two mutants(nt 1762A-->T, 1764G-->A and nt1896G-->A) in 105 serum samples.

Recombinant HBsAg of the Wild-Type and the G145R Escape Mutant, included in the New Multivalent Vaccine against Hepatitis B Virus, Dramatically Differ in their Effects on Leukocytes from Healthy Donors In Vitro.

PMID: 12759982 1999 Zhonghua shi yan he lin chuang bing du xue za zhi

Abstract: It was shown that HBV mutants with A-to-C mutation at nt585 could be confirmed.

Abstract: METHODS: A mutation specific polymerase chain reaction (msPCR) was established for amplifying HBV DNAs with A-to-C mutation at nt585.

"Identification of hepatitis B surface antigen variants with alterations outside the ""a"" determinant in immunized Singapore infants."

PMID: 9841851 1999 The Journal of infectious diseases

1Abstract: Decreased binding to ""a"" determinant-specific monoclonal antibody was observed for variants Pro120 to Ser120, Ala159 to Val159, and Phe183 to Cys183."

Abstract: These include Asn116 to Thr116, Val118 to Ala118, Pro120 to Ser120, Ala159 to Val159, Phe183 to Cys183, and Val184 to Ala184.

Abstract: Unlike other HBsAg variants, the Asn116-to-Thr116 HBsAg variant had the wild type threonine in the infant, whereas the mutated asparagine was found in the mother.

Abstract: Vertical transmission is indicated for Phe183

Transient selection of a hepatitis B virus polymerase gene mutant associated with a decreased replication capacity and famciclovir resistance.

PMID: 9862871 1999 Hepatology (Baltimore, Md.)

Abstract: The impaired replication capacity of this V542I mutant may have contributed to the absence of outgrowth of this viral strain in vivo.

Abstract: The results showed that the V542I mutant has a decreased replication capacity compared with wild type virus and does not produce HBsAg.

Abstract: The results showed the transient selection of a V542I mutant in the C domain of the viral polymerase.

Abstract: The sensitivity of the V542I mutant to penciclovir, the active metabolite of famciclovir, was further studied in tissue culture.

Mechanism of suppression of hepatitis B virus precore RNA transcription by a frequent double mutation.

PMID: 9882327 1999 Journal of virology

Abstract: A double mutation which converts nucleotide 1765 from A to T and nucleotide 1767 from G to A is frequently found in the hepatitis B virus (HBV) genome isolated from HBV patients with chronic hepatitis symptoms.

Abstract: In addition, this double mutation also resides in the X protein coding sequence, converting codon 130 from Lys to Met and codon 131 from Val to Ile.

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