In silico functional and structural characterization of hepatitis B virus PreS/S-gene in Iranian patients infected with chronic hepatitis B virus genotype D.
1Abstract: Results: We found major hydrophilic region (MHR) mutations at ""a"" determining region that included K122R, N131T, F134Y, P142L, and T126N mutations."
Abstract: Conclusion: In the present study, mutations were identified at positions T113S and N131T within the MHR region of S protein; these mutations can potentially decrease the effect of hepatitis B vaccination in vaccine recipients.
Introduction: Also, mutations may occur in association with either vaccine-induced immune-escape (P120T, K122R, T126S, Q129H, G130N,
COLD-PCR Method for Early Detection of Antiviral Drug-Resistance Mutations in Treatment-Naive Children with Chronic Hepatitis B.
8Discussion: (2009) on 472 samples collected from treatment-naive American adults using conventional PCR combined Sanger DNA sequencing, 389 cases (82.4%) were found to not carry any NA-drug resistance mt, 79 cases (16.7%) were found with rtV207M, and only 4 cases (0.9%) were found with other ""putative"" mt."
Discussion: (2005) on the nonclassical rtV207M/I mt:the most frequent nonclassical mt found in treatment-naive patients:that rtV207M/I is regarded as a compensatory or secondary mt which led to suppression of the wt and predominance of the mt, possibly due to an increased replication competence.
Discussion: (2015) on 168 treatment-naive Chinese adults that the majority of mutants were nonclassical ones found in genotypes B and C, including
[Preparation and characterization of HBc virus like particles with site-directed coupling function].
Abstract: After expression and purification, high purity HBc(A80C) monomer protein was assembled into HBc-VLPs nanoparticles in Phosphate Buffer.
Differences in HBV Replication, APOBEC3 Family Expression, and Inflammatory Cytokine Levels Between Wild-Type HBV and Pre-core (G1896A) or Basal Core Promoter (A1762T/G1764A) Mutants.
Abstract: HBV variants, particularly the G1896A pre-core (PC) and A1762T/G1764A basal core promoter (BCP) mutations, are established risk factors for cirrhosis and HCC, but the molecular biological basis is unclear.
Abstract: RESULTS: HBeAg expression was reduced in PC and BCP variants, and higher supernatant HBV DNA and HBV RNA levels were found with A1762T/G1764A vs. G1896A mutant (p_< 0.05).
Discussion: However, these in vivo findings are in contrast with our in vitro results in which secreted HBV
The sK122R mutation of hepatitis B virus (HBV) is associated with occult HBV infection: Analysis of a large cohort of Chinese patients.
Abstract: CONCLUSIONS: The study clarified the clinical prevalence of OBI, verified the influence of immune escape-associated mutations, and identified the role of the sK122R mutation in multiple OBI patients.
Abstract: Specifically, the prevalence rates of sT118 K, sK122R, and sV168A were increased in OBI patients.
Abstract: Strains with sK122R mutants (sK122R, s
Prevalence of Potential Resistance Related Variants Among Chinese Chronic Hepatitis B Patients Not Receiving Nucleos(T)ide Analogues.
Abstract: Primary and secondary DR variants were found in 7.3% (15/206) of patients, including rtL80I/V, rtI169T, rtV173L rtL180M, rtA181T/V, rtM204I/V, and rtN236T.
Discussion: Furthermore, some variants were related to DR to entecavir and tenofovir disoproxil fumarate, such as rtI169T, rtl180M, rtM204I/
A recombinant human immunoglobulin with coherent avidity to hepatitis B virus surface antigens of various viral genotypes and clinical mutants.
Result: C149R was not detectable by any of the three antibodies, suggesting a critical role of this cysteine residue in the expression of S antigens.
Result: D144A and D144E also shared this feature.
Result: G145K and Result: Because the entire S gene is embedded within the viral polymerase gene, some viral polymerase mutations that confer drug resistance can cause amino acid sequence changes in HBsAg; major ones include E164D, W172L, L173F, I195M and W196L/S/V.
[Effect of hepatitis B virus preC/C and S gene antigen epitope mutations on HBeAg serological status in patients with chronic hepatitis B].
Abstract: After adjusting for confounding factors such as age, gender, HBV genotype, serum alanine aminotransferase level and precw28 * mutations in the longitudinal studies, the results showed that TC cell epitope (prec47-56, prec117-125, s208-216) and Th cell epitope (prec176-185) were the main independent risk factors affecting the host HBeAg serological status.
An antiviral drug-resistant mutant of hepatitis B virus with high replication capacity in association with a large in-frame deletion in the preS1 region of viral surface gene.
Abstract: In addition, all the clones harbored another nonsense mutation in the S gene (C69*) and a 207nt in-frame deletion in the preS1 region.
Abstract: Mutation(s) in the polymerase gene responsible for ADV resistance included rtA181T (all clones) and rtN236T (four clones).
Abstract: The rtA181T mutation caused the W172* nonsense mutation in the overlapping S gene.
Hepatitis B Virus preS/S Truncation Mutant rtM204I/sW196* Increases Carcinogenesis through Deregulated HIF1A, MGST2, and TGFbi.
PMID: 32887289
2020
International journal of molecular sciences
Abstract: Some of these mutants introduce premature stop codons in the overlapping surface (s) gene, including rtA181T/sW172*, which has been shown to enhance oncogenicity.
Abstract: The rtM204I/sW196* preS/S truncation may endorse the cell transformation and tumorigenesis ability via altered host gene expressions, includin
Abstract: The oncogenicity of another drug-resistant mutant, rtM204I/sW196*, has not been studied.
HBV mutation literature information.
PMID: 
2020
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