PreS1 Mutations Alter the Large HBsAg Antigenicity of a Hepatitis B Virus Strain Isolated in Bangladesh.
PMID: 31952213
2020
International journal of molecular sciences
Discussion: Furthermore, the NTCP-binding region of preS1 showed two mutations (D27G and H39N) that require further investigations into whether these mutations affect the HBV infection efficiency.
Discussion: In addition, the D27G mutation has been identified in patients with active chronic hepatitis.
Discussion: In this study, four mutations (D27G, H39N,
Discussion: identified HBV with a C2964A mutation in the preS1 region as a novel factor associated with HCC; this mutation has also been reported in the present study.
Structural features in common of HBV and HIV-1 resistance against chirally-distinct nucleoside analogues entecavir and lamivudine.
Abstract: Additionally, we experimentally simulated previously reported ETV/3TC resistance for HBV using HIVY115F/F116Y/Q151M with F160M/M184V (L180M/M204V in HBV RT) substituted.
Introduction: 3TC is also approved as an anti-HIV-1 agent, and M184V in HIV-1 RT, which corresponds to M204V in HBV RT, has also been reported as an amino acid substitution responsible for 3TC resistance in HIV-1.
Introduction: Accordingly, we assumed that crystallographic studies of HIV-1 RT containing HBV-associated amino acids at the N-site should also provide important clues for understanding the mechanism of 3TC/ETV resistance caused by common M204V/I in HBV RT (M184V/I in HIV-1
An Association Between Core Mutations in Hepatitis B Virus Genotype F1b and Hepatocellular Carcinoma in Alaskan Native People.
Abstract: Clones containing the A2051C mutation replicated more efficiently than the wild type in association with enhanced stability of core protein dimerization.
Abstract: In the HCC patients, T1938C and A2051C mutations in the core region had accumulated significantly with A1762T/G1764A mutations in the basal core promoter (BCP) region and G1896A mutation in the precore (PC) region.
Clinical Outcome and Viral Genome Variability of Hepatitis B Virus-Induced Acute Liver Failure.
Abstract: Amino acid deletions (del; 16-22 and 20-22) in preS2 and SHB mutation L49R were exclusively detected in patients with ALF-NSR.
Effect of hepatitis B virus (HBV) surface-gene variability on markers of replication during treated human immunodeficiency virus-HBV infection in Western Africa.
Result: Three of 5 (60%) escape mutations isolated from sequences from blood donors resided within the 'a' determinant's first loop (aa 124-137), 1 (20%) within the second loop (aa 138-147), and P120L was present in the mini loop outside the range (aa 124 -147).
Result: Twelve mutations including diagnostic escape mutations (sY100C, sR122K, sT123A, sC124R, sM133T), vaccine escape mutations (sT126N, sQ129R, s
Hepatitis B e Antigen Inhibits NF-kappaB Activity by Interrupting K63-Linked Ubiquitination of NEMO.
Abstract: It is reported that the hepatitis B e antigen (HBeAg) can interfere with NF-kappaB activity, which then leads to high viral loads, while HBV with the G1896A mutation remains infectious without the production of HBeAg but can induce more severe proinflammatory response and liver damage.
Analysis of fitness differences of hepatitis B virus genotypes D and F using a cotransfection assay.
Abstract: Our results show that for the subgenotype (sgt) D1, which has an 8-nucleotide deletion (sgtD1del) and exhibits lower fitness, the levels of extracellular DNA and intracellular replicative intermediates were much lower than with sgtD1wt or sgtD1mut (G1896A), which had higher fitness.
Recombinant HBsAg of the Wild-Type and the G145R Escape Mutant, included in the New Multivalent Vaccine against Hepatitis B Virus, Dramatically Differ in their Effects on Leukocytes from Healthy Donors In Vitro.
PMID: 30472417
2019
Clinical microbiology and infection
Abstract: F30V also decreased the percentage of apoptotic cells compared with wild-type (14.8 +- 6.8% versus 19.1 +- 10.1%, p <0.01, without affecting cell-cycle progression) and increased the probability of HBx-Ser-31 being phosphorylated by PI3K-Akt kinase (known to promote anti-apoptotic activity).
Abstract: CONCLUSIONS: F30V was closely correlated with HBV-induced HCC in vivo, reduced HBV replicative efficiency by affecting HBx-binding to cccDNA and increased anti-apoptotic HBx activity in vitro.
Abstract: In vitro, F30V determined a 40% and 60% reduction in pgRNA and core-associated HBV-DNA compared with wild-type (p <0.05), in parallel with a significant decrease of
HBV mutation literature information.
PMID: 
2020
International journal of molecular sciences
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