Recombinant HBsAg of the Wild-Type and the G145R Escape Mutant, included in the New Multivalent Vaccine against Hepatitis B Virus, Dramatically Differ in their Effects on Leukocytes from Healthy Donors In Vitro.
PMID: 32887289
2020
International journal of molecular sciences
Abstract: Some of these mutants introduce premature stop codons in the overlapping surface (s) gene, including rtA181T/sW172*, which has been shown to enhance oncogenicity.
Abstract: The rtM204I/sW196* preS/S truncation may endorse the cell transformation and tumorigenesis ability via altered host gene expressions, includin
Abstract: The oncogenicity of another drug-resistant mutant, rtM204I/sW196*, has not been studied.
[Clinical significance and mutation characteristics in the core promoter/pre-C region of different HBV genotypes in children].
Abstract: Further analysis showed that the age of G1721A/A1775G/T1858C containing combined mutation group was significantly lower than that of the non-mutation group [(4.58 +- 2.53) years vs.
Abstract: The mutation rates of G1721a, C1856t and T1858c of genotype C samples were 30.9%, 16.2% and 30.9%, respectively, while the mutation rates of genotype B samples were 0.4%, 0, 0, P < 0.001, respectively.
Hepatitis B virus drug resistance mutations in HIV/HBV co-infected children in Windhoek, Namibia.
Abstract: Resistance mutations included rtL80I, rtV173L, rtL180M, rtM204I/V and the overlapping sE164D, sW182*, sI195M and sW196LS variants.
Result: Additional substitutions were observed in the upper regulatory region (URR) and BCP regions: patient 2C carried the HBV URR mutant G1728A and BCP mutant PMID: 32922195
2020
International journal of medical sciences
1Abstract: By sequencing analysis, we revealed mutations at the ""a"" determinant of HBsAg, including Q129R, T131N, M133S, F134L and D144E."
1Abstract: Conclusions: Our study clarifies the prevalence of OBI in MHD patients in Sichuan Province(4.2% in the test group, 2.1% in the overall dialysis cohort), and demonstrate the mutations of Q129R and M133S in the ""a"" determinant of HBsAg for the first time."
Abstract: The Q129R and M133S mutations were first reported.
Method: The most conserved regions of S g
Investigation of immune escape-associated mutations of hepatitis B virus in patients harboring hepatitis B virus drug-resistance mutations.
PMID: 32994690
2020
World journal of gastroenterology
Abstract: HBsAg production was significantly lower and the replication capacity was significantly higher, without a significant difference in LAM/ETV susceptibility, in sA159V-containing LAM/ETV-resistant mutants than in their sA159V-lacking counterparts.
Abstract: Among these, sA159V was detected in 1.95% (136/6982) of patients with resistance mutations and 1.08% (134/12,458) of patients lacking resistance mutations (P < 0.05).
Abstract: In particular, these mutations were sQ101H/K/R, sS114A/L/T, s
Molecular and serological characterization of occult hepatitis B among blood donors in Maputo, Mozambique.
PMID: 32997000
2020
Memorias do Instituto Oswaldo Cruz
Abstract: One escape mutation (T123A) associated with OBI and various amino acid substitutions for genotype A1 and E were observed.
Result: In addition, polymorphism I195V within the S gene for all the samples was also detected in OBI individuals belonging to genotype A1 (Table II, Figs 2-3).
Result: One escape mutation (T123A) associated with OBI in one sample was observed.
Table: A159V
Table: A194V
Table: E164G
Table: F134I
Table: F220L
Table:
Quadruple mutation GCAC1809-1812TTCT acts as a biomarker in healthy European HBV carriers.
Discussion: As recently described, the BCP double mutation A1762T/G1764A is frequently (61%) found in the overall study population.
Discussion: In our study, we observed a strong association of GCAC1809-1812TTCT with BCP double mutation A1762T/G1764A in the inactive carrier group.
Discussion: In the present study, 560 patients from this cohort were analyzed for additional core mutations associated with BCP double mutation A1762T/G1764A.
Discussion: Interestingly, BCP double mutation was found in both HBeAg-positive and
Molecular epidemiology of Hepatitis B virus, Hepatitis C virus, and Hepatitis D virus in general population of Afghanistan.
PMID: 33090103
2020
The Turkish journal of gastroenterology
Abstract: C316N mutation was prevalent in 72.7% of HCV 1b participants.
Abstract: Likewise, S213T 10%, Q215P 5% and N248H 100% mutations were detected in the HBV polymerase region.
Mutational characterization of HBV reverse transcriptase gene and the genotype-phenotype correlation of antiviral resistance among Chinese chronic hepatitis B patients.
Abstract: rtL229V was the major substitution at the site of rt229.
Abstract: rtV191I and rtA181T/V were the only resistance mutations identified as genotype-specific mutation.
Abstract: A typical putative resistance mutation rtL229V was further studied using in-vitro susceptibility assays and molecular modeling.
Abstract: It contributed to the most potent suppression of viral replication and reduced the in-vitro drug susceptibility to entecavir (ETV) when coexisting with rtM204V, consistent with the hypothesis based on the molecular modeling and clinical data analysis.
Result: <
Optimization of the algorithm diagnosis chronic hepatitis B markers in patients with newly diagnosed HIV infection.
Abstract: Three HBV isolates (8.3%) were identified with drug resistance mutations to lamivudine, entericavir, telbivudine and tenofovir, which are amino acid substitutions in the HBV polymerase gene at positions L180M, T184A, M204V.
Abstract: When analyzing the basal nucleus promoter, Precore and Core regions, 22.2% of patients with the double mutation A1762T / G1764A, 25% with the mutation G1896A were identified.
HBV mutation literature information.
PMID: 
2020
International journal of molecular sciences
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