Virusliterature

HBV mutation literature information.

Vaccine- and hepatitis B immune globulin-induced escape mutations of hepatitis B virus surface antigen.

PMID: 11385295 2001 Journal of biomedical science

Abstract: Notably, HBsAg with an arginine replacement for glycine at amino acid 145 is considered the quintessential immune escape mutant because it has been isolated consistently in clinical samples of HBIg-treated individuals and vaccinated infants of chronically infected mothers.

Anti-HBs after hepatitis B immunization with plasma-derived and recombinant DNA-derived vaccines: binding to mutant HBsAg.

PMID: 11395201 2001 Vaccine

1Abstract: Anti-HBs binding to synthetic peptids (25-mers, 7aa overlap) from the ""a""-loop was significantly reduced by the G145R substitution and by changing the amino acid sequence from adw(2) into adr."

Abstract: In a previous study we found that plasma-derived and recombinant DNA-derived vaccine HBsAg reacted differently with monoclonal antibodies sensitive for the G145R change.

Abstract: The G145R mutant of the small S-protein is a major escape mutant of hepatitis B virus observed in natural infection, after immunization and HBIG therapy.

Abstract: With mutant G145R rHBsAg the inhibitory activity of vaccine anti-HBs was decreased compared to

PMID: 11397661 2001 Journal of clinical virology

Abstract: Recent reports on larger series of patients pointed that other mutations residing outside of the C domain but mainly in the B domain of the viral polymerase (L528M) could be associated with these mutations in the YMDD motif.

Abstract: Sequence analysis of the reverse transcriptase domain of resistant viral strains, at the time of viral breakthrough, revealed the occurrence of mutations located in the YMDD motif within the C domain of the viral enzyme with a methionine to valine (M552V) or to isoleucine (M5521) change.

Abstract: The lamivudine resistant mutants, selected in vivo, can be classified in 2 main groups: group I with a double mutation L528M and M552V, and group II with a single mutati

Emergence of vaccine-induced escape mutant of hepatitis B virus with multiple surface gene mutations in a Korean child.

PMID: 11410701 2001 Journal of Korean medical science

1Abstract: We present for the first time in Korea the independent emergence of an escape mutant with substitution of arginine for glycine at amino acid 145 and proline for glutamate at amino acid 120 in ""a"" determinant after immunization."

Full-length genomic analysis of hepatitis B virus isolates in a patient progressing from hepatitis to hepatocellular carcinoma.

PMID: 11424118 2001 Journal of medical virology

Abstract: High frequency of mutations at nucleotides 1762(A-->T) and 1764(G-->A) in the core promoter region have been described in HCC.

Full-length genomic analysis of hepatitis B virus isolates in a patient progressing from hepatitis to hepatocellular carcinoma.

PMID: 11468748 2001 Journal of medical virology

Abstract: High frequency of mutations at nucleotides 1762(A-->T) and 1764(G-->A) in the core promoter region have been described in HCC.

Low frequency of mutations in the core promoter and precore regions of hepatitis B virus in anti-HBe positive Brazilian carriers.

PMID: 11472634 2001 BMC microbiology

Abstract: BACKGROUND: Mutations in the core promoter and precore regions of the hepatitis B virus (HBV) genome, notably the double substitution (AGG to TGA) at nt positions 1762-1764 in the core promoter, and the precore stop codon mutation G to A at nt 1896, can often explain the anti-HBe phenotype in chronic carriers.

Introduction: The most common of these mutations is a G to A substitution at nucleotide (nt) 1896, that prevents the production of HBeAg by introducing a premature stop codon into the open reading frame (ORF) of the precore region.

Introduction: The presence of a C at position 1858 precludes the

Efficacy and tolerability of long-term therapy using high lamivudine doses for the treatment of chronic hepatitis B.

PMID: 11480792 2001 Journal of gastroenterology

Abstract: The YMDD mutation was detected in 12 nonresponder patients (9 YVDD, 2 YIDD, and 1 mixed population Y(V/I)DD), generally associated with the L528M mutation.

A dominant hepatitis B virus population defective in virus secretion because of several S-gene mutations from a patient with fulminant hepatitis.

PMID: 11481624 2001 Hepatology (Baltimore, Md.)

Abstract: This was caused by a combination of amino acid changes in the S-protein including the mutation G145R frequently emerging after hyperimmunoglobulin treatment.

In vitro susceptibilities of wild-type or drug-resistant hepatitis B virus to (-)-beta-D-2,6-diaminopurine dioxolane and 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil.

PMID: 11502520 2001 Antimicrobial agents and chemotherapy

Abstract: The L526M substitution, which is associated with famciclovir resistance, conferred cross-resistance to L-FMAU but not to adefovir or DAPD.

Abstract: The M550V substitution in isolation conferred a similar phenotype to M550I, except that it did not confer significant resistance to L-FMAU.

Abstract: We found that the M550I and M550V plus L526M substitutions, which confer lamivudine resistance, did not confer cross-resistance to adefovir or DAPD, but conferred cross-resistance to L-FMAU.

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