Virusliterature

HBV mutation literature information.

Prevalence of naturally occurring surface gene variants of hepatitis B virus in nonimmunized surface antigen-negative Chinese carriers.

PMID: 11679975 2001 Hepatology (Baltimore, Md.)

1Abstract: These changes involved 11 positions inside and 5 outside of the historical first and second loops of the ""a"" determinant, and included the following: Q101K, T115A, K122N, T123A, T126N, Q129N, G130R, T131I, M133T, F134L, C138Y, K141E, P142S, G145R, N146S, and C147F/R."

Hepatitis B virus genomes of chronic hepatitis patients do not contain specific mutations related to acute exacerbation.

PMID: 11680583 2001 Digestive diseases and sciences

Abstract: Core promoter mutations at nucleotide positions 1762 (A to T) and 1764 (G to A) were found in both patients throughout the observation period.

Abstract: A 1896 precore stop codon mutant (G to A at nt 1896) coexisting with the wild sequence was found in both patients prior to seroconversion from HBeAg to anti-HBe.

Transcription and replication of a natural hepatitis B virus nucleocapsid promoter variant is regulated in vivo by peroxisome proliferators.

PMID: 11689047 2001 Virology

Abstract: A hepatitis B virus (HBV) transgenic mouse containing a naturally occurring mutation in the nucleocapsid promoter (A1764T plus G1766A) that inhibits the retinoid X receptor alpha (RXRalpha) plus peroxisome proliferator-activated receptor alpha (PPARalpha) heterodimer from binding to the proximal nuclear hormone receptor recognition sequence has been generated.

"Characterization of a novel hepatitis B virus mutant: demonstration of mutation-induced hepatitis B virus surface antigen group specific ""a"" determinant conformation change and its application in diagnostic assays."

PMID: 11696228 2001 Transfusion medicine (Oxford, England)

1Abstract: Interestingly, none of the mutations was found within the group-specific ""a"" determinant region (124-147) and, specifically, two of the five mutations, T118K and P120Q, were located only a few amino acids adjacent to the 124-147 region."

Prevalence of HBV core promoter/precore/core mutations in Gambian chronic carriers.

PMID: 11745929 2001 Journal of medical virology

Abstract: The two point mutations, from A to T and G to A at nt positions 1762 and 1764 in the basic core promoter region, were found in only 7/99 (7%) of the samples where this region was sequenced.

Reactivation of precore mutant hepatitis B virus in chemotherapy-treated patients.

PMID: 11753968 2001 Cancer

Abstract: A point mutation from G to A at nt 1896 was detected in five of these six patients.

Abstract: BACKGROUND: A point mutation from G to A at nucleotide (nt) 1896 of the precore region of hepatitis B virus (HBV) DNA has been shown to be associated with fulminant and severe hepatitis.

Abstract: Prophylactic use of lamivudine is strongly recommended for patients who carry mutant HBV at precore region, especially at nt 1896 (G to A), before and during chemotherapy.

Base-pair alterations in the epsilon-lower stem due to a novel double substitution in the precore gene of HBV-e negative variant were recovered by secondary mutations.

PMID: 11778699 2001 Virus genes

Abstract: In the third patient, a G1899A substitution was seen which compensated the impaired U at position 1855.

Abstract: One patient showed an additional G1897A substitution, presenting as a novel precore stop codon mutation (UGG-->UAA), followed by a compensatory mutation at position 1857.

Abstract: The HBe negative phenotype, a natural precore mutant (G1896A/G189

Abstract: The destabilized C : G base-pairing in the lower stem of epsilon-hairpin due to G1896A substitution is reportedly compensated by a second C1858T mutation and suggested to play an important role in enhanced selection of the HBe negative variant.

Comparing the immunogenicity of hepatitis B virus S gene variants by DNA immunization.

PMID: 11792065 2001 Viral immunology

Abstract: Computer modeling showed that a change from glutamine to leucine at 129 residue led to higher hydrophobicity and could result in decreased immunogenicity.

Prevalence of vaccine-induced escape mutants of hepatitis B virus in the adult population in China: a prospective study in 176 restaurant employees.

PMID: 11851835 2001 Journal of gastroenterology and hepatology

Abstract: Four out of these six cases had a point mutation within the 'a' determinant; they were Gly-145-Ala, and Ile/Thr-126-Asn/Ser.

"Effect of variation in the common ""a"" determinant on the antigenicity of hepatitis B surface antigen."

PMID: 10596008 2000 Journal of medical virology

Abstract: The results suggest that amino acid substitution of T131I, K141E and G145R and insertion of 3 amino acids between residues 123 and 124 markedly affect the antigenic structure of HBsAg.

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