Combining the HBcrAg decline and HBV mutations predicts spontaneous HBeAg seroconversion in chronic hepatitis B patients during the immune clearance phase.
Abstract: Baseline A1574T, G1862A, G1896A, and C1913G mutations and HBcrAg levels with a sharp decrease at Week 28 were associated with spontaneous HBeAg seroconversion.
Abstract: The mutation frequencies of A1574T (51.11% vs. 18.18%, p = 0.001), G1862A (30.00% vs. 13.03%, p = 0.001), G1896A (27.22% vs. 5.45%, p = 0.001), and C1913G (32.78% vs. 12.73%, p = 0.001) in Group A were significantly higher than Group B.
Recombinant HBsAg of the Wild-Type and the G145R Escape Mutant, included in the New Multivalent Vaccine against Hepatitis B Virus, Dramatically Differ in their Effects on Leukocytes from Healthy Donors In Vitro.
Discussion: As such, a vaccine containing both wild-type and the G145R mutant HBsAg can also confer immunity to both types of the virus.
Discussion: At the same time, the inability of HBsAg with the G145R mutation to enhance the expression of CD86 on B cells may indicate a lack of a compensatory mechanism in this escape mutant.
Discussion: Comparative studies of sera from people who were vaccinated with monovalent vaccines and those recovered from HBV infection have demonstrated that only sera of the recovered patients contained highly active antibodies against both the G145R mutant HBsAg and wild-type HBsAg.
Discussion: Evaluation of cytokine production by PBMC from healthy donors in re
Identification and Characterization of Besifovir-Resistant Hepatitis B Virus Isolated from a Chronic Hepatitis B Patient.
Abstract: As a result, our study revealed that rtL180M (M) and rtM204V (V) mutations, already known as lamivudine-resistant mutations, confer resistance to BSV in the CHB patient.
Abstract: The ten mutations include rtV23I (I), rtH55R (R), rtY124H (H), rtD134E (E), rtN139K (K), rtL180M (M), rtM204V (V),
Dried blood spot sampling for hepatitis B virus quantification, sequencing and mutation detection.
Abstract: An HIV-coinfected patient presented the rtM204V/I-rtL180M double resistance mutation in serum and DBS.
Discussion: As demonstrated by Mello et al., Y100C alone may not affect HBsAg production, secretion or HBsAg affinity by commercial serological assays, as for our samples.
Discussion: In addition, L109R/V mutations were present in 2/10 samples and have been related to HBV vaccine escape and virus evasion to the host immune system.
Discussion: Overall, Y100C was the most frequent substitution, being present in 6/10 sequenced samples.
Discussion: Regarding resistance mutations, the double rt
Establishment of monoclonal antibodies broadly neutralize infection of hepatitis B virus.
Abstract: In addition, the antibodies neutralized the infection of hepatitis D virus possessing a Gly145 mutation to Arg in S protein, which is a well-known escape mutation against HBIG treatment.
Genetic diversity in enhancer II region of HBV genotype D and its association with advanced liver diseases.
Abstract: Importantly, the high frequency of some notable mutations such as E109A/Y, A110S/K, Y111D/E, and F112L was first time reported in the entire study population.
Abstract: The highest frequency of mutations S101F (62.2%), A102V/R/G/I (56.25%), M103L/A (68.75%)were found in HCC, followed in LC and CH patients as 57.1%, 42.8%, 28.52% 16%, 15.2% and 18.4% respectively.
Result: Fourteen triple nucleotide mutations were found among which the more frequent mutation in LC and PMID: 34954390
2022
Infection, genetics and evolution
Abstract: HBV polymerase rtV173L, rtL180M, and rtM204V major substitutional mutations were identified.
Analysis of entire hepatitis B virus genomes reveals reversion of mutations to wild type in natural infection, a 15 year follow-up study.
PMID: 34902556
2022
Infection, genetics and evolution
Abstract: Some sequences from subject CC246 had predicted escape substitutions (T123N, G145R) in the surface protein in 2004, 2013 and 2019 but none of the sequences from 2007 had these changes.
Novel X gene point mutations in chronic hepatitis B and HBV related cirrhotic patients.
PMID: 34920100
2022
Infection, genetics and evolution
Abstract: A higher rate of A1635T, C1678T, A1727T, A1762T, G1764A, and C1773T was observed in cirrhotic patients.
Abstract: RESULT: Novel mutations were detected, including C1491G, C1500T, G1613T, and G1658T in the N-terminal of the X gene.
Abstract: The frequency of C1481T/G1479A, T1498C, C1500T, G1512A, A1635T, PMID: 34920663
2022
Analytical chemistry
Abstract: The rtN236T mutation, an error encoded by codon 236 of the reverse transcriptase region of HBV DNA, was employed as the model gene target.
HBV mutation literature information.
PMID: 
2022
Journal of medical virology
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