Abstract: The rtM204I mutation associated with lamivudine resistance was identified in one infant, a second infant harboured the double A1762T/G1764A BCP mutation.
Result: Both sequences harboured the double A1762T/G1764A BCP mutation.
Result: Sequence analysis revealed the M204I mutation in the reverse transcriptase domain of the polymerase gene in the Durban sample while the Cape Town sample harboured the double A1762T/G1764A BCP mutation in the PMID: 33381105
2020
Frontiers in microbiology
Result: C1653T, T1753V and A1762T/G1764A were highly frequent in genotype G (95, 95, and 97.5%, respectively), followed by genotype C (12, 18.1, and 46.1%, respectively), while Pre-S deletions prevailed in genotype C (3.3%) (Table 1).
Result: In particular, significant differences in the frequency of G145R were observed within genotypes C and D, with the highest rates recorded for subgenotypes C6-C15 and D2 (34 and 8.2%, P < 0.001 for both; Tables 2-6).
Result: Notably, G145R was only detected in genotypes G (5.0%), D (2.5%), C (2.1%), and B (0.2%) (P < 0.001) (Table 1).
Result: Overall, rtL180M, rt PMID: 33458253
2020
Wellcome open research
Abstract: Through application of deep whole-genome sequencing we typed the isolate as genotype-D1, and identified several minority variants including G1764A and G1986A substitutions in the pre-core promoter and pre-core regions, which support CHB-AR rather than AHB.
Table: A128V
Table: A1762T
Table: C1766T/T
Table: C1799G
Table: G145R
Table: G1764A
Table: G1896A
Table: G1899A
Structural features in common of HBV and HIV-1 resistance against chirally-distinct nucleoside analogues entecavir and lamivudine.
Abstract: Additionally, we experimentally simulated previously reported ETV/3TC resistance for HBV using HIVY115F/F116Y/Q151M with F160M/M184V (L180M/M204V in HBV RT) substituted.
Introduction: 3TC is also approved as an anti-HIV-1 agent, and M184V in HIV-1 RT, which corresponds to M204V in HBV RT, has also been reported as an amino acid substitution responsible for 3TC resistance in HIV-1.
Introduction: Accordingly, we assumed that crystallographic studies of HIV-1 RT containing HBV-associated amino acids at the N-site should also provide important clues for understanding the mechanism of 3TC/ETV resistance caused by common M204V/I in HBV RT (M184V/I in HIV-1
PreS1 Mutations Alter the Large HBsAg Antigenicity of a Hepatitis B Virus Strain Isolated in Bangladesh.
PMID: 31952213
2020
International journal of molecular sciences
Discussion: Furthermore, the NTCP-binding region of preS1 showed two mutations (D27G and H39N) that require further investigations into whether these mutations affect the HBV infection efficiency.
Discussion: In addition, the D27G mutation has been identified in patients with active chronic hepatitis.
Discussion: In this study, four mutations (D27G, H39N,
Discussion: identified HBV with a C2964A mutation in the preS1 region as a novel factor associated with HCC; this mutation has also been reported in the present study.
Occurrence of occult hepatitis B virus infection associated with envelope protein mutations according to anti-HBs carriage in blood donors.
PMID: 31877352
2020
International journal of infectious diseases
Abstract: Mutations pre-s1T68I and sQ129R/L were found uniquely in 15-25% of anti-HBs(+) OBIB carriers and mutation pre-s1A54E was found preferentially in anti-HBs(+) OBIC, while 17 substitutions were found preferentially in 11-38% of anti-HBs(-) OBIB strains.
The genetic variability of hepatitis B virus subgenotype F1b precore/core gene is related to the outcome of the acute infection.
Abstract: Mutations T1753C, A1762T, G1764A, C1766T, T1768A G1896A, G2092T and T2107C were associated with acute liver failure and progression to chronic hepatitis.
Detection of circulating hepatitis B virus immune escape and polymerase mutants among HBV-positive patients attending Institut Pasteur de Bangui, Central African Republic.
PMID: 31682960
2020
International journal of infectious diseases
Abstract: Potential IEMs sY100C, sA128V, and sM133T, and several polymerase mutants were identified.
Result: Six of these (sL127I, sA128V, sG130S, sM133T, sF134I, and S140T) were located in the 'a' determinant region, among which three immune escape mutants (IEMs) (sY100C
"Characteristics of amino acid substitutions within the ""a"" determinant region of hepatitis B virus in chronically infected patients with coexisting HBsAg and anti-HBs."
PMID: 31624004
2020
Clinics and research in hepatology and gastroenterology
Abstract: The most frequent amino acid substitution was located at position s126 and the predominant substitution was sI126T in HBsAg+/anti-HBs+ patients with genotype C.
Virological Factors Associated With the Occurrence of Hepatitis B Virus (HBV) Reactivation in Patients With Resolved HBV Infection Analyzed Through Ultradeep Sequencing.
PMID: 31550370
2020
The Journal of infectious diseases
Abstract: The population of S3N amino acid substitution and nucleotide G1896A and G1899A mutations in each individual showed a similar percentage of occurrence.
Abstract: The prevalence of the S3N amino acid substitution in the envelope protein and mutations at positions G1896A and G1899A in the precore region were significantly higher in the HBVr compared with AHB.
HBV mutation literature information.
PMID: 
2020
BMC pediatrics
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